Bio

Bio


I am a biomedical engineer specifically interested in finding diagnostic capabilities that advance medicine at the interface of engineering and the clinical/biological sciences. I am researching MR physics and engineering development for PET/MR and Ultra High-Field MRI with current and future specific focus on (1) pediatric whole-body cancer staging, (2) human connectome mapping for advanced understanding of neural connectivity in neurodegenerative and neurocognitive disorders.

Current Role at Stanford


Research Associate

Honors & Awards


  • NIH K99/R00 award - "Human Connectome Mapping Using Ultra-High-Resolution MRI", National Institutes of Health - Career transition to academic independence (2017-2022)
  • 1st place in ISMRM annual meeting MR engineering competition, Toronto, Canada, ISMRM (2015)
  • Magna Cum Laude Oral Presentation Award, ISMRM (2015)
  • Stanford GRSL high-risk initiative grant: "Magnetogenetics: A Powerful Tool for Cancer Therapy", Stanford (2015)
  • Collaborative Research Grant -- Harvard University / Massachusetts General Hospital, Burroughs Wellcome Fund (2014-2015)
  • Stanford RSL award, Stanford Radiological Sciences Laboratory (2013)
  • Post-Doc Fellowship, NSERC (2012-2014)
  • Notable Services and Contributions towards the Advancement of IEEE, IEEE (2012)
  • MTT-S Graduate Fellowship, IEEE (2009)
  • 1st rank Québec-wide in Merit Scholarship Program for Foreign Students, FQRNT (2007-2010)
  • Numerous (5+) travel grants, various (2006-2013)
  • Best Paper Award, IEEE CCECE (2006)
  • DOC-Scholarship, Austrian Academy of Science (2005-2007)
  • Completed studies in mechatronics below minimum time with distinction, JK University Linz (2005)
  • Numerous (4+) awards for master thesis, Erwin Wenzel Foundation, BMGF, Tech2b, OeVE (2005)

Education & Certifications


  • Doctor of Philosophy, Ecole Polytechnique Montreal / Université de Montréal, RF/microwave engineering (2011)
  • Master of Engineering, Johannes Kepler Universitaet Linz, mechatronics (2005)

Projects


  • Acoustics and vibrations in head insert and body gradient coils for Ultra High-Field MRI

    Location

    Stanford University

  • Dielectric Shimming for Ultra High-Field MRI

    Location

    Stanford University

  • Combined RF-shim coil design for Ultra High-Field MRI

    Location

    Stanford University

  • In-vivo SAR mapping for Ultra High-Field MRI safety

    Location

    Stanford University

  • Magnetic Hyperthermia

    Location

    Stanford University

  • RF coil and electromagnetic modeling in MRI

    Location

    Stanford University

Patents


  • Simone Winkler, Brian Rutt, Paul Picot, Michael Thornton. "United StatesIn-Vivo Specific Absorption Rate Mapping using the Thermoacoustic Effect", May 7, 2014

Professional

Professional Affiliations and Activities


  • Chapter Head, ASCINA - Austrian Scientists & Scholars in North America (2015 - 2016)
  • Professional Engineer jun., Ordre des ingénieurs du Québec (2013 - 2015)
  • MR Engineering Study Group Trainee Chair, ISMRM (2016 - 2017)
  • Educational Session Organizer for the ISMRM 2016, Singapore, ISMRM (2015 - 2016)
  • Fully licensed professional engineer, P.Eng., Professional Engineers Ontario (2015 - Present)
  • Member, International Society for Magnetic Resonance in Medicine (ISMRM) (2013 - Present)
  • Chair, IEEE Women in Engineering Montreal (2011 - 2012)
  • Member, IEEE (2005 - Present)
  • Member, Austrian Academy of Science (2005 - Present)
  • Chair, OeH Erstsemestrigentutorium (Austrian academic association - chapter for new student support) (2002 - 2005)
  • Steering Committee Member, IEEE International Microwave Symposium 2012 (10000-15000 attendees) (2011 - 2012)
  • Reviewer, Artech House Book Publishers (2011 - Present)

