School of Medicine
Showing 1-18 of 18 Results
Laura C. Lazzeroni, Ph.D.
Professor (Research) of Psychiatry and Behavioral Sciences and of Biomedical Data Science
Current Research and Scholarly Interests Statistics/Data Science. I develop & apply models, methods & algorithms for complex data in medical science & biology. I am also interested in the interplay between fundamental statistical properties (e.g. variability, bias, p-values) & how scientists actually use & interpret data. My work in statistical genetics includes: the invention of Plaid bi-clustering for gene expression data; methods for twin, association, & family studies; multiple testing & estimation for high dimensional arrays.
Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Bio Dr. Anson Lee specializes in the surgical treatment of all heart diseases, including ischemic heart disease, structural heart disease, aortic disease, and arrhythmias. He has practiced cardiothoracic surgery at Stanford since 2015. Dr. Lee has a special interest in the surgical treatment of abnormal heart rhythms and minimally invasive techniques to treat heart disease.
David Lee, MD
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests 1. Novel treatments and devices for the treatment of valvular disease
2. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy
3. Novel approaches to coronary revascularization
4. Closure devices for atrial septal defects and patent foramen ovale
5. Novel treatments for hypertension
Jason T. Lee
Professor of Surgery (Vascular Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Lee is the Principal Investigator on several clinical trials examining therapeutic strategies for management of complex aortic aneurysm disease as well as aortic dissection.
Dr. Lee’s clinical interests include:
•Endovascular repair of abdominal/thoracic aneurysms and dissections
Fenestrated and Branch Repair of the thoracic, thoracoabdominal, and abdominal aneurysms
•Thoracic outlet syndrome
•Vascular disorders in high-performance athletes
Maureen Lyles D'Ambrogio Professor in the School of Medicine and Senior Associate Dean, Veteran Affairs
Current Research and Scholarly Interests Our long term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on thrombin, the key enzyme in the blood clotting cascade.Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders.
Associate Professor of Mechanical Engineering and, by courtesy, of Radiology (Radiological Sciences Laboratory)
Current Research and Scholarly Interests My lab's research involves the function, degeneration and repair of musculoskeletal soft tissues, with a focus on meniscal fibrocartilage and articular cartilage. We are particularly interested in the complex interactions between biophysical and biochemical cues in controlling cell behavior, the roles of these interactions in degenerative conditions such as osteoarthritis, and development of tissue engineered 3D model systems for studying physical influences on primary and progenitor cells.
Professor of Radiology (Molecular Imaging Program at Stanford/Nuclear Medicine) and, by courtesy, of Physics, of Electrical Engineering and of Bioengineering
Current Research and Scholarly Interests Molecular Imaging Instrumentation
Our research interests involve the development of novel instrumentation and software algorithms for in vivo imaging of cellular and molecular signatures of disease in humans and small laboratory animal subjects.
Jin Billy Li
Associate Professor of Genetics
Current Research and Scholarly Interests The Li Lab is primarily interested in RNA editing mediated by ADAR enzymes. We co-discovered that the major function of RNA editing is to label endogenous dsRNAs as "self" to avoid being recognized as "non-self" by MDA5, a host innate immune dsRNA sensor, leading us to pursue therapeutic applications in cancer, autoimmune diseases, and viral infection. The other major direction of the lab is to develop technologies to harness endogenous ADAR enzymes for site-specific transcriptome engineering.
David Liang, MD, PhD
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center, Emeritus
Bio Stanford researchers are creating a micro-device that physicians could guide through the body to help diagnose and treat clogged arteries and other diseases. Tethered to the outside world by a thin wire, a tiny machine creeps through blood vessels, searching out deadly plaques and obliterating them with a zap of a laser. While a laser will come later, for now David Liang, MD, PhD, is focusing on a tiny eye that could give physicians an unprecedented view into blood vessels.
