Bio

Honors & Awards


  • Molecular Basis of Disease Area of Focus (MBDAF) Fellow, Georgia State University (2009)
  • David W. Boykin Graduate Fellowship in Medicinal Chemistry, Georgia State University (2009)
  • Molecular Basis of Disease Area of Focus (MBDAF) Fellow, Georgia State University (2010)
  • Grad Award for Outstanding Research at the Doctoral Level and Best Overall Chem Grad Student, Georgia State University (2010)
  • University Doctoral Fellowship, Georgia State University (2011)

Professional Education


  • Doctor of Philosophy, Georgia State University (2011)
  • Master of Science, Zhejiang University (2004)
  • Bachelor of Arts and Science, Zhejiang Institute Of Technology (2001)

Stanford Advisors


Research & Scholarship

Current Research and Scholarly Interests


(1) development of new chemical probes for studying biological problems in human health and disease, (2) method for fast and specific post-synthesis modification of DNA and its further applications for, e.g. aptamer selection and array analysis (3) borononic acid-based lectin mimics (5) drug design, synthesis and biological evaluation

Publications

Journal Articles


  • Design, Synthesis, and Polymerase-Catalyzed Incorporation of Click-Modified Boronic Acid-TTP Analogues CHEMISTRY-AN ASIAN JOURNAL Cheng, Y., Dai, C., Peng, H., Zheng, S., Jin, S., Wang, B. 2011; 6 (10): 2747-2752

    Abstract

    DNA molecules are known to be important materials in sensing, aptamer selection, nanocomputing, and construction of unique architectures. The incorporation of modified nucleobases affords unique DNA properties for applications in areas that would otherwise be difficult or not possible. Earlier, we demonstrated that the boronic acid moiety can be introduced into DNA through polymerase-catalyzed reactions. In order to study whether such incorporation by polymerase is a general phenomenon, we designed and synthesized four boronic acid-modified thymidine triphosphate (TTP) analogues. The synthesis of certain analogues was through the use of a single dialkyne tether for both the Sonogashira coupling with thymidine and the later Cu-mediated [3+2] cycloaddition for linking the boronic acid moiety. This approach is much more efficient than the previously described method, and paves the way for the preparation of a large number of boronic acid-modified TTPs with a diverse set of structural features. All analogues showed very good stability under polymerase chain reaction (PCR) conditions and were recognized as a substrate by DNA polymerase, and thus incorporated into DNA.

    View details for DOI 10.1002/asia.201100229

    View details for Web of Science ID 000296273900015

    View details for PubMedID 21887745

  • Synthetic Lectin Mimics Artificial Carbohydrate Receptors" in "Carbohydrate Recognition: Biological Problems, Methods, and Applications WILEY-VCH; Ed.: Wang, B. and Boons, G-J. Yang X., Cheng Y., Wang, B. 2011: 301-327
  • Reversible Covalent Bond Toolbox" in "Supramolecular Chemistry: from Molecules to Nanomaterials by WILEY-VCH; Ed.: Gale, P. and Steed, J., Cheng Y., Peng, H., Wang, B. 2011
  • Covalent Interactions in Chemosensor Design" in "Chemosensors: Principles, Strategies, and Applications by WILEY-VCH; Ed.: Wang, B and Anslyn, E.A. Cheng Y., Yang X., Wang, B. 2011: 25-40
  • Carbohydrate Biomarkers" in "Carbohydrate Recognition: Biological Problems, Methods, and Applications by WILEY-VCH; Ed.: Wang, B. and Boons, G-J Cheng Y., Ni N., Peng, H., Jin S., Wang, B. 2011: 133-156
  • A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Peng, H., Cheng, Y., Dai, C., King, A. L., Predmore, B. L., Lefer, D. J., Wang, B. 2011; 50 (41): 9672-9675

    View details for DOI 10.1002/anie.201104236

    View details for Web of Science ID 000296205000031

    View details for PubMedID 21882324

  • Click Reactions and Boronic Acids: Applications, Issues, and Potential Solutions MOLECULES Dai, C., Cheng, Y., Cui, J., Wang, B. 2010; 15 (8): 5768-5781

    Abstract

    Boronic acids have been widely used in a wide range of organic reactions, in the preparation of sensors for carbohydrates, and as potential pharmaceutical agents. With the growing importance of click reactions, inevitably they are also applied to the synthesis of compounds containing the boronic acid moiety. However, such applications have unique problems. Chief among them is the issue of copper-mediated boronic acid degradation in copper-assisted [2,3]-cycloadditions involving an alkyne and an azido compound as the starting materials. This review summarizes recent developments, analyzes potential issues, and discusses known as well as possible solutions.

    View details for DOI 10.3390/molecules15085768

    View details for Web of Science ID 000281481100044

    View details for PubMedID 20733546

  • Carbohydrate Recognition by Boronolectins, Small Molecules, and Lectins MEDICINAL RESEARCH REVIEWS Jin, S., Cheng, Y., Reid, S., Li, M., Wang, B. 2010; 30 (2): 171-257

    Abstract

    Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of "binders" capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and "binders/receptors," and their applications. The focus is on discoveries during the last 5 years.

