School of Medicine
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Paul George, MD, PhD
Assistant Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests CONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes.
Clinical Assistant Professor, Neurology & Neurological Sciences
Bio Dr. Gold is a board-certified general neurologist who is fellowship-trained in the diagnosis and treatment of neurological disorders in hospitalized patients. He cares for a broad range of patients, including individuals with seizures, central nervous system infections, autoimmune diseases, headaches, neuromuscular conditions, and neurological complications of cancer. Dr. Gold has a particular clinical interest in the inpatient diagnosis of uncommon or rare neurological disorders. He directs quality improvement for the department of Neurology and is actively involved in projects to improve the experience of hospitalized patients with neurological conditions at Stanford. His primary research interest focuses on enhancing the communication skills of neurology residents and he serves as the Director of the Stanford Neurology Residency Communication Coaching Program. He is also the Fellowship Director of the Stanford Neurohospitalist Fellowship.
For more information on the Stanford Neurohospitalist Program & Fellowship, please visit: https://med.stanford.edu/neurology/divisions/neurohospitalist.html
Additional information on Stanford Neurology's efforts in Quality, Safety, & Value can be found here: http://med.stanford.edu/neurology/quality.html
Neelam Goyal, MD
Clinical Associate Professor, Neurology & Neurological Sciences
Current Research and Scholarly Interests Dr. Goyal specializes in the diagnosis, management, and electrophysiological testing of neuromuscular diseases. Through collaboration with a multidisciplinary team including therapists, research scientists, and ancillary staff, her work focuses on providing state of the art, comprehensive care to patients living with neuromuscular diseases. Her clinical research interests include ALS and sleep, hereditary neuropathies, and neuromuscular junction disorders.
Gerald Grant, MD, FACS
Endowed Professor in Pediatric Neurosurgery and Professor, by courtesy, of Neurology at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Grant directs a Blood-brain Barrier Translational Laboratory focusing on enhancing drug delivery to brain tumors in children.
Michael Greicius, MD, MPH
Associate Professor of Neurology and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests As the Medical Director of the Stanford Center for Memory Disorders and Principal Investigator of the Stanford Extreme Phenotypes in Alzheimer's Disease (StEP AD) Cohort, Dr. Greicius' research focuses on elucidating the neurobiologic underpinnings of AD. His lab combines cutting edge brain imaging, "deep" phenotyping, and whole-genome sequencing of human subjects to identify novel pathways involved in AD pathogenesis. The goal of his work is to develop effective treatment for AD patients.