Bio

Honors & Awards


  • NIH T32 Postdoctoral Fellowship, Stanford Cancer Imaging Training (SCIT) (2014)
  • Predoctoral Fellowship Award, University of Connecticut (2014)
  • USA PR, Extraordinary Petition (2013)
  • Doctoral Dissertation Fellowship Award, University of Connecticut (2013)
  • Travel Award, SPIE Photonics West 2013 (2013)
  • Predoctoral Fellowship Award, University of Connecticut (2013)
  • 1st Place, Crow Innovation Prize, University of Connecticut (2012)
  • Predoctoral Fellowship Award, University of Connecticut (2011)

Professional Education


  • Doctor of Philosophy, University of Connecticut (2014)

Stanford Advisors


Publications

Journal Articles


  • Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization JOURNAL OF BIOMEDICAL OPTICS Alqasemi, U., Li, H., Yuan, G., Kumavor, P., Zanganeh, S., Zhu, Q. 2014; 19 (7)

    Abstract

    Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.

    View details for DOI 10.1117/1.JBO.19.7.076020

    View details for Web of Science ID 000340490400044

    View details for PubMedID 25069009

  • Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography JOURNAL OF BIOMEDICAL OPTICS Xu, C., Kumavor, P. D., Alqasemi, U., Li, H., Xu, Y., Zanganeh, S., Zhu, Q. 2013; 18 (12)

    Abstract

    To overcome the intensive light scattering in biological tissue, diffuse optical tomography (DOT) in the near-infrared range for breast lesion detection is usually combined with other imaging modalities, such as ultrasound, x-ray, and magnetic resonance imaging, to provide guidance. However, these guiding imaging modalities may depend on different contrast mechanisms compared to the optical contrast in the DOT. As a result, they cannot provide reliable guidance for DOT because some lesions may not be detectable by a nonoptical modality but may have a high optical contrast. An imaging modality that relies on optical contrast to provide guidance is desirable for DOT. We present a system that combines a frequency-domain DOT and real-time photoacoustic tomography (PAT) systems to detect and characterize deeply seated targets embedded in a turbid medium. To further improve the contrast, the exogenous contrast agent, indocyanine green (ICG), is used. Our experimental results show that the combined system can detect a tumor-mimicking phantom, which is immersed in intralipid solution with the concentrations ranging from 100 to 10 ?M and with the dimensions of 0.8 cm 0.8 cm 0.6 cm, up to 2.5 cm in depth. Mice experiments also confirmed that the combined system can detect tumors and monitor the ICG uptake and washout in the tumor region. This method can potentially improve the accuracy to detect small breast lesions as well as lesions that are sensitive to background tissue changes, such as the lesions located just above the chest wall.

    View details for DOI 10.1117/1.JBO.18.12.126006

    View details for Web of Science ID 000331706500027

    View details for PubMedID 24343437

  • Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates JOURNAL OF BIOMEDICAL OPTICS Xu, Y., Zanganeh, S., Mohammad, I., Aguirre, A., Wang, T., Yang, Y., Kuhn, L., Smith, M. B., Zhu, Q. 2013; 18 (6)

    Abstract

    Tumor hypoxia is a major indicator of treatment resistance to chemotherapeutic drugs, and fluorescence optical tomography has tremendous potential to provide clinically useful, functional information by identifying tumor hypoxia. The synthesis of a 2-nitroimidazole-indocyanine green conjugate using a piperazine linker (piperazine-2-nitroimidazole-ICG) capable of robust fluorescent imaging of tumor hypoxia is described. In vivo mouse tumor imaging studies were completed and demonstrate an improved imaging capability of the new dye relative to an earlier version of the dye that was synthesized with an ethanolamine linker (ethanolamine-2-nitroimidazole-ICG). Mouse tumors located at imaging depths of 1.5 and 2.0 cm in a turbid medium were imaged at various time points after intravenous injection of the dyes. On average, the reconstructed maximum fluorescence concentration of the tumors injected with piperazine-2-nitroimidazole-ICG was twofold higher than that injected with ethanolamine-2-nitroimidazole-ICG within 3 h postinjection period and 1.6 to 1.7 times higher beyond 3 h postinjection. The untargeted bis-carboxylic acid ICG completely washed out after 3 h postinjection. Thus, the optimal window to assess tumor hypoxia is beyond 3 h postinjection. These findings were supported with fluorescence images of histological sections of tumor samples and an immunohistochemistry technique for identifying tumor hypoxia.

