Publications – Dr. Rabinovitch

  • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011; 12(3):222-30. PMCID: PMC3079381.

  • Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M. Inhibition of Transforming Growth Factor-Beta Worsens Elastin Degradation in a Murine Model of Kawasaki Disease. Am J Pathol. 2011; 178(3):1210-20. PMCID: PMC3070551.

  • de Jesus Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M. BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol. 2011; 192(1):171-88. PMCID: PMC3019546.

  • Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinovitch M, Choi AM. Autophagic Protein LC3B Confers Resistance Against Hypoxia-Induced Pulmonary Hypertension. Am J Respir Crit Care Med. 2011; 183(5):649-58. PMCID: PMC3081281.

  • Hilgendorff A, Parai K, Ertsey R, Jain N, Navarro EF, Peterson JL, Tamosiuniene R, Nicolls MR, Starcher BC, Rabinovitch M, Bland RD. Inhibiting Lung Elastase Activity Enables Lung Growth in Mechanically Ventilated Newborn Mice. Am J Respir Crit Care Med. 2011 Sep 1;184(5):537-46PMCID: PMC3175547.

  • Alastalo T-P, Li M, de Jesus Per ez VA, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY, Rabinovitch M. Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest. 2011; 121(9):3735-46. PMCID: PMC3163943.

  • Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions. Am J Pathol. 2011 Jul 14; 179(3):1560-72. PMCID: PMC3157285.

  • Dempsie Y, Nilsen M, White K, Mair KM, Loughlin L, Ambartsumian N, Rabinovitch M, MacLean MR. Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respir Res. 2011; 12(1):159.   PMCID: PMC3276452.

  • Vanderpool RR, El-Bizri N, Rabinovitch M, Chesler NC. Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia. Biomech Model Mechanobiol. 2012; Feb 8. [Epub ahead of print].  PMID: 22314711.

  • Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn Ii GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic Plan for Lung Vascular Research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 2010;182: 1554-62. PMCID: PMC3029941

  • Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension. Circ Res. 2011; 109: 867-879.  PMCID: PMC3204361.

  • A full list of publications can be found here.

Peer Reviewed Publications Under Review/Revision:

  • Reduced BMPR-II Induces GM-CSF Translation and Macrophage Recruitment in Humans and Mice, Exacerbating Pulmonary Hypertension. Sawada H, Alastalo T-P, Glotzbach JP, Chan R, Fuchs G, Januszyk M, Lai Y-J, de Jesus Perez V, Kim Y, Wang L, Saito T, Spiekerhoetter E, Gurtner CG, Sarnow P, Rabinovitch M.
  • High Throughput Screen Identifies FK506 as an Activator of BMPR2 Signaling that Reverses Endothelial Dysfunction and Pulmonary Hypertension.  Edda Spiekerkoetter, E, Hopper RK, Li CG, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Solow-Cordero DE, El-Bizri N, ten Dijke P, Beachy PA, Rabinovitch M.
  • Loss of Adenomatous Poliposis Coli-α3 Integrin Interaction Promotes Endothelial Apoptosis in Mice and Humans.  de Jesus Perez VA, Ferreira-Tojais N, Sawada H, Wang L, Spiekerkoetter E, Dutta R, and Rabinovitch M.

Book Chapters and Invited Articles, July 2010- June 12:

  • Rabinovitch M. (2011). Pulmonary Vascular Pathophysiology. In Moller J and Hoffman J (Eds.), Pediatric Cardiovascular Medicine (pp 71-80). Oxford: Blackwell Publishing Ltd Press.
  • Rabinovitch, M. (2011). Molecular Pathogenesis of Pediatric Pulmonary Arterial Hypertension. In Beghetti, M, Barst RJ, Berger RMF, Humpl T, Ivy D, and Schulze-Neick I (Eds.) Pediatric Pulmonary Hypertension. (pp 27-46). Munich; Elsevier Press.
  • Rabinovitch M. (2011). Desarrollo normal del lecho vascular pulmonar. In Hipertensión pulmonar en niños (pp. 39-59). Diaz GF, Sandoval J and Sola A. (Eds.), Bogotá; Editorial Distribuna Press.
  • Rabinovitch M. (2011). Patogénesis molecular de hipertensión arterial pulmonar. In Hipertensión pulmonar en niños (pp. 60-83). Diaz GF, Sandoval J and Sola A. (Eds.), Bogotá; Editorial Distribuna Press.
  • Rabinovitch, M. (2011). Developmental Biology of the Pulmonary Vasculature. In Polin RA, Fox WW, and Abman SH (Eds.) Fetal and Neonatal Physiology, 4th Edition, Volume 1. (pp 757-72). Philadelphia, PA; Saunders Press.
  • Rabinovitch, M. (2011). Pulmonary Hypertension and the Extracellular Matrix (Ch 55). In Yuan JX-J, Garcia JGN, Hales CA, Rich S, Archer SL, and West JB (Eds). Textbook of Pulmonary Vascular Disease (pp 801-10).  New York, NY; Springer Press.
  • Rabinovitch M. (TBD). Chapter title. In Allen HD, Driscoll DJ, Feltes TF, and Shaddy RE (Eds),  Moss and Adams’ Heart Disease in Infants, Children, and Adolescents (?th edition) Vol ? (pp).  Philadelphia, PA: Lippincott Williams and Wilkins Press. (in press)