School of Medicine


Showing 21-27 of 27 Results

  • David Drover

    David Drover

    Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center

    Current Research and Scholarly Interests Field of clinical pharmacology. This involves analysis of what the body does to a drug (pharmacokinetics) and how exactly a specific drug affects the body (pharmacodynamics). His research starts at the level of new drug development with detailed analysis of the pharmacokinetics and pharmacodynamics of a medication.

  • Maurice L. Druzin

    Maurice L. Druzin

    Professor of Obstetrics and Gynecology (Maternal Fetal Medicine) and, by courtesy, of Pediatrics at the Stanford University Medical Center

    Current Research and Scholarly Interests Antepartum and intrapartum fetal monitoring Prenatal diagnosis Medical complications of pregnancy, particularly: SLE, hypertension, diabetes, malignancy A.

  • Justin Du Bois

    Justin Du Bois

    Henry Dreyfus Professor in Chemistry and Professor, by courtesy, of Chemical and Systems Biology

    Bio Research and Scholarship

    Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C?H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.

    The Du Bois group has described new tactics for the selective conversion of saturated C?H to C?N and C?O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C?H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.

    In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models.

  • Anne Dubin

    Anne Dubin

    Professor of Pediatrics (Pediatric Cardiology) at the Lucile Salter Packard Children's Hospital

    Current Research and Scholarly Interests Arrhythmia management in pediatric heart failure, especially resynchronization therapy in congenital heart disease,Radio frequency catheter ablation of pediatric arrhythmias,

  • Alexander Dunn

    Alexander Dunn

    Associate Professor of Chemical Engineering

    Current Research and Scholarly Interests My lab is deeply interested in understand how living cells sense and respond to mechanical stimuli.

  • James Dunn

    James Dunn

    Professor of Surgery (Pediatric Surgery) at the Lucile Salter Packard Children's Hospital and, by courtesy, of Bioengineering

    Current Research and Scholarly Interests Intestinal lengthening for short bowel syndrome
    Intestinal stem cell therapy for intestinal failure
    Skin derived precursor cell therapy for enteric neuromuscular dysfunction
    Intestinal tissue engineering

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