    View details for DOI 10.1117/1.JBO.18.6.066009

    View details for Web of Science ID 000322341100051

    View details for PubMedID 23764695

  • The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging PHYSICAL CHEMISTRY CHEMICAL PHYSICS Abuteen, A., Zanganeh, S., Akhigbe, J., Samankumara, L. P., Aguirre, A., Biswal, N., Braune, M., Vollertsen, A., Roeder, B., Brueckner, C., Zhu, Q. 2013; 15 (42): 18502-18509

    View details for DOI 10.1039/c3cp52193a

    View details for Web of Science ID 000325728400021

  • Photoacoustic Imaging of Tumor Margins Enhanced by ICG Conjugated Single Wall Carbon Nanotubes JOURNAL OF BIOMEDICAL OPTICS Zanganeh, S., LI, H., Kumavor, P., Alqasemi, U., Zhu, Q. 2013
  • Fluorescence imaging of vascular endothelial growth factor in mice tumors using targeted liposome ICG probe OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE X Zanganeh, S., Xu, Y., Backer, M. V., Backer, J. M., Zhu, Q. 2013; 8578

    View details for DOI 10.1117/12.2007296

    View details for Web of Science ID 000326708600062

  • Characterization of Grain Size and Yield Strength in AISI 301 Stainless Steel Using Ultrasonic Attenuation Measurements JOURNAL OF NONDESTRUCTIVE EVALUATION Aghaie-Khafri, M., Honarvar, F., Zanganeh, S. 2012; 31 (3): 191-196
  • Correlation between ultrasonic velocity and solutionising time in Rene 80 superalloy MATERIALS SCIENCE AND TECHNOLOGY Aghaie-Khafri, M., Honarvar, F., Zangeneh, S. 2011; 27 (9): 1433-1435
  • Imaging tumor hypoxia by near-infrared fluorescence tomography JOURNAL OF BIOMEDICAL OPTICS Biswal, N. C., Pavlik, C., Smith, M. B., Aguirre, A., Xu, Y., Zanganeh, S., Kuhn, L. T., Claffey, K. P., Zhu, Q. 2011; 16 (6)

    Abstract

    We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using tumor cell lines and in vivo with tumor targeting in mice. The in vitro cell studies were performed to assess fluorescence labeling differences between hypoxia and normoxia conditions. When treated with the hypoxia probe, a fluorescence emission ratio of 2.5-fold was found between the cells incubated under hypoxia compared to the cells in normoxia condition. Hypoxia specificity was also confirmed by comparing the cells treated with indocyanine dye alone. In vivo tumor targeting in mice showed that the fluorescence signals measured at the tumor site were twice those at the normal site after 150 min post-injection of the hypoxia probe. On the other hand, the fluorescence signals measured after injection of indocyanine dye were the same at tumor and normal sites. In vivo fluorescence tomography images of mice injected with the hypoxia probe showed that the probe remained for more than 5 to 7 h in the tumors, however, the images of mice injected with indocyanine only dye confirmed that the unbound dye washed out in less than 3 h. These findings are supported with fluorescence images of histological sections of tumor samples using a Li-COR scanner and immunohistochemistry technique for tumor hypoxia.

    View details for DOI 10.1117/1.3589348

    View details for Web of Science ID 000293086800015

    View details for PubMedID 21721810

  • Hydrothermal synthesis and characterization of TiO2 nanostructures using LiOH as a solvent ADVANCED POWDER TECHNOLOGY Zanganeh, S., Kajbafvala, A., Zanganeh, N., Molaei, R., Bayati, M. R., Zargar, H. R., Sadrnezhaad, S. K. 2011; 22 (3): 336-339
  • Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system JOURNAL OF BIOMEDICAL OPTICS Kumavor, P. D., Xu, C., Aguirre, A., Gamelin, J., Ardeshirpour, Y., Tavakoli, B., Zanganeh, S., Alqasemi, U., Yang, Y., Zhu, Q. 2011; 16 (4)

