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Principal Investigator, PharmGKB<br/>Principal Investigator, CPIC<br/>Principal Investigator, PharmCAT<br/>Principal Investigator, ClinGen
My research interests extend over the broad spectrum of pharmacogenomics, personalized medicine, computational biology and bioinformatics. Applications include the development of a pharmcogenomics knowledge base, clinical dosing guidelines for pharmacogenomics, annotation of human genome, de novo modeling and the structural basis of disease.<br/><br/> My current research areas involve the studies of the following:<br/><br/> * development of an integrated knowledge base about how variation in human genetics leads to variation in our response to drugs<br/> * the stability of the collagen triple helix<br/> * the relationship and prediction of lethal mutations for the genetic collagenous disease Osteogenesis imperfecta