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My primary research interest is evaluating whether vitamin D supplementation can positively affect consequences of the metabolic syndrome in overweight and obese adolescents. Other research interests include evaluating the efficacy and biochemical profiles of various types of estrogen replacement in adolescent females.
Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
To directly compare the safety (by laboratory evaluation) and efficacy (feminization and
growth) of three commonly used estrogen preparations in adolescent patients with ovarian
failure, either due to congenital causes (Turner syndrome) or medical therapies. We
hypothesize that transdermal estrogen will have equivalent efficacy and a more favorable
safety profile in comparison with conventional oral estrogen replacement.
Stanford is currently not accepting patients for this trial.
For more information, please contact Sejal Shah, 6507235791.
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Effect of Vitamin D Supplementation on Inflammation and Cardiometabolic Risk Factors in Obese Adolescents
Large studies of children show that over half of the children in the United States of America
do not have enough vitamin D stored in their bodies. In children who are overweight or obese,
the percentage of children who do not have enough vitamin D is even higher.
Vitamin D is essential for the body to maintain normal calcium levels and strong bones.
Recent research shows that through the actions of inflammatory markers, levels in the blood
that measure inflammation in the body, vitamin D plays many other important roles in the body
like helping to regulate the immune system, blood sugar levels, blood pressure, and body fat.
The purpose of this study is to determine the effect of vitamin D supplementation on
inflammatory markers in obese and overweight adolescents. As a secondary goal, we would like
to evaluate cardiometabolic risk factors and the correlation between body mass index, vitamin
D stores and inflammatory cytokines.
In an observed, randomized controlled trial over 6 months we will provide observed vitamin D
supplementation or placebo to healthy obese and overweight adolescents and measure changes in
inflammatory markers, lipids, blood pressure, and mean blood sugars. We hypothesize that
administration of vitamin D to these patients will improve their inflammatory profile and
cardiometabolic risk factors (blood glucose, blood pressure, and lipid profile).