    Abstract

    We present a photoacoustic tomography-guided diffuse optical tomography approach using a hand-held probe for detection and characterization of deeply-seated targets embedded in a turbid medium. Diffuse optical tomography guided by coregistered ultrasound, MRI, and x ray has demonstrated a great clinical potential to overcome lesion location uncertainty and to improve light quantification accuracy. However, due to the different contrast mechanisms, some lesions may not be detectable by a nonoptical modality but yet have high optical contrast. Photoacoustic tomography utilizes a short-pulsed laser beam to diffusively penetrate into tissue. Upon absorption of the light by the target, photoacoustic waves are generated and used to reconstruct, at ultrasound resolution, the optical absorption distribution that reveals optical contrast. However, the robustness of optical property quantification of targets by photoacoustic tomography is complicated because of the wide range of ultrasound transducer sensitivity, the orientation and shape of the targets relative to the ultrasound array, and the uniformity of the laser beam. We show in this paper that the relative optical absorption map provided by photoacoustic tomography can potentially guide the diffuse optical tomography to accurately reconstruct target absorption maps.

    View details for DOI 10.1117/1.3563534

    View details for Web of Science ID 000291031400017

    View details for PubMedID 21529079

  • A facile method to grow V-doped TiO2 hydrophilic layers with nano-sheet morphology MATERIALS LETTERS Bayati, M. R., Molaei, R., Zargar, H. R., Kajbafvala, A., Zanganeh, S. 2010; 64 (22): 2498-2501
  • CVD fabrication of carbon nanotubes on electrodeposited flower-like Fe nanostructures JOURNAL OF ALLOYS AND COMPOUNDS Zanganeh, S., Torabi, M., Kajbafvala, A., Zanganeh, N., Bayati, M. R., Molaei, R., Zargar, H. R., Sadrnezhaad, S. K. 2010; 507 (2): 494-497
  • Influence of nano boehmite on solid state reaction of alumina and magnesia JOURNAL OF ALLOYS AND COMPOUNDS Zargar, H. R., Bayati, M. R., Rezaie, H. R., Golestani-Fard, F., Molaei, R., Zanganeh, S., Kajbafvala, A. 2010; 507 (2): 443-447
  • Investigation on hydrophilicity of micro-arc oxidized TiO2 nano/micro-porous layers ELECTROCHIMICA ACTA Bayati, M. R., Molaei, R., Kajbafvala, A., Zanganeh, S., Zargar, H. R., Janghorban, K. 2010; 55 (20): 5786-5792
  • Microwave-assisted synthesis of narcis-like zinc oxide nanostructures JOURNAL OF ALLOYS AND COMPOUNDS Kajbafvala, A., Zanganeh, S., Kajbafvala, E., Zargar, H. R., Bayati, M. R., Sadrnezhaad, S. K. 2010; 497 (1-2): 325-329
  • Self-assembly of boehmite nanopetals to form 3D high surface area nanoarchitectures APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING Zanganeh, S., Kajbafvala, A., Zanganeh, N., Mohajerani, M. S., Lak, A., Bayati, M. R., Zargar, H. R., Sadrnezhaad, S. K. 2010; 99 (1): 317-321
  • MAO-synthesized Al2O3-supported V2O5 nano-porous catalysts: Growth, characterization, and photoactivity APPLIED SURFACE SCIENCE Bayati, M. R., Zargar, H. R., Molaei, R., Golestani-Fard, F., Zanganeh, N., Kajbafvala, A. 2010; 256 (12): 3806-3811
  • One step growth Of WO3-loaded Al2O3 micro/nano-porous films by micro arc oxidation COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS Bayati, M. R., Zargar, H., Molaei, R., Golestani-Fard, F., Kajbafvala, E., Zanganeh, S. 2010; 355 (1-3): 187-192
  • 3D bundles of self-assembled lanthanum hydroxide nanorods via a rapid microwave-assisted route JOURNAL OF ALLOYS AND COMPOUNDS Mazloumi, M., Shahcheraghi, N., Kajbafvala, A., Zanganeh, S., Lak, A., Mohajerani, M. S., Sadrnezhaad, S. K. 2009; 473 (1-2): 283-287
  • Nanostructure sword-like ZnO wires: Rapid synthesis and characterization through a microwave-assisted route JOURNAL OF ALLOYS AND COMPOUNDS Kajbafvala, A., Shayegh, M. R., Mazloumi, M., Zanganeh, S., Lak, A., Mohajerani, M. S., Sadrnezhaad, S. K. 2009; 469 (1-2): 293-297
  • Self-assembly of ZnO nanoparticles and subsequent formation of hollow microspheres JOURNAL OF ALLOYS AND COMPOUNDS Mazloumi, M., Taghavi, S., Arami, H., Zanganeh, S., Kajbafvala, A., Shayegh, M. R., Sadrnezhaad, S. K. 2009; 468 (1-2): 303-307
  • Ultrasonic induced photoluminescence decay in sonochemically obtained cauliflower-like ZnO nanostructures with surface 1D nanoarrays ULTRASONICS SONOCHEMISTRY Mazloumi, M., Zanganeh, S., Kajbafvala, A., Ghariniyat, P., Taghavi, S., Lak, A., Mohaierani, M., Sadrnezhaad, S. K. 2009; 16 (1): 11-14

