School of Medicine
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Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly Interests My research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Christopher K. Zarins
Walter Clifford Chidester and Elsa Rooney Chidester Professor of Surgery, Emeritus
Current Research and Scholarly Interests Hemodynamic factors in atherosclerosis, pathogenesis of, aortic aneurysms, carotid plaque localization and complication, anastomotic intimal hyperplasia, vascular biology of artery wall, computational fluid dynamics as applied to blood flow and vascular disease.
James L. Zehnder, M.D.
Professor of Pathology (Research) and of Medicine (Hematology) at the Stanford University Medical Center
Current Research and Scholarly Interests Our laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in molecular pathology, diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
Bio Dr. Zein received her dual bachelor?s degrees in Anthropology and Physiological Science at UCLA and worked initially as a healthcare consultant, developing programs that improve healthcare access for vulnerable populations. She returned to school to pursue a Masters in Public Health at Johns Hopkins University, where she further developed her interests in the intersection of medicine and broader social-cultural themes, particularly the impact on mental health. Her research foci were disaster response interventions for physical and mental health and the impact of the built environment on public health. During her masters, she worked with the International Rescue Committee in Baltimore to help address the acculturation and psychological stress the Baltimore refugee population faced in resettlement.
In 2010, Dr. Zein began her medical training at McGill University in Montreal, Canada. During medical school she continue to pursue interests in global and cultural health. She represented McGill nationally as the Global Health Advocate in the Canadian Federation of Medical Students, and focused on national and local clinical projects to support refugee and asylum seeker access to medical and mental health treatment. She was awarded the Mona Bronfman Sheckman Prize in Psychiatry for her work. During her psychiatry residency training at New York University (NYU), Dr. Zein continued pursuing her interest in global mental health, working as a group leader for refugees/asylum seekers in the Bellevue Survivors of Torture program, and the Association for Culture and Psychiatry. She also became interested in Integrated Behavioral Health, particularly the University of Washington's Ambulatory Integration of the Medical and Social (AIMs) model, or Collaborative Care Model. She founded the Integrated Behavioral Health resident working group and designed a two-year resident training program in the Collaborative Care Model as well as pioneered other electives in HIV psychiatry and psych-oncology. She completed training in the AIMs model and also was part of an intensive collaborative pilot with the AIMs center to a complete a quality-improvement (QI) project in the Bellevue Hospital primary care site. As part of the two-year resident training program she developed a Collaborative Care model in one of NYU Langone-Brooklyn's FQHC sites. In her last two years of residency she was an APA Leadership Fellow, and served on the APA Consult-Liaison Psychiatry Committee. She worked on a Decisional Capacity Guidelines paper with other committee members, and presented on Consult Liaison educational opportunities and Integrated Behavioral Health Models at the APA conference. She completed residency as a chief resident and won awards for Excellence in Resident Teaching as well as for humanism and clinical excellence in the Comprehensive Psychiatric Emergency Program
Dr. Zein completed her Consult Liaison Fellowship at Stanford and has remained as clinical faculty. She is currently serving as an attending psychiatrist on the General, Intensive Care, and ED-Psychiatry consult services as well as developing an Integrated Behavioral Health model for the Stanford Primary Care Clinic serving Cisco employees and their families. She is currently working on expanding Integrated Behavioral health to other Stanford Primary Care Clinics, has worked with Stanford's digital health team to start and expand psychiatry e-consults for primary care. She also has taken on a new role as the Behavioral Health Director for Cisco, applying principles of organizational psychiatry and public health to assess company behavioral health strategy
Associate Professor of Radiology (Neuroimaging and Neurointervention) at the Stanford University Medical Center
Bio Dr. Michael Zeineh received a B.S. in Biology at Caltech in 1995 and obtained his M.D.-Ph.D. from UCLA in 2003. After internship also at UCLA, he went on to radiology residency and neuroradiology fellowship both at Stanford. He has been faculty in Stanford Neuroradiology since 2010. Combining clinical acumen in neuroradiology with advanced MRI acquisition and image processing as well as histologic validation, Dr. Zeineh hopes to advance the care of patients with neurodegenerative disorders.
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly Interests Dr. Zeitzer is a circadian physiologist specializing in the understanding of the impact of light on circadian rhythms and other aspects of non-image forming light perception.
He examines the manner in which humans respond to light and ways to manipulate this responsiveness, with direct application to jet lag, shift work, and altered sleep timing in teens. Dr. Zeitzer has also pioneered the use of actigraphy in the determination of epiphenomenal markers of psychiatric disorders.
Bing Melody Zhang
Clinical Assistant Professor, Pathology
Current Research and Scholarly Interests My main research interests lie in the following areas:
1) Using genetic/genomic approaches to study the genotype-phenotype correlation of inherited non-malignant hematologic disorders, especially platelet disorders.
2) Development and application of molecular assays for clinical testing to support hematopoietic stem cell transplantation and solid organ transplantation.
3) NGS-based TCR/Ig clonality/MRD diagnostic testing.
4) HLA-related disease association and pharmacogenetic testing.
