Bio

Honors & Awards


  • Graduate Research Fellowship Program, National Science Foundation (June 2017 - June 2020)
  • Stanford Graduate Fellowships in Science and Engineering (SGF), Stanford (August 2015 - August 2018)

Education & Certifications


  • B.S., New York University, Neural Science (2015)

Publications

All Publications


  • The Zika threat to the periphery. Nature neuroscience Khan, T. A., Paşca, S. P. 2017; 20 (9): 1191–92

    View details for PubMedID 28849792

  • Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron Sloan, S. A., Darmanis, S., Huber, N., Khan, T. A., Birey, F., Caneda, C., Reimer, R., Quake, S. R., Barres, B. A., Paşca, S. P. 2017; 95 (4): 779–90.e6

    Abstract

    There is significant need to develop physiologically relevant models for investigating human astrocytes in health and disease. Here, we present an approach for generating astrocyte lineage cells in a three-dimensional (3D) cytoarchitecture using human cerebral cortical spheroids (hCSs) derived from pluripotent stem cells. We acutely purified astrocyte-lineage cells from hCSs at varying stages up to 20 months in vitro using immunopanning and cell sorting and performed high-depth bulk and single-cell RNA sequencing to directly compare them to purified primary human brain cells. We found that hCS-derived glia closely resemble primary human fetal astrocytes and that, over time in vitro, they transition from a predominantly fetal to an increasingly mature astrocyte state. Transcriptional changes in astrocytes are accompanied by alterations in phagocytic capacity and effects on neuronal calcium signaling. These findings suggest that hCS-derived astrocytes closely resemble primary human astrocytes and can be used for studying development and modeling disease.

    View details for PubMedID 28817799