    Abstract

    Cauliflower-like ZnO nanostructures with average crystallite size of about 55 nm which have surface one dimensional (1D) nanoarrays with 10 nm diameter were successfully fabricated through a simple sonochemical route. X-ray diffractometry (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and room temperature photoluminescence (PL) characterizations were performed to investigate the morphological and structural properties of the obtained nanostructures. It has been shown that the synthesized cauliflower-like ZnO nanostructures irradiated UV luminescence and a green peak in visible band. Ultrasonic post-treatment of the particles for about 2 h increased the density of surface defects resulted in an increase in the green emission intensity.

    View details for DOI 10.1016/j.ultsonch.2008.05.011

    View details for Web of Science ID 000259919600004

    View details for PubMedID 18603463

  • Rapid Formation of Mono-Dispersed Hydroxyapatite Nanorods with Narrow-Size Distribution via Microwave Irradiation JOURNAL OF THE AMERICAN CERAMIC SOCIETY Lak, A., Mazloumi, M., Mohajerani, M. S., Zanganeh, S., Shayegh, M. R., Kajbafvala, A., Arami, H., Sadrnezhaad, S. K. 2008; 91 (11): 3580-3584
  • Boehmite nanopetals self assembled to form rosette-like nanostructures MATERIALS LETTERS Mazloumi, M., Attarchi, M., Lak, A., Mohajerani, M. S., Kajbafvala, A., Zanganeh, S., Sadrnezhaad, S. K. 2008; 62 (26): 4184-4186
  • Self-Assembly of Dandelion-Like Hydroxyapatite Nanostructures Via Hydrothermal Method JOURNAL OF THE AMERICAN CERAMIC SOCIETY Lak, A., Mazloumi, M., Mohajerani, M., Kajbafvala, A., Zanganeh, S., Arami, H., Sadrnezhaad, S. K. 2008; 91 (10): 3292-3297
  • Self-assembled zinc oxide nanostructures via a rapid microwave-assisted route JOURNAL OF CRYSTAL GROWTH Mohajerani, M. S., Mazloumi, M., Lak, A., Kajbafvala, A., Zanganeh, S., Sadrnezhaad, S. K. 2008; 310 (15): 3621-3625
  • Formation of Lanthanum Hydroxide Nanostructures: Effect of NaOH and KOH Solvents International Journal of Engineering, Transactions B: Applications Zanganeh, S. 2008

Presentations


  • Accelerated PET/MR Staging of Children with Cancer

    Presented To

    Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL 2014

    Location

    USA

  • Biodistribution study of 2-nitroimidazole indocyanine green conjugate dye conjugates

    Hypoxia markers in previous studies are categorized by the nitroimidazole family. The nitroimidazole
    derivatives show a superior ability in selectively retaining in hypoxic tissues [1, 2]. Among all
    the imidazole compounds, 2-nitroimidazoles have higher electron affinities and are the most
    commonly used hypoxia markers when labeled with positron emission tomography (PET) radionuclides
    [3,4]. Problems associated with the PET modality, including a limited resolution, high background
    counts, the use of radioactive tracers and high cost for routine clinical use, raise a need ...