Fanglin Zhang, MD
Clinical Assistant Professor, Neurology & Neurological Sciences
Bio Dr. Zhang is a board-certified neurologist, in both neurology and clinical neurophysiology. She serves as a clinical assistant professor in the Department of Neurology at Stanford University School of Medicine.
Dr. Zhang excels at the diagnosis and treatment of complicated neurological diseases and her clinical interests are broad, including intractable epilepsy and stroke urgent care.
With each patient, Dr. Zhang forms a strong alliance focused on overcoming neurological disease and improving quality of life. She practices a patient-centered and evidence-based medicine.
Dr. Zhang and her colleagues led the Stanford Health Care - ValleyCare Neurology & Neurological Sciences Department response to the COVID-19 pandemic. Efforts focused on the safety of patients and staff and minimizing disruptions to urgent and essential clinical services, such as stroke care.
Her COVID-19 response efforts also focused on fulfilling Stanford Health Care?s commitment to professional education and training. She enjoys training future neurologists. She has worked to ensure that Stanford Health Care medical students and residents to maintain momentum on their journey to becoming the neurology specialists of tomorrow.
In addition to delivering clinical care for a wide range of neurological conditions, Dr. Zhang enjoys conducting cutting-edge clinical research. Her work has been published in numerous peer-reviewed journals, such as Neurological Sciences, Annals of Clinical and Translational Neurology, Neuroimage, Glia, Immunology, the Journal of Psychiatric Practice, Journal of Neuroimmunology, etc. Her current research interest includes clinical trials and a large cohort study of the impact of seizures on stroke outcomes.
Among her many honors, Dr. Zhang has won a grant award from the National Multiple Sclerosis Society. Dr. Zhang shows a great enthusiasm in public welfare. She has earned recognition for volunteering her time and expertise at family health centers, hospitals, and schools.
Clinical Assistant Professor, Neurology & Neurological Sciences
Bio Dr. Niushen Zhang specializes in the treatment of headache and facial pain. Dr. Zhang has a special interest in complementary and alternative medicine for the treatment of headaches and facial pain. She is the Director of the Headache Fellowship Program at Stanford.
Professor (Research) of Neurosurgery
Current Research and Scholarly Interests My lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patients chance for recovery.
Bio Dr. Zhu is a general cardiologist with specialized clinical and research training in cardio-oncology and cardio-immunology. She focuses on the cardiovascular care of patients undergoing therapies for cancer, with a particular focus on the effects of immunotherapies on the heart. She completed clinical cardiology fellowship and internal medicine residency training at Stanford University School of Medicine. During her post-doctoral training, Dr. Zhu?s research focuses on myocarditis, cardiac inflammation, and the effects of cancer therapeutics on the cardiovascular system. Her current research employs clinical data, bio-banked samples, and animal models to study T-cell toxicities in the heart. Dr. Zhu's clinic sees cardio-oncology and cardio-immunology patients and focuses on devising new methods for minimizing cardiovascular complications in the cancer patient population.
Maisa Ziadni, PhD
Instructor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly Interests Development and testing of novel interventions for chronic pain.
Understanding mechanisms of treatment among patients with chronic with pain.
Understanding predictors of opioid use among patients with chronic pain.
Clinical Assistant Professor, Medicine - Gastroenterology & Hepatology
Bio I am initially a Pittsburgh, PA native, but have been at Stanford University since 2012 for residency, fellowship, and now as faculty. It is exciting to be affiliated with one of the most dynamic and innovative medical institutions worldwide.
My clinical and research interests focus on functional, motility, and esophageal disorders of the gastrointestinal tract. Outside of this sub-sub specialization, a significant portion of my practice is also devoted to the care of a broad range of ?general gastroenterology? concerns.
Functional, motility, esophageal, and general gastroenterology disorders are very common, and can cause significant disability. Some examples include irritable bowel syndrome, functional dyspepsia, gastroparesis, chronic nausea, chronic constipation, achalasia, and gastroesophageal reflux disease.
Despite the common nature of these disorders, many are not well understood, leading to frustration among both patients and clinicians alike. Furthermore, there is an incorrect stigma associated with some of these disorders that ?it is all in your head.? On the opposite side of the spectrum, there is sometimes an incorrect assumption that we will be able to pinpoint an exact underlying cause in all cases, but this is not possible with current technology. We aim to bridge this gap using the latest diagnostic testing and treatment paradigms, as well as a healing hand. Additionally, our group is actively engaged in multiple research projects and studies to drive the future of the field.
Though I am early in my career, I am hoping that by the end the field will look nothing like it does today. I am hopeful, and I believe that we can revolutionize the field to better characterize gastrointestinal disorders, and come up with highly effective targeted treatments.
