All Publications

  • The Climate-Smart Emergency Department: A Primer. Annals of emergency medicine Linstadt, H., Collins, A., Slutzman, J. E., Kimball, E., Lemery, J., Sorensen, C., Winstead-Derlega, C., Evans, K., Auerbach, P. S. 2020


    Climate change and environmental pollution from health care present urgent, complex challenges. The US health care sector produces 10% of total US greenhouse gas emissions, which have negative influences on human and environmental health. The emergency department (ED) is an important place in the hospital to become more environmentally responsible and "climate smart," a term referring to the combination of low-carbon and resilient health care strategies. Our intent is to educate and motivate emergency providers to action by providing a guide to sustainable health care and an approach to creating a climate-smart ED.

    View details for DOI 10.1016/j.annemergmed.2019.11.003

    View details for PubMedID 31983497

  • Day of Ascent Dosing of Acetazolamide for Prevention of Acute Mountain Sickness. High altitude medicine & biology Lipman, G. S., Jurkiewicz, C., Winstead-Derlega, C., Navlyt, A., Burns, P., Walker, A., Phillips, C., Reilly, A., Burnier, A., Romero, J., Warner, K., Hackett, P. 2019


    Lipman, Grant S., Carrie Jurkiewicz, Christopher Winstead-Derlega, Andrew Navlyt, Patrick Burns, Anne Walker, Caleb Phillips, Aaron Reilly, Andre Burnier, Joseph Romero, Keiran Warner, and Peter Hackett. Day of ascent dosing of acetazolamide for prevention of acute mountain sickness. High Alt Med Biol 00:000-000, 2019. Background: Acetazolamide is the most common medication used for prevention of acute mountain sickness (AMS), usually administered the day or night before ascent. The objective of this study was to evaluate the efficacy of day of ascent dosing of acetazolamide for AMS prevention. Methods: Double-blind, randomized, controlled noninferiority trial of acetazolamide 125?mg twice daily beginning either the night before or the morning of ascent. Healthy low altitude adults ascended from 1240?m (4100 ft) to 3810?m (12,570 ft) during summer 2018 on White Mountain, California. Primary outcome was incidence of AMS with the two different dosing patterns, assessed by the 1993 Lake Louise Questionnaire (LLQ) of ?3 with headache and a minimum of 1 for other symptom. Results: One hundred four participants completed the study, with 54 (52%) randomized to night before acetazolamide and 50 (48%) to day of ascent dosing, without differences in baseline characteristics. There was 9% greater incidence of AMS in the day of ascent acetazolamide group (48.0% vs. 39%, 95% confidence interval [CI] -11.8 to 30, p?=?0.46, number needed to treat [NNT]?=?5.6 vs. 3.7), with the CI just surpassing the predetermined 26% noninferiority margin. There was a lower incidence of severe AMS (1993 LLQ >5) in the day of ascent group (n?=?5, 10%, NNT?=?2.3) compared with night before dosing (n?=?12, 22%, NNT?=?3.1) (95% CI -28 to 3.6), and lower average symptom severity in the day of ascent group (3 vs. 3.5, 95% CI -0.5 to 1.4). Conclusions: Day of ascent acetazolamide demonstrated higher rates of AMS compared with traditional dosing by a small margin. With similar rates of severe AMS and overall symptom severity, the potential for improved convenience and compliance may support day of ascent use.

    View details for DOI 10.1089/ham.2019.0007

    View details for PubMedID 31259608

  • Pre-earthquake non-epidemic Vibrio cholerae in Haiti JOURNAL OF INFECTION IN DEVELOPING COUNTRIES Liu, J., Winstead-Derlega, C., Houpt, E., Heidkamp, R., Pape, J., Dillingham, R. 2014; 8 (1): 120-122


    To our knowledge, there was no record of Vibrio cholerae in Haiti until the 2010 post earthquake outbreak.This study describes the analysis of 301 stool samples from 117 infants in Port-au-Prince, Haiti, who participated in a pediatric nutrition study between July 2008 and October 2009.Nine samples were identified positive with both SYBR Green and Taqman-MGB probe based molecular assays targeting V. cholerae hlyA and toxR, respectively (Ct = 33-40), but none were O1 or O139.Our results from multiple molecular assays demonstrate the presence of non-O1/O139 V. cholerae DNA in stools collected from nine asymptomatic Haitian infants two years prior to the 2010 earthquake.

