Bio

Clinical Focus


  • Anesthesia

Academic Appointments


Professional Education


  • Board Certification: American Board of Anesthesiology, Anesthesia (2020)
  • Fellowship: Stanford University Pediatric Anesthesia Fellowship (2020) CA
  • Board Certification: American Board of Pediatrics, Pediatrics (2019)
  • Residency: Stanford University Pediatric and Anesthesiology Residency (2019) CA
  • Medical Education: Dartmouth Geisel School of Medicine Office of the Registrar (2014) NH

Publications

All Publications


  • Moyamoya disease in children and its anesthetic implications: A review PEDIATRIC ANESTHESIA Giustini, A. J., Stone, S. A., Ramamoorthy, C. 2020

    View details for DOI 10.1111/pan.14001

    View details for Web of Science ID 000568620600001

  • Association Between Citations, Altmetrics, and Article Views in Pediatric Research. JAMA network open Giustini, A. J., Axelrod, D. M., Lucas, B. P., Schroeder, A. R. 2020; 3 (7): e2010784

    View details for DOI 10.1001/jamanetworkopen.2020.10784

    View details for PubMedID 32687584

  • The effect of hypofractionated radiation and magnetic nanoparticle hyperthermia on tumor immunogenicity and overall treatment response Hoopes, P., Wagner, R. J., Song, A., Osterberg, B., Gladstone, D. J., Bursey, A. A., Fiering, S. N., Giustini, A. J., Ryan, T. P. SPIE-INT SOC OPTICAL ENGINEERING. 2017

    Abstract

    It is now known that many tumors develop molecular signals (immune checkpoint modulators) that inhibit an effective tumor immune response. New information also suggest that even well-known cancer treatment modalities such as radiation and hyperthermia generate potentially beneficial immune responses that have been blocked or mitigated by such immune checkpoints, or similar molecules. The cancer therapy challenge is to; a) identify these treatment-based immune signals (proteins, antigens, etc.); b) the treatment doses or regimens that produce them; and c) the mechanisms that block or have the potential to promote them. The goal of this preliminary study, using the B6 mouse - B16 tumor model, clinically relevant radiation doses and fractionation schemes (including those used clinically in hypofractionated radiation therapy), magnetic nanoparticle hyperthermia (mNPH) and sophisticated protein, immune and tumor growth analysis techniques and modulators, is to determine the effect of specific radiation or hyperthermia alone and combined on overall treatment efficacy and immunologic response mechanisms. Preliminary analysis suggests that radiation dose (10 Gy vs. 2 Gy) significantly alters the mechanism of cell death (apoptosis vs. mitosis vs. necrosis) and the resulting immunogenicity. Our hypothesis and data suggest this difference is protein/antigen and immune recognition-based. Similarly, our evidence suggest that radiation doses larger than the conventional 2 Gy dose and specific hyperthermia doses and techniques (including mNP hyperthermia treatment) can be immunologically different, and potentially superior to, the radiation and heat therapy regimens that are typically used in research and clinical practice.

    View details for PubMedID 29515284

  • Pediatric Postoperative Pulse Oximetry Monitoring During Transport to the Postanesthesia Care Unit Reduces Frequency of Hypoxemia. Joint Commission journal on quality and patient safety Caruso, T. J., Mokhtari, T. E., Coughlan, M. J., Wu, D. S., Marquez, J. L., Duan, M., Freeman, H., Giustini, A., Tweedy, M., Sharek, P. J. 2017; 43 (3): 146?50

    Abstract

    The standard use of pulse oximetry during the transport of postoperative patients from the operating room (OR) to the postanesthesia care unit (PACU) is not routinely practiced. A study was conducted to determine if the frequency of hypoxemia on admission to the PACU decreased after implementation of routine use of transport pulse oximeters for postoperative patients being transferred to the PACU.In this prospective cohort study, which was conducted at an academic pediatric hospital, the primary outcome measure was the frequency of hypoxemic events on arrival to the PACU.A total of 506 patients in the preintervention phase and 597 in the postintervention phase met the inclusion criteria. Six hypoxemic events on arrival to the PACU were identified in preintervention phase versus zero in the postintervention period, p?=?0.009. Use of oxygen monitors during transport from the OR to the PACU increased from 0% to 100%, p?

    View details for DOI 10.1016/j.jcjq.2016.12.001

    View details for PubMedID 28334593

Footer Links:

Stanford Medicine Resources: