Manifestations and mechanisms of stem cell aging
JOURNAL OF CELL BIOLOGY
2011; 193 (2): 257-266
Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair. In most tissues, there is an age-related decline in stem cell functionality but not a depletion of stem cells. Such functional changes reflect deleterious effects of age on the genome, epigenome, and proteome, some of which arise cell autonomously and others of which are imposed by an age-related change in the local milieu or systemic environment. Notably, some of the changes, particularly epigenomic and proteomic, are potentially reversible, and both environmental and genetic interventions can result in the rejuvenation of aged stem cells. Such findings have profound implications for the stem cell-based therapy of age-related diseases.
View details for DOI 10.1083/jcb.201010131
View details for Web of Science ID 000289673000003
View details for PubMedID 21502357
View details for PubMedCentralID PMC3080271