    Time Period

    4/26/2014 - Present

    Presented To

    Biomedical Optics

    Location

    FLORIDA

  • ?Artifact Reduction in Small Animal Experiments Using Diffuse Optical Tomography and Photoacoustic Tomography with Exogenous Contrast Agents

    Presented To

    Biomedical Optics, BM3A. 56, USA 2014

    Location

    USA

  • Cerebral Oxygenation, Blood Flow, and Oxygen Metabolism During the First Days of Life

    Presented To

    Biomedical Optics, BM3A. 18

    Location

    USA

  • Importance of Free Space Modelling on Quantitative Non-Contact Imaging

    Presented To

    Biomedical Optics, BM3A. 46

    Location

    USA

  • Fluorescence imaging of vascular endothelial growth factor in mice tumors using targeted liposome ICG probe

    Presented To

    SPIE BiOS 2013, San Francisco, California USA. 2013

    Location

    USA

  • Single wall carbon nanotube/bis carboxylic acid-ICG as a sensitive contrast agent for in vivo tumor imaging in photoacoustic tomography

    Presented To

    SPIE BiOS 2013, San Francisco, California USA. 2013.

    Location

    USA

  • Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates

    Presented To

    SPIE BiOS 2013, San Francisco, California USA. 2013

    Location

    USA

  • Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging

    Presented To

    SPIE BiOS 2013, San Francisco, California USA. 2013

    Location

    USA

  • Structurally modified indocyanine dyes and targeting cancerous tumors

    Presented To

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013

    Location

    USA

  • Porphyrin Derivatives as Exogeneous Contrast Agents

    Presented To

    Proc. SPIE (2012). San Francisco, California USA. 2012

    Location

    USA

  • Hypoxia targeted carbon nanotubes as a sensitive contrast agent for photoacoustic imaging of tumors

    Presented To

    Proc. SPIE 7899, 78991S (2011). San Francisco, California USA. 2011

    Location

    USA

  • Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system

    Presented To

    Proc. SPIE 7896, 789614 (2011). San Francisco, California USA. 2011

    Location

    USA

  • Tumor hypoxia fluorescence imaging using 2-nitroimidazole bis-carboxylic acid indocyanine dye conjugate

    Presented To

    Proc. SPIE 7896, 78962R (2011). San Francisco, California USA. 2011

    Location

    USA

  • The Effect of Current Type on Morphology, Chemical Composition, and Photocatalytic Activity of Nano/Micro Porous Micro Arc Oxidized Titania Layers

    Presented To

    Materials Science & Technology (MS&T), 2010 Conference & Exhibition, October 17-21, 2010, Houston, Texas, USA. 2010

    Location

    USA

  • On the Hydrophilicity of Micro Arc Oxidized V2O5-TiO2 Nano/Micro-Porous Layers

    Presented To

    Materials Science & Technology (MS&T), 2010 Conference & Exhibition, October 17-21, 2010, Houston, Texas, USA. 2010

    Location

    USA

  • How Hydrophilicity of the WO3-TiO2 Nano Porous Layers Is Influenced by the MAO-Parameters?

    Presented To

    Materials Science & Technology (MS&T), 2010 Conference & Exhibition, October 17-21, 2010, Houston, Texas, USA. 2010

    Location

    USA

  • How the Molybdenum Recovery Efficiency is Influenced by the Electrooxidation Key Parameters?

    Presented To

    Materials Science & Technology (MS&T), 2010 Conference & Exhibition, October 17-21, 2010, Houston, Texas, USA. 2010

    Location

    USA

  • Fabrication of Carbon Nanotubes on an Electrodeposited Nickel Nanostructures using chemical vapor deposition method

    Presented To

    Materials Science & Technology (MS&T), 2010 Conference & Exhibition, October 17-21, 2010, Houston, Texas, USA. 2010

    Location

    USA

  • Hydrothermal synthesis of TiO2 Nano particles in deferent concentrations of LiOH solutions

    Presented To

    International Conference of the European Ceramic Society, Proceedings of the 11th ECERS Conference, Krakow, Poland, PP 583-586, (2009)

    Location

    Poland

  • Self-assembly preparation of Flower-like Boehmite Nano-architectures

    Presented To

    International Conference of the European Ceramic Society, Proceedings of the 11th ECERS Conference, Krakow, Poland, PP 587-590, (2009)

    Location

    Poland

  • Boehmite nanopetals Self-assembled to form High Surface Area 3D Nano-Architectures

    Presented To

    Materials Research Society (2009), North Carolina Symposium, 2009, North Carolina State University (NCSU), Raleigh, NC 27695-7907, USA. 2009

    Location

    USA

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