Clinical Instructor, Otolaryngology - Head & Neck Surgery Divisions
Bio Dr. Zolkind is originally from New York. He completed an otolaryngology residency training at Washington University in Saint Louis. He is currently the Head and Neck Surgery/Microvascular Fellow at Stanford University. His clinical interests include cancers of the upper aerodigestive tract, thyroid and salivary glands as well as complex reconstruction of the head and neck. His research interests include immunotherapy approaches for head and neck cancer. Outside the hospital he enjoys spending time with his family and friends, biking, running and hiking
Professor of Medicine (Infectious Diseases) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly Interests Dr. Zolopas research applies a variety of clinical epidemiologic methods in an effort to optimize antiretroviral therapy and understand the impact of drug resistance on response to ARV. Areas of focus include the clinical application of resistance testing in optimizing antiretroviral therapy, clinical cohorts, trials of antiretroviral therapies and population-based epidemiologic evaluation of HIV resistance and efficacy of ARV therapy. More recently studies focused on premature aging in HIV.
Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering
Current Research and Scholarly Interests My group works on both foundations of statistical machine learning and applications in biomedicine and healthcare. We develop new technologies that make ML more accountable to humans, more reliable/robust and reveals core scientific insights.
We want our ML to be impactful and beneficial, and as such, we are deeply motivated by transformative applications in biotech and health. We collaborate with and advise many academic and industry groups.
J. Bradley Zuchero
Assistant Professor of Neurosurgery
Current Research and Scholarly Interests Glia are a frontier of neuroscience, and overwhelming evidence from the last decade shows that they are essential regulators of all aspects of the nervous system. The Zuchero Lab aims to uncover how glial cells regulate neural development and how their dysfunction contributes to diseases like multiple sclerosis (MS) and in injuries like stroke.
Although glia represent more than half of the cells in the human brain, fundamental questions remain to be answered. How do glia develop their highly specialized morphologies and interact with neurons to powerfully control form and function of the nervous system? How is this disrupted in neurodegenerative diseases and after injury? By bringing cutting-edge cell biology techniques to the study of glia, we aim to uncover how glia help sculpt and regulate the nervous system and test their potential as novel, untapped therapeutic targets for disease and injury.
We are particularly interested in myelin, the insulating sheath around neuronal axons that is lost in diseases like MS. How do oligodendrocytes- the glial cell that produces myelin in the central nervous system- form and remodel myelin, and why do they fail to regenerate myelin in disease? Our current projects aim to use cell biology and neuroscience approaches to answer these fundamental questions. Ultimately we hope our work will lead to much-needed therapies to promote remyelination in patients.
Clinical Associate Professor, Radiology - Pediatric Radiology
Bio Dr. Zucker is a board-certified pediatric and cardiovascular radiologist with a special interest in CT and MRI for congenital heart disease.
Assistant Professor of Medicine (General Medical Disciplines)
Current Research and Scholarly Interests - Health care delivery models for patients with complex medical, social and behavioral needs.
- Interventions that address social determinants of health
- Effective communication and relationship-building in the clinical context
- Patient-facing technology (e.g., video-based care, eHealth technology) to facilitate access to health care
Assistant Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests My goal is to translate research into real-world action and decision-making so that my work can impact patients and the institutions in which they receive care. With a research focus on healthcare cost and quality of care, I approach neurosurgery in a unique way?one that applies business operations, economics, and healthcare delivery principles to our field. I have pursued formal LEAN business training, and believe in the importance of working together with other departments and administrators, as well as physicians and surgeons on the hospital and national level, to effect change. During my residency, I developed and led a multi-departmental prospective study at UCSF called OR SCORE (OR Surgical Cost Reduction Project) that brought together surgeons from the neurosurgery, orthopedics and ENT departments with nurses and administrators. OR SCORE successfully reduced surgical supply costs by nearly one million dollars in its first year by providing >60 surgeons with price transparency scorecards. This work led to a first-author publication in JAMA Surgery, but more importantly, set the foundation for further quality improvement and cost reduction efforts across the UCSF hospital system.
A volunteer neurosurgical mission trip to Guadalajara, Mexico, where limited resources create an OR environment that is strikingly more frugal than the U.S., inspired me to lead another project aimed at quantifying and reducing operating room waste at UCSF. I have also conducted research looking at the safety and outcomes of overlapping surgery, as well as several projects to define the factors underlying variation in cost for neurosurgical care using UCSF?s hospital data and national databases like the National Inpatient Sample, Vizient (formerly known as University Health Consortium), and Medicare.
As a clinical fellow at Johns Hopkins, I continued and expanded these research efforts. I designed and implemented an Enhanced Recovery after Surgery (ERAS) protocol at the Johns Hopkins Bayview hospital. This protocol standardized care for our spine patients, emphasizing pre-operative rehabilitation, psychiatric and nutritional assessments, and smoking cessation, as well as intra- and post-operative multi-modal pain therapy, early mobilization, and standardized antibiotic and bowel regimens. I also collaborated with engineers in the Johns Hopkins Carnegie Center for Surgical Innovation to develop better algorithms for intra-operative CT imaging, and provided assistance with operations to a basic science study looking at the role of cerebrospinal fluid drainage and duraplasty in a porcine model of spinal cord injury.
At Stanford, I am building a research group focused on: (1) perfecting paradigms for delivery of high-end technology in spinal care, including robotics and navigation, (2) implementing cost and quality strategies in large healthcare systems, and (3) computational analysis of big-data to effect real-time risk stratification and decision making in spine surgery. I'm excited to collaborate with my peers across surgical and medical departments, as well as business and engineering colleagues.