School of Medicine
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Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly Interests My research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Christopher K. Zarins
Walter Clifford Chidester and Elsa Rooney Chidester Professor of Surgery, Emeritus
Current Research and Scholarly Interests Hemodynamic factors in atherosclerosis, pathogenesis of, aortic aneurysms, carotid plaque localization and complication, anastomotic intimal hyperplasia, vascular biology of artery wall, computational fluid dynamics as applied to blood flow and vascular disease.
James L. Zehnder, M.D.
Professor of Pathology (Research) and of Medicine (Hematology) at the Stanford University Medical Center
Current Research and Scholarly Interests Our laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in molecular pathology, diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
Bio Dr. Zein received her dual bachelor?s degrees in Anthropology and Physiological Science at UCLA and worked initially as a healthcare consultant, developing programs that improve healthcare access for vulnerable populations. She returned to school to pursue a Masters in Public Health at Johns Hopkins University, where she further developed her interests in the intersection of medicine and broader social-cultural themes, particularly the impact on mental health. Her research foci were disaster response interventions for physical and mental health and the impact of the built environment on public health. During her masters, she worked with the International Rescue Committee in Baltimore to help address the acculturation and psychological stress the Baltimore refugee population faced in resettlement.
In 2010, Dr. Zein began her medical training at McGill University in Montreal, Canada. During medical school she continue to pursue interests in global and cultural health. She represented McGill nationally as the Global Health Advocate in the Canadian Federation of Medical Students, and focused on national and local clinical projects to support refugee and asylum seeker access to medical and mental health treatment. She was awarded the Mona Bronfman Sheckman Prize in Psychiatry for her work. During her psychiatry residency training at New York University (NYU), Dr. Zein continued pursuing her interest in global mental health, working as a group leader for refugees/asylum seekers in the Bellevue Survivors of Torture program, and the Association for Culture and Psychiatry. She also became interested in Integrated Behavioral Health, particularly the University of Washington's Ambulatory Integration of the Medical and Social (AIMs) model, or Collaborative Care Model. She founded the Integrated Behavioral Health resident working group and designed a two-year resident training program in the Collaborative Care Model as well as pioneered other electives in HIV psychiatry and psych-oncology. She completed training in the AIMs model and also was part of an intensive collaborative pilot with the AIMs center to a complete a quality-improvement (QI) project in the Bellevue Hospital primary care site. As part of the two-year resident training program she developed a Collaborative Care model in one of NYU Langone-Brooklyn's FQHC sites. In her last two years of residency she was an APA Leadership Fellow, and served on the APA Consult-Liaison Psychiatry Committee. She worked on a Decisional Capacity Guidelines paper with other committee members, and presented on Consult Liaison educational opportunities and Integrated Behavioral Health Models at the APA conference. She completed residency as a chief resident and won awards for Excellence in Resident Teaching as well as for humanism and clinical excellence in the Comprehensive Psychiatric Emergency Program
Dr. Zein completed her Consult Liaison Fellowship at Stanford and has remained as clinical faculty. She is currently serving as an attending psychiatrist on the General, Intensive Care, and ED-Psychiatry consult services as well as developing an Integrated Behavioral Health model for the Stanford Primary Care Clinic serving Cisco employees and their families. She is currently working on expanding Integrated Behavioral health to other Stanford Primary Care Clinics, has worked with Stanford's digital health team to start and expand psychiatry e-consults for primary care. She also has taken on a new role as the Behavioral Health Director for Cisco, applying principles of organizational psychiatry and public health to assess company behavioral health strategy
Associate Professor of Radiology (Neuroimaging and Neurointervention) at the Stanford University Medical Center
Bio Dr. Michael Zeineh received a B.S. in Biology at Caltech in 1995 and obtained his M.D.-Ph.D. from UCLA in 2003. After internship also at UCLA, he went on to radiology residency and neuroradiology fellowship both at Stanford. He has been faculty in Stanford Neuroradiology since 2010. Combining clinical acumen in neuroradiology with advanced MRI acquisition and image processing as well as histologic validation, Dr. Zeineh hopes to advance the care of patients with neurodegenerative disorders.
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly Interests Dr. Zeitzer is a circadian physiologist specializing in the understanding of the impact of light on circadian rhythms and other aspects of non-image forming light perception.
He examines the manner in which humans respond to light and ways to manipulate this responsiveness, with direct application to jet lag, shift work, and altered sleep timing in teens. Dr. Zeitzer has also pioneered the use of actigraphy in the determination of epiphenomenal markers of psychiatric disorders.
Bing Melody Zhang
Clinical Assistant Professor, Pathology
Current Research and Scholarly Interests My main research interests lie in the following areas:
1) Using genetic/genomic approaches to study the genotype-phenotype correlation of inherited non-malignant hematologic disorders, especially platelet disorders.
2) Development and application of molecular assays for clinical testing to support hematopoietic stem cell transplantation and solid organ transplantation.
3) NGS-based TCR/Ig clonality/MRD diagnostic testing.
4) HLA-related disease association and pharmacogenetic testing.