Bio

Bio


Dr Peter van Roessel, M.D. Ph.D, completed his MD at Stanford University and his residency training in psychiatry at Columbia University and the New York-Presbyterian Hospital in New York City. Prior to joining the clinical faculty at Stanford, he worked for several years as Associate Director of the general research unit of the New York State Psychiatric Institute, a premier state-funded research hospital affiliated with Columbia University, where he provided clinical care for individuals participating in research studies across a spectrum of psychiatric illness, including treatment resistant mood disorders, anxiety disorders, psychosis and substance use disorders.

At Stanford, he sees adult mood and anxiety disorders outpatients through the Evaluations Clinic and Depression Clinic and participates in resident training and patient care as a supervisor in psychodynamic psychotherapy and as an attending physician in Continuity Clinic. As a member of the department's Rodriguez Translational Therapeutics Lab, he sees individuals with obsessive-compulsive spectrum disorders for evaluations and research-protocol driven clinical treatment, and contributes to clinical neuroscience studies pioneering rapid-acting interventions in OCD.

Dr van Roessel pursued research training basic neuroscience prior to his clinical training, completing an MPhil in Biology via the Open University, UK, for research performed at the Max Planck Institute for Developmental Biology in Tübingen Germany, and a PhD in molecular and developmental neurobiology in the laboratory of Dr Andrea Brand at the University of Cambridge, UK. More recently, he has contributed to work in the lab of Dr Julia Kaltschmidt (Sloan Kettering Institute, now Stanford) on studies of GABAergic/Glutamatergic interneuronal circuity in mouse. In the Rodriguez Lab, he is pursuing clinically-motivated research interests related to the nature and neural correlates of insight in obsessive-compulsive and related disorders. He has additionally received a 2018 NARSAD Young Investigator Award to pursue a novel glutamatergic rapid-acting treatment for OCD.

Clinical Focus


  • Psychiatry

Academic Appointments


  • Clinical Assistant Professor, Psychiatry and Behavioral Sciences

Professional Education


  • PhD Training:University of Cambridge (2003) United Kingdom
  • Board Certification: Psychiatry, American Board of Psychiatry and Neurology (2011)
  • Residency:New York Presbyterian Hospital - Columbia University (2011) NY
  • Medical Education:Stanford University School of Medicine (2007) CA

Publications

All Publications


  • Two-color GFP imaging demonstrates cell-autonomy of GAL4-driven RNA interference in Drosophila. Genesis (New York, N.Y. : 2000) Van Roessel, P., Hayward, N. M., Barros, C. S., Brand, A. H. ; 34 (1-2): 170?73

    View details for DOI 10.1002/gene.10146

    View details for PubMedID 12324976

  • A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Cell reports Zhang, J., Weinrich, J. A., Russ, J. B., Comer, J. D., Bommareddy, P. K., DiCasoli, R. J., Wright, C. V., Li, Y., van Roessel, P. J., Kaltschmidt, J. A. 2017; 21 (3): 666?78

    Abstract

    Spinal interneurons are critical modulators of motor circuit function. In the dorsal spinal cord, a set of interneurons called GABApre presynaptically inhibits proprioceptive sensory afferent terminals, thus negatively regulating sensory-motor signaling. Although deficits in presynaptic inhibition have been inferred in human motor diseases, including dystonia, it remains unclear whether GABApre circuit components are altered in these conditions. Here, we use developmental timing to show that GABApre neurons are a late Ptf1a-expressing subclass and localize to the intermediate spinal cord. Using a microarray screen to identify genes expressed in this intermediate population, we find the kelch-like family member Klhl14, implicated in dystonia through its direct binding with torsion-dystonia-related protein Tor1a. Furthermore, in Tor1a mutant mice in which Klhl14 and Tor1a binding is disrupted, formation of GABApre sensory afferent synapses is impaired. Our findings suggest a potential contribution of GABApre neurons to the deficits in presynaptic inhibition observed in dystonia.

    View details for DOI 10.1016/j.celrep.2017.09.079

    View details for PubMedID 29045835

  • Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord NEURON Mende, M., Fletcher, E. V., Belluardo, J. L., Pierce, J. P., Bommareddy, P. K., Weinrich, J. A., Kabir, Z. D., Schierberl, K. C., Pagiazitis, J. G., Mendelsohn, A. I., Francesconi, A., Edwards, R. H., Milner, T. A., Rajadhyaksha, A. M., van Roessel, P. J., Mentis, G. Z., Kaltschmidt, J. A. 2016; 90 (6): 1189-1202

    Abstract

    Circuit function in the CNS relies on the balanced interplay of excitatory and inhibitory synaptic signaling. How neuronal activity influences synaptic differentiation to maintain such balance remains unclear. In the mouse spinal cord, a population of GABAergic interneurons, GABApre, forms synapses with the terminals of proprioceptive sensory neurons and controls information transfer at sensory-motor connections through presynaptic inhibition. We show that reducing sensory glutamate release results in decreased expression of GABA-synthesizing enzymes GAD65 and GAD67 in GABApre terminals and decreased presynaptic inhibition. Glutamate directs GAD67 expression via the metabotropic glutamate receptor mGluR1? on GABApre terminals and regulates GAD65 expression via autocrine influence on sensory terminal BDNF. We demonstrate that dual retrograde signals from sensory terminals operate hierarchically to direct the molecular differentiation of GABApre terminals and the efficacy of presynaptic inhibition. These retrograde signals comprise a feedback mechanism by which excitatory sensory activity drives GABAergic inhibition to maintain circuit homeostasis.

