Bio

Clinical Focus


  • Pancreatic Cancer
  • Cancer > Cutaneous (Dermatologic) Oncology
  • Cancer > GI Oncology
  • Gastrointestinal Cancers
  • Melanoma Surgery
  • Gastrointestinal Cancers - Surgical Oncology
  • General Surgery
  • Endocrine - Surgery
  • Pancreatic Cancer - Surgery
  • Pancreas Surgery

Academic Appointments


Administrative Appointments


  • Chief, Division of General Surgery, Stanford University School of Medicine (2000 - 2006)
  • Director, General Surgery Residency Program, Stanford University School of Medicine (2000 - 2009)
  • Johnson & Johnson Distinguished Professor, Stanford University School of Medicine (2000 - Present)

Honors & Awards


  • The John C. Gienapp Award, Accreditation Council for Graduate Medical Education (ACGME) (2012)
  • The Parker J. Palmer Courage to Teach Award, Accreditation Council for Graduate Medical Education (ACGME) (2006)
  • The Wakely Prize - Runner up, The Lancet (1997)
  • Cum Laude Graduation Honors, Fordham University (1964)

Professional Education


  • Medical Education:Yale University School of Medicine (1968) CT
  • Residency:Yale - New Haven Hospital (1973) CT
  • Board Certification: General Surgery, American Board of Surgery (1974)
  • Internship:Yale - New Haven Hospital (1969) CT
  • MD, Yale Medical School (1968)
  • Fellow, American Cancer Society (1971)

Community and International Work


  • Board of Directors of Hopital Albert Schweitzer, Haiti

    Topic

    International Health in Haiti

    Location

    International

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    Yes

Research & Scholarship

Current Research and Scholarly Interests


Application of Micro/Nanotechnology to Biological Systems.

Clinical Trials


  • Trilogy Stereotactic Body Radiotherapy for Pancreatic Cancer Not Recruiting

    This study will assess the efficacy of treating locally advanced pancreatic cancer using a linear accelerator designed for image-guided radiotherapy

    Stanford is currently not accepting patients for this trial. For more information, please contact Jeff Kim, (650) 498 - 7703.

    View full details

Teaching

2013-14 Courses


Publications

Journal Articles


  • Symbiotic or Parasitic? A Review of the Literature on the Impact of Fellowships on Surgical Residents ANNALS OF SURGERY Plerhoples, T. A., Greco, R. S., Krummel, T. M., Melcher, M. L. 2012; 256 (6): 904-908

    Abstract

    We conducted a systematic review of published literature to gain a better understanding of the impact of advanced fellowships on surgical resident training and education.As fellowship opportunities rise, resident training may be adversely impacted.PubMed, MEDLINE, Scopus, BIOSIS, Web of Science, and a manual search of article bibliographies. Of the 139 citations identified through the initial electronic search and screened for possible inclusion, 23 articles were retained and accepted for this review. Data were extracted regarding surgical specialty, methodology, sample population, outcomes measured, and results.Eight studies retrospectively compared the eras before and after the introduction of a fellowship or trended data over time. Approximately half used data from a single institution, whereas the other half used some form of national data or survey. Only 3 studies used national case data. Fourteen studies looked at general surgery, 6 at obstetrics-gynecology, 2 at urology, and 1 at otolaryngology. Only one study concluded that fellowships have a generally positive impact on resident education, whereas 9 others found a negative impact. The remaining 13 studies found mixed results (n = 6) or minimal to no impact (n = 7).The overall impact of advanced surgical fellowships on surgical resident education and training remains unclear, as most studies rely on limited data of questionable generalizability. A careful study of the national database of surgery resident case logs is essential to better understand how early surgical specialization and fellowships will impact the future of general surgery education.

    View details for DOI 10.1097/SLA.0b013e318262edd5

    View details for Web of Science ID 000312261000012

    View details for PubMedID 22968071

  • Bilateral Adrenal Medullary Hyperplasia Associated With an SDHB Mutation JOURNAL OF CLINICAL ONCOLOGY Grogan, R. H., Pacak, K., Pasche, L., Huynh, T. T., Greco, R. S. 2011; 29 (8): E200-E202

    View details for DOI 10.1200/JCO.2010.32.2156

    View details for Web of Science ID 000288161000006

    View details for PubMedID 21172883

  • Massive Extra-adrenal Retroperitoneal Paraganglioma: Pre-operative Embolization and Resection DIGESTIVE DISEASES AND SCIENCES Rosing, J. H., Jeffrey, R. B., Longacre, T. A., Greco, R. S. 2009; 54 (8): 1621-1624

    View details for DOI 10.1007/s10620-009-0804-6

    View details for Web of Science ID 000267485400002

    View details for PubMedID 19408117

  • Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers BIOMEDICAL MICRODEVICES Ryu, W. H., Vyakarnam, M., Greco, R. S., Prinz, F. B., Fasching, R. J. 2007; 9 (6): 845-853

    Abstract

    A programmable and biodegradable drug delivery device is desirable when a drug needs to be administered locally. While most local drug delivery devices made of biodegradable polymers relied on the degradation of the polymers, the degradation-based release control is often limited by the property of the polymers. Thus, we propose micro-geometry as an alternative measure of controlling drug release. The proposed devices consist of three functional layers: diffusion control layer via micro-orifices, diffusion layer, and drug reservoir layers. A micro-fabrication technology was used to shape an array of micro-orifices and micro-cavities in 85/15PLGA layers. A thin layer of fast degrading 50/50PLGA was placed as the diffusion layer between the 85/15PLGA layers to prevent any burst-type release. To modulate the release of the devices, the dimension and location of the micro-orifices were varied and the responding in vitro release response of tetracycline was monitored over 2 weeks. The release response to the different micro-geometry was prominent and further analyzed by FEM simulation. Comparison of the experiments to the simulated results identified that the variation of micro-geometry influenced also the volume-dependent degradation rate and induced the osmotic pressure.

