Bio

Honors & Awards


  • National Research Service Award (NRSA), National Institutes of Health (NIH) (2013-2016)
  • Regina Casper Stanford Graduate Fellowship, Stanford University (2009-2013)

Research & Scholarship

Lab Affiliations


Publications

Journal Articles


  • Human LilrB2 is a ß-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science Kim, T., Vidal, G. S., Djurisic, M., William, C. M., Birnbaum, M. E., Garcia, K. C., Hyman, B. T., Shatz, C. J. 2013; 341 (6152): 1399-1404

    Abstract

    Soluble ?-amyloid (A?) oligomers impair synaptic plasticity and cause synaptic loss associated with Alzheimer's disease (AD). We report that murine PirB (paired immunoglobulin-like receptor B) and its human ortholog LilrB2 (leukocyte immunoglobulin-like receptor B2), present in human brain, are receptors for A? oligomers, with nanomolar affinity. The first two extracellular immunoglobulin (Ig) domains of PirB and LilrB2 mediate this interaction, leading to enhanced cofilin signaling, also seen in human AD brains. In mice, the deleterious effect of A? oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of AD, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cortex. These findings imply that LilrB2 contributes to human AD neuropathology and suggest therapeutic uses of blocking LilrB2 function.

    View details for DOI 10.1126/science.1242077

    View details for PubMedID 24052308

  • NKCC1 cotransporters: keeping an 'ion' them. journal of physiology Vidal Pérez-Treviño, G. S. 2011; 589: 781-782

    View details for DOI 10.1113/jphysiol.2010.203919

    View details for PubMedID 21486847

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