    View details for DOI 10.1016/j.neuron.2016.05.008

    View details for Web of Science ID 000378527600009

    View details for PubMedID 27263971

    View details for PubMedCentralID PMC4912012

  • Care within a Veterans Hospital - Earlier detection of colon cancer SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES van Roessel, P., Rouse, R. V., Wren, S. M. 2007; 21 (8): 1434-1440

    Abstract

    In 1998 the Veterans Administration mandated an externally monitored targeted colon cancer screening rate that was expected to result in earlier cancer detection and improved patient survival. The effectiveness of the protocol was evaluated in a retrospective case series at a tertiary care Veterans Administration Hospital that included all patients with the diagnosis of colon cancer between 1991 and 2003.Tumor stage, tumor location, and patient survival data were recorded and compared to National Cancer Data Base (NCDB) benchmarks.The study facility had a greater percentage of early cancers and fewer later stage cancers than the NCDB benchmark. Overall survival was better for the VA cohort compared to NCDB (all-cause 5-year survival: VA, 0.72; NCDB, 0.47. p < or = .001).The VA facility had a significantly greater percentage of early cancers and fewer stage III or IV cancers compared to a national benchmark and significantly improved survival compared to the national benchmark.

    View details for DOI 10.1007/s00464-006-9184-6

    View details for Web of Science ID 000248737700035

    View details for PubMedID 17294311

  • Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell van Roessel, P., Elliott, D. A., Robinson, I. M., Prokop, A., Brand, A. H. 2004; 119 (5): 707?18

    Abstract

    Neuronal plasticity relies on tightly regulated control of protein levels at synapses. One mechanism to control protein abundance is the ubiquitin-proteasome degradation system. Recent studies have implicated ubiquitin-mediated protein degradation in synaptic development, function, and plasticity, but little is known about the regulatory mechanisms controlling ubiquitylation in neurons. In contrast, ubiquitylation has long been studied as a central regulator of the eukaryotic cell cycle. A critical mediator of cell-cycle transitions, the anaphase-promoting complex/cyclosome (APC/C), is an E3 ubiquitin ligase. Although the APC/C has been detected in several differentiated cell types, a functional role for the complex in postmitotic cells has been elusive. We describe a novel postmitotic role for the APC/C at Drosophila neuromuscular synapses: independent regulation of synaptic growth and synaptic transmission. In neurons, the APC/C controls synaptic size via a downstream effector Liprin-alpha; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor.

    View details for DOI 10.1016/j.cell.2004.11.028

    View details for PubMedID 15550251

  • Spreading silence with Sid. Genome biology van Roessel, P., Brand, A. H. 2004; 5 (2): 208

    Abstract

    RNA interference (RNAi) has been shown to spread from cell to cell in plants and in Caenorhabditis elegans, but it does not spread in other organisms, such as Drosophila. A recent report demonstrates that a membrane channel, encoded by the gene sid-1, is responsible for the spreading of RNAi between cells.

    View details for DOI 10.1186/gb-2004-5-2-208

    View details for PubMedID 14759251

    View details for PubMedCentralID PMC395742

  • Region-specific apoptosis limits neural stem cell proliferation. Neuron Brand, A. H., van Roessel, P. J. 2003; 37 (2): 185?87

    Abstract

    Regulation of stem cell division is of particular interest, both for studies of development and for stem cell therapeutics. In this issue of Neuron, Bello et al. show that the number of divisions of Drosophila neural stem cells is limited, in a region-specific manner, by regulated apoptosis in response to a pulse of expression of the Hox gene abdominal-A (abdA).

    View details for PubMedID 12546811

  • Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins. Nature cell biology van Roessel, P., Brand, A. H. 2002; 4 (1): E15?20

    Abstract

    Since its introduction into heterologous organisms as a marker of gene expression, the green fluorescent protein (GFP) has led a dramatic revolution in cell, developmental and neurobiology. By allowing breathtaking visualization of fluorescent fusion proteins as they move within and between cells, GFP has fundamentally transformed the spatial analysis of protein function. Now, new GFP technologies allow far more than simple observations of fusion protein localization. The growing family of fluorescent protein variants is enabling more sophisticated studies of protein function and illuminating wide-ranging processes from gene expression to second-messenger cascades and intercellular signalling. Together with advances in microscopy, new GFP-based experimental approaches are forging a second GFP revolution.

    View details for DOI 10.1038/ncb0102-e15

    View details for PubMedID 11780139

  • Activity of long-wavelength cones under scotopic conditions in the cyprinid fish Danio aequipinnatus. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology van Roessel, P., Palacios, A. G., Goldsmith, T. H. 1997; 181 (5): 493?500

    Abstract

    In carp (Cyprinus) and goldfish (Carassius), long-wavelength cones are reported to be active under scotopic conditions. Using the electroretinogram (ERG), we tested another cyprinid fish, Danio aequipinnatus, which contains A1-based visual pigments and for which we had previously measured the spectral sensitivities of individual cones. Dark adaptation curves show a rod/cone break at about 45 min. When thoroughly dark-adapted, the spectral sensitivity function is broader than can be accounted for by self-screening of rhodopsin, but it can be modeled by an additive combination of rods and the 560-nm cones. Dim, red background light causes adaptation of rods and a broadening of the spectral sensitivity function, which can be simulated by increasing the proportion of cones in the model. Brighter red backgrounds adapt the 560-nm cones. Because of the effect of red adapting lights, the ERG evidence for the participation of long-wavelength cones close to visual threshold appears to be different in Danio than in the goldfish Carassius.

    View details for PubMedID 9373956

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