Timothy Doyle

Associate Director for Neuroscience Community Labs, Wu Tsai Neurosciences Institute

All Publications

Publications (31)

All Publications (31)
Journal Articles (29)
Books and Book Chapters (1)
Conference Proceedings (1)

Profiles With Related Publications

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Sandip Biswal, MD

Adjunct Clinical Professor, Radiology
Clinical Focus
Diagnostic Radiology, Radiology, Musculoskeletal Imaging, Musculoskeletal Interventional Procedures, Clinical Trials, Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI), Pain Imaging Diagnostics
Research Interests
The management of individuals suffering from chronic pain is unfortunately limited by poor diagnostic tests and therapies. Our research group is interested in 'imaging pain' by using novel imaging techniques to study peripheral nociception and inflammation with the goal of accurately identifying the location of pain generators. We are developing new approaches with positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET/MRI) and are currently in clinical trials.

89 Total Publications
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Helen M. Blau

Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology and Professor, by courtesy, of Psychiatry and Behavioral Sciences
Research Interests
Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.

294 Total Publications
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Patrick O. Brown

Professor of Biochemistry, Emeritus
Research Interests
Dr. Brown, currently an emeritus professor, is CEO and founder of Impossible Foods, a company dedicated to replacing the world's most destructive technology - the use of animals to transform plant biomass into meat, fish and dairy foods - by developing a new and better way to produce the world's most delicious, nutritious and affordable meats, fish and dairy foods directly from plants. Visit impossiblefoods.com for more information.

319 Total Publications
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Michele Calos

Professor of Genetics, Emerita
Research Interests
My lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.

We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.

We are working on 3 forms of muscular dystrophy.

We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.

134 Total Publications
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Ian Y Chen, MD, PhD

Assistant Professor of Medicine (Cardiovascular) and of Radiology (Veterans Affairs)

57 Total Publications
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Christopher H. Contag

Professor of Pediatrics (Neonatology), Emeritus
Research Interests
We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

347 Total Publications
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Martha S. Cyert

Dr. Nancy Chang Professor
Research Interests
The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.

67 Total Publications
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Amato J. Giaccia

Jack, Lulu and Sam Willson Professor, Professor of Radiation Oncology, Emeritus
Research Interests
During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.

403 Total Publications
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Anna Hnatiuk Hnatiuk

Postdoctoral Scholar, Cardiovascular Institute

13 Total Publications
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Ngan F. Huang

Associate Professor of Cardiothoracic Surgery (Cardiothoracic Surgery Research) and, by courtesy, of Chemical Engineering
Research Interests
Dr. Huang's laboratory aims to understand the chemical and mechanical interactions between extracellular matrix (ECM) proteins and pluripotent stem cells that regulate vascular and myogenic differentiation. The fundamental insights of cell-matrix interactions are applied towards stem cell-based therapies with respect to improving cell survival and regenerative capacity, as well as engineered vascularized tissues for therapeutic transplantation.

103 Total Publications
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Mark A. Kay, M.D., Ph.D.

Dennis Farrey Family Professor of Pediatrics, and Professor of Genetics
Research Interests
Mark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.

439 Total Publications
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Paul A. Khavari, MD, PhD

Carl J. Herzog Professor of Dermatology in the School of Medicine
Clinical Focus
Cancer > Cutaneous (Dermatologic) Oncology, Dermatology, General Dermatology
Research Interests
We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.

217 Total Publications