Bio

Education & Certifications


  • BS, University of California, Irvine, Biological Sciences (2016)

Publications

All Publications


  • Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation. Neurobiology of Disease Xie, Y., Ng, N. N., Safrina, O. S., Ramos, C. M., Ess, K. C., Schwartz, P. H., Smith, M. A., O'Dowd, D. K. 2020

    View details for DOI 10.1101/524835

  • Emerging role of stem cell-derived extravesicular microRNAs in age-associated human diseases and in different therapies of longevity. Ageing Research Reviews Ullah, M., Ng, N. N., Concepcion, W., Thakor, A. S. 2020
  • Mesenchymal stem cells confer chemoresistance in breast cancer via a CD9 dependent mechanism. Oncotarget Ullah, M. n., Akbar, A. n., Ng, N. N., Concepcion, W. n., Thakor, A. S. 2019; 10 (37): 3435?50

    Abstract

    The development of chemotherapy drug resistance remains a significant barrier for effective therapy in several cancers including breast cancer. Bone marrow-derived mesenchymal stem cells (BMMSCs) have previously been shown to influence tumor progression and the development of chemoresistance. In the present study, we showed that when GFP labelled BMMSCs and RFP labelled HCC1806 cells are injected together in vivo, they create tumors which contain a new hybrid cell that has characteristics of both BMMSCs and HCC1806 cells. By labelling these cells prior to their injection, we were then able to isolate new hybrid cell from harvested tumors using FACS (DP-HCC1806:BMMSCs). Interestingly, when DP-HCC1806:BMMSCs were then injected into the mammary fat pad of NOD/SCID mice, they produced xenograft tumors which were smaller in size, and exhibited resistance to chemotherapy drugs (i.e. doxorubicin and 5-fluorouracil), when compared tumors from HCC1806 cells alone. This chemoresistance was shown to associated with an increased expression of tetraspanins (CD9, CD81) and drug resistance proteins (BCRP, MDR1). Subsequent siRNA-mediated knockdown of BMMSC-CD9 in DP-HCC1806:BMMSCs resulted in an attenuation of doxorubicin and 5-fluorouracil chemoresistance associated with decreased BCRP and serum cytokine expression (CCL5, CCR5, CXCR12). Our findings suggest that within the tumor microenvironment, CD9 is responsible for the crosstalk between BMMSCs and HCC1806 breast cancer cells (via CCL5, CCR5, and CXCR12) which contributes to chemoresistance. Hence, BMMSC-CD9 may serve as an important therapeutic target for the treatment of breast cancer.

    View details for DOI 10.18632/oncotarget.26952

    View details for PubMedID 31191817

    View details for PubMedCentralID PMC6544397

  • Reproducible and efficient generation of functionally active neurons from human iPSCs for preclinical disease modeling. Stem Cell Research *Xie, Y., *Schutte, R. J., *Ng, N. N., Ess, K. C., Schwartz, P. H., O'Dowd, D. K. 2018; 26: 84-94 (*authors contributed equally)
  • Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons. Journal of Neuroscience Methods *Schutte, R. J., *Xie, Y., *Ng, N. N., Figueroa, P., Pham, A. T., O'Dowd, D. K. 2018; 294: 91-101 (*authors contributed equally)
  • Research Associates Program: Expanding clinical research productivity with undergraduate students. SAGE Open Medicine Hoonpongsimanont, W., Sahota, P. K., Ng, N. N., Farooqui, M. J., Chakravarthy, B., Patel, B., Lotfipour, S. 2017; 5: 1-7

    View details for DOI 10.1177/2050312117730245

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