    View details for DOI 10.1002/med.20155

    View details for Web of Science ID 000275399200002

    View details for PubMedID 19291708

  • Synthesis and carbohydrate binding studies of fluorescent alpha-amidoboronic acids and the corresponding bisboronic acids BIOORGANIC & MEDICINAL CHEMISTRY Jin, S., Zhu, C., Cheng, Y., Li, M., Wang, B. 2010; 18 (4): 1449-1455

    Abstract

    Fluorescent boronic acids are very useful for the design and synthesis of carbohydrate sensors. In an earlier communication, we first described the effort of developing water soluble fluorescent alpha-amidoboronic acids, which change fluorescence upon sugar binding. In this report, we describe a general method of functionalizing such boronic acids and their applications in the preparation of bis-alpha-amidoboronic acids with significantly enhanced binding for oligosaccharides as compared to their monoboronic acid counterparts. The advantages of good water solubility, easy modification to generate diversity, and modularity in synthesis will make alpha-amidoboronic acids very useful building blocks for future synthesis of boronic acid-based fluorescent sensors.

    View details for DOI 10.1016/j.bmc.2010.01.017

    View details for Web of Science ID 000274425500010

    View details for PubMedID 20129789

  • Boronic Acid-Based Chemosensors" in "Artificial Receptors for Chemical Sensors by WILEY-VCH; Ed.: Mirsky, V.M. and Yatsimirsky, A.K. Yang X., Cheng Y., Jin S., Wang, B. 2010: DOI: 10.1002/9783527
  • Carbohydrate biomarkers for future disease detection and treatment Sci. China Chem. Cheng, Y., Li, MY, Wang, SR, Peng, HJ, Reid, S, Ni, NT, Fang, H, Xu, WF, Wang, BH 2010; 53 (1): 3-20
  • A New Class of Fluorescent Boronic Acids That Have Extraordinarily High Affinities for Diols in Aqueous Solution at Physiological pH CHEMISTRY-A EUROPEAN JOURNAL Cheng, Y., Ni, N., Yang, W., Wang, B. 2010; 16 (45): 13528-13538

    Abstract

    The boronic acid group is an important recognition moiety for sensor design. Herein, we report a series of isoquinolinylboronic acids that have extraordinarily high affinities for diol-containing compounds at physiological pH. In addition, 5- and 8-isoquinolinylboronic acids also showed fairly high binding affinities towards D-glucose (K(a)=42 and 46 M(-1), respectively). For the first time, weak but encouraging binding of cis-cyclohexanediol was found for these boronic acids. Such binding was coupled with significant fluorescence changes. Furthermore, 4- and 6-isoquinolinylboronic acids also showed the ability to complex methyl ?-D-glucopyranose (K(a)=3 and 2 M(-1), respectively).

    View details for DOI 10.1002/chem.201000637

    View details for Web of Science ID 000285398400031

    View details for PubMedID 20938931

  • Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing in Vibrio harveyi CHEMMEDCHEM Peng, H., Cheng, Y., Ni, N., Li, M., Choudhary, G., Chou, H. T., Lu, C., Tai, P. C., Wang, B. 2009; 4 (9): 1457-1468

    Abstract

    Bacterial quorum sensing has received much attention in recent years because of its relevance to pathological events such as biofilm formation. Based on the structures of two lead inhibitors (IC50: 35-55 microM) against autoinducer-2-mediated quorum sensing identified through virtual screening, we synthesized 39 analogues and examined their inhibitory activities. Twelve of these new analogues showed equal or better inhibitory activities than the lead inhibitors. The best compound showed an IC50 value of approximately 6 microM in a whole-cell assay using Vibrio harveyi as the model organism. The structure-activity relationship is discussed herein.

    View details for DOI 10.1002/cmdc.200900180

    View details for Web of Science ID 000270027800009

    View details for PubMedID 19533733

  • Fluoride protects boronic acids in the copper(I)-mediated click reaction CHEMICAL COMMUNICATIONS Jin, S., Choudhary, G., Cheng, Y., Dai, C., Li, M., Wang, B. 2009: 5251-5253

    Abstract

    Fluoride has been found to protect boronic acids from copper(i)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(i)-mediated click reaction.

    View details for DOI 10.1039/b909575f

    View details for Web of Science ID 000269326900010

    View details for PubMedID 19707636

  • [Synthesis and antitumor activity of arylsubstituted imidazolin-2-one derivatives]. Yao xue xue bao = Acta pharmaceutica Sinica Cheng, Y., Hu, Y., He, Q. 2005; 40 (8): 711-716

    Abstract

    To design and synthesize new arylsubstituted imidazolin-2-one analogues as antitumor compounds.Arylsubstituted imidazolin-2-ones were prepared by condensation the appropriate omega-amino-acetophenone hydrochloride with arylisocyanate in toluene. The target compounds prepared in this study were tested for cytotoxicity against PC-3, A549, HO-8910, Hela, HL60, K562 and HL60R cancer cell lines, and mechanism of one of the products 4y was further evaluated with its mechanium.Thirty-six new compounds were synthesized and confirmed by 1H NMR, MS and elemental analysis. One of the synthesized products, compound 4y, displayed an encouraging selective activity against HL60 cells, and it was partlydue to the cell cycle arrest and cell apoptosis.Compound 4y is worthy to be intensively studied.

    View details for PubMedID 16268505

  • Synthesis of Arylsubstituted Imidazolin-2-one Analogues Chinese Chem. Lett. Cheng Y., Hu Y. 2004; 15 (11): 1281-1284

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