Bio
My professional interests are the clinical pharmacology of intravenous anesthetic drugs. This has led me to clinical studies of many of the intravenous opioids and hypnotics used in anesthetic practice. However, my passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to "in silico" pharmacogenetics.
Clinical Focus
- Anesthesia
- Regional Anesthesia
- Total Intravenous Anesthesia
Honors & Awards
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Fellowship by Election, The Royal College of Anaesthetists (2003)
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Bernard H. Eliasberg Medal, Mt. Sinai Medical Center, New York, NY (2006)
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Ellis Gillespie Lecture, Australian and New Zealand College fo Anaesthetists (2008)
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Rank Visiting Lecturer, Royal College of Anaesthetists (2008)
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Virginia Apgar Lecture, Department of Anesthesiology, Columbia University (2008)
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FAER Honorary Research Lecture, American Society of Anesthesiologists (2008)
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Corresponding Member, German Society of Anaesthesiology and Intensive Care Medicine (2009)
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Stephen J. Prevoznik Lecture, Department of Anesthesiology, University of Pennsylvania (2009)
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Ralph Waters Visiting Professor, Department of Anesthesiology, University of Wisconsin (2009)
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Leon Goldberg Lecture, University of Chicago (2010)
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Lifetime Achievement Award, International Society of Anaesthetic Pharmacology (2011)
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Terry Davidson Plenary Lecture, Israel Society of Anesthesiologists (2011)
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Honorary Fellow, College of Anaesthetists of Ireland (2012)
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Sir Ivan Magill Inaugural Lecture, College of Anaesthetists of Ireland (2012)
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Honorary Member, German Society of Anaesthesiology and Intensive Care Medicine (2013)
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David M. Little Prize, Anesthesia History Association (2013)
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Gold Medal, Royal College of Anaesthetists (2013)
Boards, Advisory Committees, Professional Organizations
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Chair, Anesthesia Advisory Panel on Sedasys, Ethicon Endo-Surgery (2003 - 2007)
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Editor-in-Chief, Anesthesia and Analgesia (2006 - 2016)
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Member, Committee on Drug Disposition, American Society of Anesthesiologists (1992 - 1999)
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Chair, Committee on Drug Disposition, American Society of Anesthesiologists (2000 - 2005)
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Member, NIGMS Pharmacological Sciences Review Committee (1993 - 1997)
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Member, Department of Veterans Affairs Merit Review Committee for Alcoholism and Drug Dependence (1995 - 1999)
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Member, FDA Anesthetic and Life Support Drugs Advisory Committee (2002 - 2004)
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Chair, FDA Anesthetic and Life Support Drugs Advisory Committee (2004 - 2006)
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Member, Academy of Anesthesia Mentors (2004 - Present)
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Expert Reviewer, California Medical Board (2012 - Present)
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Editor, Clinical Pharmacokinetics (1996 - 1997)
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Associate Editor, Anesthesiology (1998 - 1999)
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Editor, Anesthesiology (2003 - 2005)
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Associate Editor, Clinical Pharmacology and Therapeutics (1998 - 2008)
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Associate Editor, Journal of Pharmacokinetics and Biopharmaceutics (2000 - 2006)
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Incoming EIC, Anesthesia and Analgesia (2005 - 2006)
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Member, International Editorial Board, British Journal of Anaesthesia (2006 - Present)
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Member, Advisory Board, Journal of Anesthesia (2009 - Present)
Professional Education
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Fellowship:Stanford University School of Medicine Registrar (1987) CA
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Residency:Hospital of the University of Pennsylvania (1986) PA
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Medical Education:Stanford University School of Medicine (1983) CA
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Board Certification: Anesthesia, American Board of Anesthesiology (1987)
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Internship:Hospital of the University of Pennsylvania (1984) PA
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Post-Doctoral, Stanford University, Clinical Pharmacology (1987)
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Residency, University of Pennsylvania, Anesthesiology (1986)
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MD, Stanford University, Medicine (1983)
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AB, Princeton University, Biology (1978)