Professor of Medicine (Cardiovascular Medicine)
Bio Dr. Liao is a Professor of Medicine and co-Director of Stanford Cardiac Amyloid Center. The major goal of her research program focuses on understanding the mechanisms that underlie the pathophysiology of heart failure and developing novel treatments to combat this process. Her laboratory has played an international leading role in the study of amyloid light chain (AL) cardiomyopathy, a rare and fatal form of cardiovascular disease. We have described the underlying pathophysiologic basis for amyloid cardiomyopathy and found that the circulating amyloidogenic light chain proteins that characterize this disease directly result in a specific cardiotoxic response. Consequently, our research work has redefined AL cardiomyopathy and has raised new treatment approaches. More recently, her research efforts have expanded to include transthyretin (ATTR) cardiac amyloidosis.
In line with her goal of revealing novel therapeutic strategies for patients with cardiovascular disease, our efforts have also focused on characterizing and harnessing endogenous cardiac regenerative mechanisms. Her laboratory initially demonstrated the therapeutic potential of exogenous primitive muscle cells delivered to the injured heart. This work was among the earliest milestones in the field and served as the basis for an international trial of cell-based therapy. Subsequently, Liao lab identified and characterized a population of cardiac progenitor cells and its relationship and dynamic activity following cardiac injury in the adult heart. Her laboratory aims to reveal the molecular mechanisms regulating the endogenous regenerative capacity of the heart and to harness such repair mechanisms for the treatment of cardiovascular disease. Dr. Liao has lectured extensively on both amyloid cardiomyopathy and stem cell biology, and have maintained a history of independent NIH funding in these areas for more than two decades.
Over the course of her academic career, she has taken the greatest pride in mentoring the next generation of scientists. Dr. Liao has had the privilege to supervise several dozen students, postdoctoral fellows, and junior faculty, many of whom have gone on to independent academic careers at the highest institutions. Her contribution to the advancement of scientific knowledge also includes lecturing at various university and academic institutions as well as at scores of conferences and symposia locally, nationally, and internationally.
Associate Professor of Medicine (Hematology) at the Stanford University Medical Center
Current Research and Scholarly Interests 1) Design of phase I/II trials for the treatment of Multiple Myeloma and Amyloidosis
2) Conduct of clinical trials to improve the treatment of patients with acute lymphoblastic leukemia (ALL)
3) Outcomes research using clinical databases for patients with Multiple Myeloma and Amyloidosis
4) Characterization of the molecular mechanism of MLL-induced acute leukemia
Assistant Professor of Developmental Biology (Stem Cell)
Current Research and Scholarly Interests We have developed a strategy to generate fairly pure populations of various human tissue progenitors in a dish from embryonic stem cells (ESCs). We have delineated the sequential lineage steps through which ESCs diversify into various tissues, and in so doing, developed methods to exclusively induce certain fates at the expense of others. The resultant pure populations of tissue progenitors are the fundamental building blocks for regenerative medicine.
Jonathan Z. Long
Assistant Professor of Pathology
Current Research and Scholarly Interests Our laboratory focuses on the circulating factors in blood plasma that are secreted by and act on peripheral metabolic tissues. We are especially interested in those that are dynamically modulated by physiologic energy stressors such as nutrient availability, physical activity, or environmental temperature. What are the identities of these molecules? What energy stressors do they respond to? Where are they made? What cell types or tissues do they act on? We use chemical biology and mass spectrometry-based technologies as discovery tools. We combine these tools with classical biochemical and genetic approaches in cell and animal models. Our goal is to uncover new endocrine pathways of organismal energy metabolism. Recent studies from our laboratory have identified a family of cold-regulated circulating lipids that stimulate mitochondrial respiration as well as an exercise-stimulated thermogenic polypeptide hormone. We suspect that many more remain to be discovered. We anticipate that our approach will uncover fundamental mechanisms that control mammalian energy homeostasis. In the long term, we hope to translate our discoveries into therapeutic opportunities that matter for metabolic and other age-associated chronic diseases.
Deane P. and Louise Mitchell Professor in the School of Medicine and Professor, by courtesy, of Materials Science and Engineering
Current Research and Scholarly Interests We have six main areas of current interest: 1) Cranial Suture Developmental Biology, 2) Distraction Osteogenesis, 3) Fibroblast heterogeneity and fibrosis repair, 4) Scarless Fetal Wound Healing, 5) Skeletal Stem Cells, 6) Novel Gene and Stem Cell Therapeutic Approaches.