    View details for DOI 10.1007/s10544-007-9097-8

    View details for Web of Science ID 000250462200009

    View details for PubMedID 17577671

  • The construction of three-dimensional micro-fluidic scaffolds of biodegradable polymers by solvent vapor based bonding of micro-molded layers BIOMATERIALS Ryu, W., Min, S. W., Hammerick, K. E., Vyakarnam, M., Greco, R. S., Prinz, F. B., Fasching, R. J. 2007; 28 (6): 1174-1184

    Abstract

    It is increasingly important to control cell growth into and within artificial scaffolds. Tissues such as skin, blood vessels, and cartilage have multi-layer structures with different cells in each layer. With the aid of micro-fabrication technology, a novel scaffolding method for biodegradable polymers such as polylactic acid (PLA), polyglycolic acid (PGA), and the copolymers poly(lactide-co-glycolide)(PLGA), was developed to construct three-dimensional multi-layer micro-fluidic tissue scaffolds. The method emphasizes micro-fluidic interconnections between layers within the scaffolds and maintenance of high-resolution geometries during the bonding process for the creation of multi-layered scaffolds. Micro-holes (10-100 microm), micro-channels, and micro-cavities were all created by micro-molding. Solvent-vapor based bonding of micro-molded layers preserved 20 microm sized structures. Sample scaffolds were constructed for purposes such as channel-directed cell growth and size-based cell sorting. Further extension of these techniques to create a micro-vascular network within or between layers is possible. Culturing of human coronary artery endothelial cells (HCAECs) on the sample scaffolds demonstrated the biocompatibility of the developed process and the strong influence of high-resolution micro-geometries on HCAEC growth.

    View details for DOI 10.1016/j.biomaterials.2006.11.002

    View details for Web of Science ID 000243219000028

    View details for PubMedID 17126395

  • Micro Fabrication Technology for Biodegradable Polymers for Interconnecting Microstructures Ryu WonHyoung, Fasching R, Vyakarnam M, Prinz F, Greco R S 2006
  • Nanotechnology Applied to Biological Systems Greco RS. 2004
  • Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Wapnir, I. L., van de Rijn, M., Nowels, K., Amenta, P. S., Walton, K., Montgomery, K., Greco, R. S., Dohan, O., Carrasco, N. 2003; 88 (4): 1880-1888

    Abstract

    Extrathyroidal cancers could potentially be targeted with (131)I, if the Na(+)/I(-) symporter (NIS) were functional. Using immunohistochemical methods we probed 1278 human samples with anti-NIS antibody, including 253 thyroid and 169 breast conventional whole tissue sections (CWTS). Four high density tissue microarrays containing a wide variety of breast lesions, normal tissues, and carcinoma cores were tested. The results of the normal microarray were corroborated in 50 CWTS. Nineteen of 34 normal tissues, including bladder, colon, endometrium, kidney, prostate, and pancreas, expressed NIS. Nineteen of 25 carcinomas demonstrated NIS immunopositivity; 55.7% of 479 carcinoma microarray cores expressed NIS, including prostate (74%), ovary (73%), lung (65%), colon (62.6%), and endometrium (56%). NIS protein was present in 75% benign thyroid lesions, 73% thyroid cancers, 30% normal-appearing, peritumoral breasts, 88% ductal carcinomas in situ, and 76% invasive breast carcinoma CWTS. Comparatively, breast microarray cores had lower immunoreactivity. Plasma membrane immunopositivity was confirmed in thyrocytes, salivary ductal, gastric mucosa, and lactating mammary cells. In other tissues, immunoreactivity was predominantly intracellular, particularly in malignant lesions. Thus, NIS is present in many normal epithelial tissues and is predominantly expressed intracellularly in many carcinomas. Elucidating the regulatory mechanisms that render NIS functional in extrathyroidal carcinomas may make (131)I therapy feasible.

    View details for DOI 10.1210/jc.2002-021544

    View details for Web of Science ID 000182211000072

    View details for PubMedID 12679487

  • Neutrophil survival on biomaterials is determined by surface topography. J Vasc Surg. Chang S, Popowich Y, Greco RS, Haimovich B. 2003; 37 (5): 1082-90
  • PMN exposure to a quantified bacterial load leads to a rapid, non-apoptotic cell death. Surg Forum Popowich Y, Greco RS, Haimovich B. 2001; 87 (LII): 344-346
  • Dacron and ePTFE-associated neutrophil death is linked to surface to surface topography and involves activation of SRC and PYK tyrosine kinases. Surg Forum Chang SS, Haimovich B, Greco RS. 2000; 86 (LI): 404-407
  • The cardboard box JAMA Greco RS. 2000; 284 (5): 534
  • Neutrophil Adhesion to vascular prosthetic surfaces triggers non-apoptotic cell death. Ann Surg Nadzam G, De La Cruz C, Greco RS, Haimovich B. 2000; 231 (4): 587-599

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