Ved Topkar

MD Student, expected graduation Spring 2024 Ph.D. Student in Biophysics, admitted Autumn 2018 MSTP Student

Bio

I am a lover of all things RNA currently interested in studying sub-cellular localization of mRNA molecules. Using primary oligodendrocytes as a model system, I am studying the mechanisms of mRNA transport in myelin development.

All Publications

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Research Interests
Our lab are developing gene-editing technologies, such as CRISPR systems for in vivo therapy, and cleavage-free techniques for large gene insertion via microbial recombinase. Our team also pioneers in single-cell tracking for cancer and immunology studies using novel CRISPR tools. To accelerate our work, we integrate AI and machine learning into these technologies, design and evolve proteins/RNAs, pushing frontiers in understanding and treating neurological and immunological disease.

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Rhiju Das

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Research Interests
Our lab seeks an agile and predictive understanding of how nucleic acids and proteins code for information processing in living systems. We develop new computational & chemical tools to enable the precise modeling, regulation, and design of RNA and RNA/protein machines.

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Elizabeth Egan

Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Clinical Focus
Pediatric Infectious Diseases
Research Interests
Malaria is a parasitic disease transmitted by mosquitos that is a leading cause of childhood mortality globally. Public health efforts to control malaria have historically been hampered by the rapid development of drug resistance. The goal of our research is to understand the molecular determinants of critical host-pathogen interactions in malaria, with a focus on the erythrocyte host cell. Our long-term goal is to develop novel approaches to prevent or treat malaria and improve child health.

36 Total Publications
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Jesse Engreitz

Assistant Professor of Genetics
Research Interests
Regulatory elements in the human genome harbor thousands of genetic risk variants for common diseases and could reveal targets for therapeutics — if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body.

We combine experimental and computational genomics, biochemistry, molecular biology, and genetics to assemble regulatory maps of the human genome and uncover biological mechanisms of disease.

62 Total Publications
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Richard Frock

Assistant Professor of Radiation Oncology (Radiation and Cancer Biology)
Research Interests
We are a functional genomics laboratory interested in elucidating mechanisms of DNA repair pathway choice and genome instability. We employ a powerful discovery platform, High-Throughput Genome-wide Translocation Sequencing (HTGTS), which maps DNA junctions at single nucleotide resolution. Our expertise overlaps many different fields including: genome editing, ionizing radiation and cancer therapeutics, V(D)J and IgH class switch recombination, and meiosis.

29 Total Publications
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Alex Gao

Assistant Professor of Biochemistry
Research Interests
Nature has created many powerful biomolecules that are hidden in organisms across kingdoms of life. Many of these biomolecules originate from microbes, which contain the most diverse gene pool among living organisms. We are integrating high-throughput computational and experimental approaches to harness the vast diversity of genes in microbes to develop new antibiotics and molecular biotechnology, and to investigate the evolution of proteins and molecular mechanisms in innate immunity.

15 Total Publications
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William Greenleaf

Professor of Genetics
Research Interests
Our lab focuses on developing methods to probe both the structure and function of molecules encoded by the genome, as well as the physical compaction and folding of the genome itself. Our efforts are split between building new tools to leverage the power of high-throughput sequencing technologies and cutting-edge optical microscopies, and bringing these technologies to bear against basic biological questions by linking DNA sequence, structure, and function.

174 Total Publications
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Pehr Harbury

Associate Professor of Biochemistry
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Scientific breakthroughs often come on the heels of technological advances; advances that expose hidden truths of nature, and provide tools for engineering the world around us. Examples include the telescope (heliocentrism), the Michelson interferometer (relativity) and recombinant DNA (molecular evolution). Our lab explores innovative experimental approaches to problems in molecular biochemistry, focusing on technologies with the potential for broad impact.

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Daniel Herschlag

Professor of Biochemistry and, by courtesy, of Chemical Engineering
Research Interests
Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

335 Total Publications
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Hanlee P. Ji

Professor of Medicine (Oncology) and, by courtesy of Electrical Engineering
Clinical Focus
Cancer > GI Oncology, Medical Oncology, Oncology (Cancer), Gastrointestinal Neoplasms, Inherited Cancer Disorders, Immunotherapy in gastrointestinal cancers
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Cancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis

198 Total Publications