Bio

Professional Education


  • Doctor of Philosophy, University of Washington (2011)

Stanford Advisors


Publications

Journal Articles


  • Revisiting caspase-11 function in host defense. Cell host & microbe Ng, T. M., Monack, D. M. 2013; 14 (1): 9-14

    Abstract

    Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease.

    View details for DOI 10.1016/j.chom.2013.06.009

    View details for PubMedID 23870309

  • Policing the cytosol-bacterial-sensing inflammasome receptors and pathways CURRENT OPINION IN IMMUNOLOGY Ng, T. M., Kortmann, J., Monack, D. M. 2013; 25 (1): 34-39

    Abstract

    Pattern recognition receptors recognize signals originating from pathogens and comprise a large part of the arsenal in innate immune responses. The NOD-like receptors (NLRs) are one particular class of these receptors that survey the cytoplasm for signs of pathogen invasion. Upon detection, they trigger the formation of a macromolecular complex called the inflammasome that is required for elimination of the pathogen, as well as amplifying a pro-inflammatory response. Although the core machinery has been defined, recent data emphasize the complexity of how NLR inflammasomes function. Here, we highlight new discoveries that reveal how precisely fine-tuned NLR inflammasome functions are, and how that may be modulated by antagonistic effects of concomitant inflammasome activation as well as novel regulatory factors.

    View details for DOI 10.1016/j.coi.2012.11.009

    View details for Web of Science ID 000316777300005

    View details for PubMedID 23261344

Stanford Medicine Resources: