Current Research and Scholarly Interests
I'm interested in both basic and translational cardiovascular biology, regenerative medicine and genomics. Much of my work merges next generation sequencing (NGS) with iPS cell models to find and characterize primate-specific elements within the noncoding genome (lncRNAs, transposable elements, enhancers). Some of these primate elements appear to regulate heart development, disease and even evolution, and with the enormous growth in pluripotent cell technologies their functions can now be experimentally studied. In translational work, I'm developing custom targeted NGS assays for identifying the DNA mutations that underlie cardiomyopathies and other heart diseases.