Sophia Chernikova

Sr Res Scientist-Basic Ls, Neurosurgery

Projects

• Role of microtubule-dependent cell trafficking in DNA repair and chemotherapy response of estrogen-negative breast cancer

Location

Stanford University
• Testing the efficacy of inhibitors of stromal derived factor 1 (SDF-1) pathway in post-irradiation treatment of breast cancer brain metastases

Location

Stanford University
• Role of SDF-1 mediated pathway in glioblastoma recurrence after whole-brain irradiation, Stanford University

Location

Stanford University
• Role of chromatin remodeling in radiation response and genomic instability

Location

Stanford University
• Development of a compound library screen aimed at finding small-molecule inhibitors of homologous recombination

Location

Stanford University
• Investigating mechanisms of action of hypoxia-activated cytotoxins, including the dinitrobenzamide mustard PR104A and tirapazamine

Identified homologous recombination pathway as a main pathway for repair of damage induced by a tirapazamine.

Location

Stanford University

Education & Certifications

MS, Engineer-Physicist, Moscow Institute of Physics and Technology, Applied Math and Physics (1990)
PhD, Colorado State University, Cell and Molecular Radiation Biology (1998)

All Publications

Profiles With Related Publications

close
Martin Brown

Professor of Radiation Oncology, Emeritus
Research Interests
We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy.

362 Total Publications
close
Gilbert Chu

Professor of Medicine (Oncology) and of Biochemistry
Research Interests
After shuttering the wet lab, we have focused on: a point-of-care device to measure blood ammonia and prevent brain damage; a human protein complex that juxtaposes and joins DNA ends for repair and V(D)J recombination; and strategies for teaching students and for reducing selection bias in educational programs.

74 Total Publications
close
Karlene Cimprich

Professor of Chemical and Systems Biology and, by courtesy, of Biochemistry
Research Interests
Genomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.

75 Total Publications
close
Gerald Crabtree

David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Research Interests
Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin and epigenetic regulation in living cells.

262 Total Publications
close
Magdalena Crossley

Instructor, Chemical and Systems Biology

15 Total Publications
close
Theresa Endres

Postdoctoral Scholar, Chemical and Systems Biology

5 Total Publications
close
Dean W. Felsher

Professor of Medicine (Oncology) and of Pathology
Research Interests
My laboratory studies the molecular basis of cancer with a focus on understanding when cancer can be reversed through targeted oncogene inactivation.

217 Total Publications
close
Or Gozani

Dr. Morris Herzstein Professor
Research Interests
We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.

122 Total Publications
close
Yuchao Gu

Instructor, Stanford Cancer Institute

7 Total Publications
close
Philip C. Hanawalt

Dr. Morris Herzstein Professor in Biology, Emeritus
Research Interests
My current interest includes two principal areas:

1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review.

2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.

241 Total Publications
close
Peter K. Jackson

Professor of Microbiology and Immunology (Baxter Labs) and of Pathology
Research Interests
Cell cycle and cyclin control of DNA replication .

180 Total Publications
close
Mohammed Imran Khan

Postdoc Res Affiliate, OHNS/Laryngology Division Visiting Instructor, OHNS/Laryngology Division