Roham Zamanian

Professor of Medicine (Pulmonary and Critical Care Medicine)

Bio

Dr. Roham Zamanian specializes in the treatment of pulmonary hypertension, right heart failure, and pulmonary embolism. He has more than 13 years of sub-specialty experience in pulmonary vascular diseases. Dr. Zamanian is considered one of the leading national experts in clinical trials and drug development for pulmonary hypertension.

Clinical Focus

Pulmonary Hypertension
pulmonary vascular diseases
pulmonary embolism
right heart failure
Pulmonology (Lung) and Critical Care
Pulmonary Disease

Academic Appointments

Professor - University Medical Line, Medicine - Pulmonary, Allergy & Critical Care Medicine
Member, Cardiovascular Institute
Member, Wu Tsai Human Performance Alliance

Administrative Appointments

Director, Adult Pulmonary Hypertension Service, Vera Moulton Wall Center for Pulmonary Vascular Disease (2007 - Present)
Clinical Director, VMWC Pulmonary Hypertension Database, Vera Moulton Wall Center for Pulmonary Vascular Disease (2006 - Present)

Honors & Awards

Howard Huges Summer Fellowship, Harvard School of Medicine (1992 & 1993)
Ralph Waldo Gerard Award for Outstanding Researcher, University of California, Irvine School of Biological Sciences (1994)
Excellence in Research Award, University of California, Irvine School of Biological Sciences (1995)
Case Presentation Award, ACCP - Chest 2000 (2000)
Resident Research Presentation Award, Univ of Calif, Irvine Medical Center - Dept of Medicine (2001)
Fellow of the Year, Univ of Califronia, Irvine Medical Center (2002-2003)
Young Investigator Career Development Award, Entelligence Actelion Young Investigators Program (2006-2007)
Faculty Teaching Award, Dept of Medicine, Stanford (2007)
Fellow of the American College of Chest Physicians, American College of Chest Physicians (2008)

Boards, Advisory Committees, Professional Organizations

Scientific Advisory Board, PHaware (2016 - Present)

Professional Education

Board Certification: American Board of Internal Medicine, Pulmonary Disease (2018)
Fellowship: Stanford University Pulmonary and Critical Care Fellowship (2006) CA
Medical Education: UC Irvine School of Medicine (1999) CA
Fellowship: Stanford University School of Medicine (2005) CA
Fellowship: University of Irvine Medical Center (2003) CA
Residency: University of Irvine Medical Center (2002) CA
Internship: University of Irvine Medical Center (2000) CA
Super-Fellowship, Stanford University, Pulmonary Vascular Disease (2006)
Fellowship, Stanford University, Pulmonary & Critical Care (2005)
Fellowship, UCI Medical Center, Pulmonary & Critical Care (2003)
Residency, UCI Medical Center, Internal Medicine (2002)
MD, University of California, Irvine, Medicine (1999)
BS, University of California, Irvine, Biological Sciences (1994)

Community and International Work

Blue Lips Foundation

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US

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true

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PHaware

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Pulmonary Hypertension Patients

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International

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Member PHA Scientific Leadership Council

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Pulmonary Hypertension Association

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International

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Patents

Edda Spiekerkoetter, Marlene Rabinovitch, Roham Zamanian. "United StatesFK506 for treatment of PAH", Leland Stanford Junior University

Contact

Academic roham.zamanian@stanford.edu

Clinical Pulmonary and Critical Care 300 Pasteur Dr A251 MC 5221 Stanford CA 94305 Tel: (650) 723-6381 Fax: (650) 725-5489

