School of Medicine

Showing 21-25 of 25 Results

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  Suzanne Pfeffer

  Emma Pfeiffer Merner Professor in the Medical Sciences

  Current Research and Scholarly Interests The major focuses of our research is to understand the molecular basis of inherited Parkinson's Disease (PD) and to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in culture and specific regions of the brain.

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  Rajat Rohatgi

  Associate Professor of Biochemistry and of Medicine (Oncology)

  Current Research and Scholarly Interests the overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.

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  Julia Salzman

  Associate Professor of Biochemistry and of Biomedical Data Science

  Current Research and Scholarly Interests Circular RNA regulation and function; computational and experimental approaches

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  James Spudich

  Douglass M. and Nola Leishman Professor of Cardiovascular Disease

  Current Research and Scholarly Interests The general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.

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  Aaron F. Straight

  Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

  Current Research and Scholarly Interests We study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.