Publications

All Publications


  • A Novel Performance-Prediction Model of Subharmonic Self-Oscillating Mixers 12th International Symposium on Antenna Technology and Applied Electromagnetics (ANTEM) and Canadian Radio Sciences (URSI/CNC) Winkler, S. A., Wu, K., Stelzer, A.
  • Accurate Vibroacoustic Simulations in High Performance Gradient Coils Winkler, S. A., Alejski, A., Wade, T., McKenzie, C., Rutt, B. K.
  • A Novel Multiple-Element Phased High-Order Subharmonic Self-Oscillating Mixer for Millimeter-Wave Receivers Winkler, S. A., Han, L., Wu, K., Stelzer, A.
  • Comparison of new element designs for combined RF-Shim arrays at 7T Winkler, S. A., Stockmann, J., Warr, P. A., Keil, B., Watkins, R. P., Wald, L. L., Rutt, B. K.
  • Voltage controlled oscillator with frequency tripler in MHMIC technology for V-Band applications Hofmann, M., Winkler, S. A., Wu, K., Koelpin, A.
  • A Traveling-Wave Approach to Acoustic Noise Reduction in MR Gradient Coils Winkler, S. A., Alejski, A., Wade, T., McKenzie, C., Rutt, B. K.
  • A Novel Balanced Third and Fourth Harmonic Self-Oscillating Mixer with High Conversion Gain 36th European Microwave Conference Winkler, S. A.
  • Optimized Fast High-Resolution Whole-Body Imaging Protocols for Clinical Oncologic PET/MRI Winkler, S. A., et al
  • 7T Diffusion Tensor Imaging of High Mechanical Stress Achilles Tendon-to-Bone Interface Winkler, S. A., et al
  • Optimized Dielectric Shimming in High-Field Magnetic Resonance Imaging: A Theoretical Approach Winkler, S. A., Sbrizzi, A., van den Berg, C. A., Luijten, P. R., Rutt, B. K.
  • The Open Source Imaging Initiative Winter, L., Han, H., Barghoorn, A., Hoffmann, W., Hetzer, S., Winkler, S. A., Wald, L. L., Webb, A., Blumler, P., Niendorf, T.
  • A Novel Hybrid Analysis Approach for Subharmonic Self-Oscillating Mixers Combining Volterra Series and Conversion Matrix Methods 37th European Microwave Integrated Circuit Conference 2007 Winkler, S. A., Wu, K., Stelzer, A.
  • Vibroacoustic Noise Reduction in High Performance Head Gradient Coils Using Ceramic Inserts Winkler, S. A., Alejski, A., Wade, T., McKenzie, C., Rutt, B. K.
  • A Novel Polarization Rotating Frequency Selective Surface Based on Substrate Integrated Waveguide Winkler, S. A., Hong, W., Bozzi, M., Wu, K.
  • Self-Oscillating Mixing Technique and its Application to Low-Cost Receiver Architectures IEEE Canadian Conference on Electrical and Computer Engineering CCECE 2006 Winkler, S. A., Wu, K., Stelzer, A. : 248–251
  • Practical Methods for Improved B1 -Homogeneity in 3T Breast Imaging Winkler, S. A., Rutt, B. K.
  • Time-Domain Microwave Cancer Screening: Optimized Pulse Shaping Applied to Realistically Shaped Breast Phantoms Porter, E., Santorelli, A., Winkler, S. A., Popovic, M.
  • Singly Balanced Mixer Using Substrate Integrated Waveguide Magic-T Structure Han, L., Wu, K., Winkler, S. A.
  • A Study on Frequency Scalability for Integrated Imaging Radiometer Receivers Based on Subharmonic Self-Oscillating Mixers International Symposium on Signals, Systems, and Electronics (ISSSE) 2007 Winkler, S. A., Wu, K., Stelzer, A.
  • Lorentz Damping and the Field Dependence of Gradient Coil Vibroacoustics Winkler, S. A., Alejski, A., Wade, T., McKenzie, C., Rutt, B. K.
  • Open Source Imaging Initiative (OSI²) – Update and Roadmap Winter, L., Winkler, S. A., et al
  • Flip Angle Inhomogeneity Constrained pTx Pulse Design for Minimum Peak Local SAR Pendse, M., Winkler, S. A., Rutt, B. K.
  • Recent Progress in Ultra-Wideband Breast Cancer Detection Winkler, S. A., Porter, E., Santorelli, A., Coates, M., Popovic, M.
  • Direct SAR Mapping by Thermoacoustic Imaging: Experimental Proof-of-Concept Winkler, S. A., Picot, P., Thornton, M., Rutt, B. K.
  • Measurement and Modeling of LNA Based on Load-Pull System Zeng, X. B., Winkler, S. A., Wu, K., Ye, Y., Liu, T. J., He, J. M.
  • Direct SAR Mapping by Thermoacoustic Imaging: A Feasibility Study Winkler, S. A., Picot, P., Thornton, M., Rutt, B. K.
  • A Novel Technique for Millimeter-Wave Receivers Using Multiple-Element High-Order Subharmonic Self-Oscillating Mixers 2008 Global Symposium on Millimeter-Waves Winkler, S. A., Han, L., Wu, K., Stelzer, A.
  • Modular And Versatile Multi-Row Transmit Array Based On A Novel Decoupled Coil Element Stara, R., Winkler, S. A., Watkins, R. D., Retico, A., Tosetti, M., Rutt, B. K.
  • Novel Compact and Broadband Interconnects based on Ridge Substrate Integrated Waveguide Bozzi, M., Winkler, S. A., Wu, K.
  • A Novel Hybrid Analysis Approach for Subharmonic Self-Oscillating Mixers Combining Volterra Series and Conversion Matrix Methods Proc. 37th European Microwave Conference 2007 Winkler, S. A., Wu, K., Stelzer, A.
  • A Novel Balanced Third and Fourth Harmonic Self-Oscillating Mixer with High Conversion Gain 9th European Wireless Technology Conference Winkler, S. A., Wu, K., Stelzer, A.
  • Gradient and shim technologies for ultra high field MRI. NeuroImage Winkler, S. A., Schmitt, F., Landes, H., DeBever, J., Wade, T., Alejski, A., Rutt, B. K. 2016

