Featured Publications
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans
Cortese M et al, Nature Immunology, 2025
Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Li C et al, Nat Immunology 2022
Analysis of the innate and adaptive responses to BNT162b2 in mice to show that immunization stimulated potent antibody and antigen-specific T cell responses, as well as strikingly enhanced innate responses after secondary immunization.
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Lee A et al, Nat Immunology, 2024
BCG elicits integrated organ immunity, where CD4+ T cells feed back on tissue myeloid and epithelial cells to imprint prolonged and broad innate antiviral resistance.
