Pulendran Lab Research Highlights

Nature

Vaccination has contributed to saving more lives than any other medical intervention in history. This Milestone provides a historical perspective of the breakthroughs in the field – from the centuries-old technique of ‘variolation’ to the synthetic anti-cancer vaccines of the modern era. The Milestone includes an interactive timeline and two explanatory animations.

Vaccines work by training the immune system to target pathogens, but many types of shots need added substances called adjuvants to elicit a robust response. Despite the power of adjuvants, only one, called alum, is approved in the US. Charlotte Schubert looks at recent discoveries that could translate into a wider range of adjuvants and perhaps help provide future protection against diseases ranging from malaria to H1N1 'swine' flu.

Nature

Immunologists have raced to work out how to protect against multiple variants of SARS-CoV-2. Their research has yielded a wealth of insights and a few surprises.

expertscape

Based on 110,635 eligible articles published since 2013

Nature

Tapping into big data could inform better vaccine design.

Nature

In their Nature Immunology paper, Bali Pulendran and colleagues set out to identify innate immune signatures that could be used to predict subsequent adaptive immune responses using a combination of multi-parameter flow cytometry, multiplexed chemokine and cytokine analysis, gene expression analysis and computational modelling. 

Nature

Cutting-edge tools and analyses are digging deeper than ever before to unveil the intricacies of the diverse human immune system.