    Abstract

    Ultra High Field (UHF) MRI requires improved gradient and shim performance to fully realize the promised gains (SNR as well as spatial, spectral, diffusion resolution) that higher main magnetic fields offer. Both the more challenging UHF environment by itself, as well as the higher currents used in high performance coils, require a deeper understanding combined with sophisticated engineering modeling and construction, to optimize gradient and shim hardware for safe operation and for highest image quality. This review summarizes the basics of gradient and shim technologies, and outlines a number of UHF-related challenges and solutions. In particular, Lorentz forces, vibroacoustics, eddy currents, and peripheral nerve stimulation are discussed. Several promising UHF-relevant gradient concepts are described, including insertable gradient coils aimed at higher performance neuroimaging.

    View details for DOI 10.1016/j.neuroimage.2016.11.033

    View details for PubMedID 27915120

  • On the accurate analysis of vibroacoustics in head insert gradient coils. Magnetic resonance in medicine Winkler, S. A., Alejski, A., Wade, T., McKenzie, C. A., Rutt, B. K. 2016

    Abstract

    To accurately analyze vibroacoustics in MR head gradient coils.A detailed theoretical model for gradient coil vibroacoustics, including the first description and modeling of Lorentz damping, is introduced and implemented in a multiphysics software package. Numerical finite-element method simulations were used to establish a highly accurate vibroacoustic model in head gradient coils in detail, including the newly introduced Lorentz damping effect. Vibroacoustic coupling was examined through an additional modal analysis. Thorough experimental studies were used to validate simulations.Average experimental sound pressure levels (SPLs) and accelerations over the 0-3000 Hz frequency range were 97.6 dB, 98.7 dB, and 95.4 dB, as well as 20.6 g, 8.7 g, and 15.6 g for the X-, Y-, and Z-gradients, respectively. A reasonable agreement between simulations and measurements was achieved. Vibroacoustic coupling showed a coupled resonance at 2300 Hz for the Z-gradient that is responsible for a sharp peak and the highest SPL value in the acoustic spectrum.We have developed and used more realistic multiphysics simulation methods to gain novel insights into the underlying concepts for vibroacoustics in head gradient coils, which will permit improved analyses of existing gradient coils and novel SPL reduction strategies for future gradient coil designs. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

    View details for DOI 10.1002/mrm.26543

    View details for PubMedID 27859549

  • Direct SAR mapping by thermoacoustic imaging: A feasibility study. Magnetic resonance in medicine Winkler, S. A., Picot, P. A., Thornton, M. M., Rutt, B. K. 2016

    Abstract

    To develop a new method capable of directly measuring specific absorption rate (SAR) deposited in tissue using the thermoacoustic signal induced by short radiofrequency (RF) pulse excitation.A detailed model based on the thermoacoustic wave generation and propagation is presented.We propose a new concept for direct measurement of SAR, to be used as a safety assessment/monitoring tool for MRI. The concept involves the use of short bursts of RF energy and the measurement of the resulting thermoacoustic excitation pattern by an array of ultrasound transducers, followed by image reconstruction to yield the 3D SAR distribution. We developed a simulation framework to model this thermoacoustic SAR mapping concept and verified the concept in vitro.Simulations show good agreement between reconstructed and original SAR distributions with an error of 4.2, 7.2, and 8.4% of the mean SAR values in axial, sagittal, and coronal planes and support the feasibility of direct experimental mapping of SAR distributions in vivo. The in vitro experiments show good agreement with theory (r(2)  = 0.52).A novel thermoacoustic method for in vivo mapping of local SAR patterns in MRI has been proposed and verified in simulation and in a phantom experiment. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