Current Research and Scholarly Interests

1. Development and evaluation of prognostic and diagnostic integral biomarkers in PAH.

2. Prevalence and Treatment of Insulin Resistance in PAH.

3. Role of inflammation and proteomic signature in PAH

4. Development of novel therapeutics (bench to bedside) including FK506 & Elastase Inhibition in PAH.

5. Assessment of Vasoreactivity (gain and loss) in pulmonary arterial hypertension

6. Assessment of microvascular function in PAH.

Clinical Trials

Pulmonary Hypertension Association Registry Recruiting
More
The PHA Registry (PHAR) is a national study about people who have pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). PHAR collects information from people with PAH and CTEPH who are cared for in participating PHA-accredited Pulmonary Hypertension Care Centers throughout the U.S. PHAR will determine how people with PAH and CTEPH are evaluated, tested, and treated, and will observe how well these participants do. The goal is to see if people with PH are treated according to recommended guidelines, and to see if there are certain factors that can lead to better or worse outcomes. PHAR will include information about people with PAH and CTEPH in the U.S. who are seen at participating PHA-accredited PH Care Centers. PHAR contains data about patient care and outcomes. Specifically, data in the PHAR includes information on diagnosis; clinical status; socioeconomic status; diagnosis test results; body size; treatment information; interest in participating in clinical trials; family health and social history; and information about smoking, alcohol, or drug use. Participants are followed over time, and provide updates such as changes in therapy, how often participants need to go to the hospital, and survival. Such information may help healthcare providers provide better care.
Lead Sponsor
Stanford Investigators
- Roham Zamanian
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OPsumit USers Registry Recruiting
More
Prospective observational drug registry developed to characterize the safety profile (including primarily potential serious hepatic risks) and to describe clinical characteristics and outcomes of patients newly treated with Opsumit in the post-marketing setting.
Lead Sponsor
Stanford Investigators
- Roham Zamanian
View full details
U.S. CTEPH Registry Recruiting
More
The U.S. CTEPH Registry is a multicenter, observational, U.S.-based study of the clinical course and treatment of patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH), WHO Group IV Classification for Pulmonary Hypertension. The mission of the Registry will be to promote a greater understanding of the prevalence, pathophysiology, evaluation, and treatment of patients with CTEPH through shared information, education, and collaborative investigation among pulmonary hypertension (PH) centers of excellence throughout the U.S.
Lead Sponsor
Stanford Investigators
- Roham Zamanian
View full details
Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH) Not Recruiting
More
Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is a serious, life-threatening manifestation of systemic sclerosis (SSc), an autoimmune disease of the connective tissue characterized by scarring (fibrosis) and atrophy of the skin, joints and tendons, skeletal muscles, and internal organs, and immunological disturbances. One-year survival for patients with SSc-PAH ranges from 50-81%. There is currently no cure for SSc-PAH and treatment is limited to vasodilator therapy used in all forms of PAH. In recent studies, immunotherapy was shown to be effective in treating SSc-interstitial lung disease, another serious, life-threatening manifestation of SSc. In addition, there are compelling pre-clinical data and anecdotal clinical reports that suggest modulation of the immune system may be an effective strategy for treating SSc-PAH. To test this approach, this trial will determine if rituximab, an immunotherapy, has a marked beneficial effect on clinical disease progression, with minimal toxicity, in patients with SSc-PAH when compared to placebo.

Stanford is currently not accepting patients for this trial. For more information, please contact Val Scott, 650-725-8082.
Lead Sponsor
Stanford Investigators
View full details

2023-24 Courses

Independent Studies
- Directed Reading in Medicine
  MED 299 (Aut, Win, Spr)
- Early Clinical Experience in Medicine
  MED 280 (Aut, Win, Spr)
- Graduate Research
  MED 399 (Aut, Win, Spr)
- Medical Scholars Research
  MED 370 (Aut, Win, Spr)
- Undergraduate Research
  MED 199 (Aut, Win, Spr)

Stanford Advisees

Postdoctoral Faculty Sponsor
Clancy Dennis, Jonathan Moore, Srikanth Reddi
Postdoctoral Research Mentor
Clancy Dennis

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Roham Zamanian

Professor of Medicine (Pulmonary and Critical Care Medicine)

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Stanford Investigators

Stanford Investigators

Stanford Investigators

Stanford Investigators

2023-24 Courses

Stanford Advisees