Bio

Clinical Focus


  • Internal Medicine

Academic Appointments


Professional Education


  • Residency: University of California San Diego School of Medicine Registrar (2013) CA
  • Board Certification: American Board of Internal Medicine, Internal Medicine (2013)
  • Medical Education: University of California at San Francisco School of Medicine (2010) CA

Research & Scholarship

Clinical Trials


  • Virtual Reality Technology Versus Standard Technology During Pediatric Oral Food Challenge Not Recruiting

    The purpose of this study is to determine if non-invasive distracting devices (Virtual Reality headset) are more effective than the standard of care of utilizing existing technologies that are currently more common in food allergy research treatment and clinics (i.e. television and patients' personal electronic devices) for decreasing levels anxiety and fear in pediatric patients undergoing oral food challenge (OFC) and their caregivers.

    Stanford is currently not accepting patients for this trial. For more information, please contact Study Team, 650-521-7237.

    View full details

Publications

All Publications


  • Perceived Burden of Treatment and Quality of Life in Long-Term Follow Up after Oral Immunotherapy in Food Allergic Patients Collins, W., Raeber, O., Tupa, D., Cao, S., Nadeau, K., Sindher, S., Chinthrajah, S. MOSBY-ELSEVIER. 2020: AB147
  • NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY White, M. P., Theodoris, C. V., Liu, L., Collins, W. J., Blue, K. W., Lee, J., Meng, X., Robbins, R. C., Ivey, K. N., Srivastava, D. 2015; 84: 13?23

    Abstract

    Valvular and vascular calcification are common causes of cardiovascular morbidity and mortality. Developing effective treatments requires understanding the molecular underpinnings of these processes. Shear stress is thought to play a role in inhibiting calcification. Furthermore, NOTCH1 regulates vascular and valvular endothelium, and human mutations in NOTCH1 can cause calcific aortic valve disease. Here, we determined the genome-wide impact of altering shear stress and NOTCH signaling on human aortic valve endothelium. mRNA-sequencing of primary human aortic valve endothelial cells (HAVECs) with or without knockdown of NOTCH1, in the presence or absence of shear stress, revealed NOTCH1-dependency of the atherosclerosis-related gene connexin 40 (GJA5), and numerous repressors of endochondral ossification. Among these, matrix gla protein (MGP) is highly expressed in aortic valve and vasculature, and inhibits soft tissue calcification by sequestering bone morphogenetic proteins (BMPs). Altering NOTCH1 levels affected MGP mRNA and protein in HAVECs. Furthermore, shear stress activated NOTCH signaling and MGP in a NOTCH1-dependent manner. NOTCH1 positively regulated endothelial MGP in vivo through specific binding motifs upstream of MGP. Our studies suggest that shear stress activates NOTCH1 in primary human aortic valve endothelial cells leading to downregulation of osteoblast-like gene networks that play a role in tissue calcification.

    View details for PubMedID 25871831

    View details for PubMedCentralID PMC4468000

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