    View details for DOI 10.1002/mrm.26517

    View details for PubMedID 27779779

  • On the Accurate Analysis of Vibroacoustics in Head Insert Gradient Coils Magnetic Resonance in Medicine Winkler, S. A., Alejski, A., Wade, T., McKenzie, C., Rutt, B. K. 2016

    View details for DOI 10.1002/mrm.26543

  • Practical Methods for Improving B-1(+) Homogeneity in 3 Tesla Breast Imaging JOURNAL OF MAGNETIC RESONANCE IMAGING Winkler, S. A., Rutt, B. K. 2015; 41 (4): 992-999

    Abstract

    To improve image contrast and B1+ field homogeneity in 3 Tesla (T) breast MR.Two practical B1+ shimming methods for 3T breast MR are presented; low-cost passive shimming using local pads of high dielectric permittivity (εr from 0 to 100), and two-channel radiofrequency (RF) shimming (adjusting Q-I amplitude ratios and phase differences of 0 to -4 dB and 90 to 45 degrees), as well as a combination of both methods. The technique has been studied both in simulation using a numerical body model with added mammary tissue and in vivo in six subjects.Large improvements are observed with both methods, leading to a decrease in left-right B1+ asymmetry ratio of 1.24 to 1.00 (simulation) and from 1.26 to 1.01 (in vivo). RF safety was not adversely affected.Both RF shimming and dielectric shimming were shown to improve inhomogeneity in the B1+ field in 3T breast MR. J. Magn. Reson. Imaging 2015;41:992-999. © 2014 Wiley Periodicals, Inc.

    View details for DOI 10.1002/jmri.24635

    View details for Web of Science ID 000351521700016

    View details for PubMedID 24723508

  • Optimized Dielectric Shimming in High-Field Magnetic Resonance Imaging: A Theoretical Approach Scattering by Aggregates on Surfaces Winkler, S. A., Sbrizzi, A., van den Berg, C. A., Luijten, P. R., Rutt, B. K. edited by Wriedt, T., Eremin, Y. 2014: 70–73
  • A Low-Power Third-Harmonic Self-Oscillating Mixer Using Multi-Harmonic Load IEEE Microwave and Wireless Component Letters Chiu, L., Winkler, S. A., Xue, Q., Chan, C. H., Wu, K. 2012; 22 (7): 375-377
  • Passive Millimeter-Wave Imaging Based On Subharmonic Self-Oscillating Mixing Winkler, S. A. PhD Thesis. Ecole Polytechnique Montreal. 2011
  • Polarization Rotating Frequency Selective Surfaces Based on Substrate Integrated Waveguide Technology IEEE Transactions on Antennas and Propagation Winkler, S. A., Hong, W., Bozzi, M., Wu, K. 2010; 58 (4): 1202-1213
  • Broadband and Compact Ridge Substrate Integrated Waveguides IET Microwaves Bozzi, M., Winkler, S. A., Wu, K. 2010; 4 (11): 1965-1973
  • Ultra-High-Order Self-Oscillating Mixers based on a Multiple-Element Technique Electronics Letters Winkler, S. A., Wu, K., Stelzer, A. 2009; 45 (25)
  • PAST – Passive Adaptive Imaging System for Transportation European Microwave Week 2008 Winkler, S. A., Montagna, M. 2008
  • Integrated Receiver Based on a High- Order Subharmonic Self-Oscillating Mixer IEEE Transactions on Microwave Theory and Techniques Winkler, S. A., Wu, K., Stelzer, A. 2007; 54
  • Research and Development of Innovative Millimeter-Wave Imaging Systems Austrian Academy of Science Winkler, S. A., Wu, K., Stelzer, A. 2006
  • Self-oscillating mixing technique and its application to low-cost receiver architectures IEEE Canadian Journal of Electrical and Computer Engineering Winkler, S. A., Wu, K., Stelzer, A. 2006; 31 (4): 181-184
  • Design of a Novel Balanced High-Order Subharmonic Self-Oscillating Mixer Electronics Letters Winkler, S. A., Wu, K., Stelzer, A. 2006; 42 (24): 1405-1406
  • High-Speed DDS-controlled radar system for the identification of Surface Acoustic Wave Tags during translational motion Winkler, S. A. Master Thesis. Johannes Kepler University of Linz, Austria. 2005
  • Auswertung und Ansteuerung eines FSCW-Radars zur Codeidentifikation von SAW-Tags Winkler, S. A. Bachelor Thesis. Johannes Kepler University of Linz, Austria. 2004
  • Spezielle Relativitätstheorie: Eine Auseinandersetzung mit Einsteins Originalarbeit, 1905 Winkler, S. A. Scholarly thesis. Austria. 2000