    View details for DOI 10.3855/jidc.4524

    View details for Web of Science ID 000339853700017

    View details for PubMedID 24423722

  • Development of a personalized bidirectional text messaging tool for HIV adherence assessment and intervention among substance abusers JOURNAL OF SUBSTANCE ABUSE TREATMENT Ingersoll, K., Dillingham, R., Reynolds, G., Hettema, J., Freeman, J., Hosseinbor, S., Winstead-Derlega, C. 2014; 46 (1): 66-73


    We describe the development of a two-way text messaging intervention tool for substance users who are non-adherent with HIV medications, and examine message flow data for feasibility and acceptability. The assessment and intervention tool, TxText, is fully automated, sending participants mood, substance use, and medication adherence queries by text message. Participants respond, the tool recognizes the category of response, and sends the personalized intervention message that participants designed in return. In 10months, the tool sent 16,547 messages (half initial, half follow-up) to 31 participants assigned to the TxText condition, who sent 6711 messages in response to the initial messages. Response rates to substance use (n=2370), medication (n=2918) and mood (n=4639) queries were 67, 69, and 64%, respectively. Responses indicating medication adherence, abstinence from substances, and good moods were more common than negative responses. The TxText tool can send messages daily over a 3month period, receive responses, and decode them to deliver personalized affirming or intervention messages. While we await the outcomes of a pilot randomized trial, the process analysis shows that TxText is acceptable and feasible for substance abusers with HIV, and may serve as a complement to HIV medical care.

    View details for DOI 10.1016/jjsat.2013.08.002

    View details for Web of Science ID 000326908500010

    View details for PubMedID 24029625

  • A Pilot Study of Delivering Peer Health Messages in an HIV Clinic via Mobile Media TELEMEDICINE AND E-HEALTH Winstead-Derlega, C., Rafaly, M., Delgado, S., Freeman, J., Cutitta, K., Miles, T., Ingersoll, K., Dillingham, R. 2012; 18 (6): 464-469


    This pilot study tested the feasibility and impact of using mobile media devices to present peer health messages to human immunodeficiency virus (HIV)-positive patients.A convenience sample of 30 adult patients from an outpatient HIV clinic serving a mostly rural catchment area in central Virginia volunteered for the study. Participants viewed short videos of people discussing HIV health topics on an Apple (Cupertino, CA) iPod® touch® mobile device. Pre- and post-intervention surveys assessed attitudes related to engagement in care and disease disclosure.Participants found delivery of health information by the mobile device acceptable in a clinic setting. They used the technology without difficulty. Participants reported satisfaction with and future interest in viewing such videos after using the mobile devices. The majority of participants used the device to access more videos than requested, and many reported the videos "hit home." There were no significant changes in participant perceptions about engagement in care or HIV disclosure after the intervention.This pilot study demonstrates the feasibility and acceptability of using mobile media technology to deliver peer health messages. Future research should explore how to best use mobile media to improve engagement in care and reduce perceptions of stigma.

    View details for DOI 10.1089/tmj.2011.0236

    View details for Web of Science ID 000306595000011

    View details for PubMedID 22732025

  • Intimate Partner Violence: A Predictor of Worse HIV Outcomes and Engagement in Care AIDS PATIENT CARE AND STDS Schafer, K. R., Brant, J., Gupta, S., Thorpe, J., Winstead-Derlega, C., Pinkerton, R., Laughon, K., Ingersoll, K., Dillingham, R. 2012; 26 (6): 356-365


    For HIV-infected patients, experiencing multiple traumas is associated with AIDS-related and all-cause mortality, increased opportunistic infections, progression to AIDS, and decreased adherence to therapy. The impact of intimate partner violence (IPV) on adherence and HIV outcomes is unknown. HIV-infected patients recruited from a public HIV clinic participated in this observational cohort study (n=251). Participants completed interviews evaluating IPV and covariates. CD4 count <200 (CD4<200), detectable HIV viral load (VL), and engagement in care ("no show rate" [NSR]) were the outcomes of interest. Medication adherence was not measured. Univariate and multivariate regression analyses were performed with covariates included if p<0.3 in the univariate phase. Seventy-four percent of the participants were male, 55% Caucasian, and 52.2% self-identified as "men who have sex with men." IPV prevalence was 33.1% with no difference by gender or sexual orientation. In univariate analysis, IPV exposure predicted having a CD4<200 (p=0.005) and a detectable VL (p=0.04) but trended toward significance with a high NSR (p=0.077). Being threatened by a partner was associated with a CD4<200 (p=0.005), a detectable VL (p=0.011), and high NSR (p=0.019) in univariate analysis. In multivariate analysis, IPV predicted having a CD4<200 (p=0.005) and detectable VL (p=0.035). Being threatened by a partner predicted having a CD4<200 (p=0.020), a detectable VL (p=0.007), and a high NSR (p=0.020). Our results suggest IPV impacts biologic outcomes and engagement in care for HIV-infected patients. IPV alone predicts worse biologic outcomes, whereas the specific experience of being threatened by a partner was associated with all three outcomes in univariate and multivariate analyses.

    View details for DOI 10.1089/apc.2011.0409

    View details for Web of Science ID 000305160100007

    View details for PubMedID 22612519

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