Featured Publications

Systems Vaccinology

Pulendran B et al, Immunity, 2010

A review of advances, potential opportunities and challenges posed by systems biology in vaccine development.

 

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Arunachalam P et al, Nature 2021

A systems vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers who were vaccinated with the Pfizer–BioNTech mRNA vaccine (BNT162b2)

The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination

Wimmers F et al, Cell 2021

Vaccination stimulates persistent epigenomic remodeling of the innate immune system and reveal AS03’s potential as an epigentic adjuvant.

Emerging concepts in the science of vaccine adjuvants

Pulendran B et al, Nat Rev Drug Discovery, 2021

A review of the ‘known knowns’ and ‘known unknowns’ of adjuvants.

BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Lee A et al, Nat Immunology, 2024

BCG elicits integrated organ immunity, where CD4+ T cells feed back on tissue myeloid and epithelial cells to imprint prolonged and broad innate antiviral resistance.

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Li C et al, Nat Immunology 2022

Analysis of the innate and adaptive responses to BNT162b2 in mice to show that immunization stimulated potent antibody and antigen-specific T cell responses, as well as strikingly enhanced innate responses after secondary immunization.

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Arunachalam P et al, Science 2020

Analysis of immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta, Georgia, United States.