Current Research and Scholarly Interests
I have an interest in developing and applying high dimensional proteomic analysis to pediatric systemic inflammatory disease and immunodeficiency disorders, with the goal of translating this directly to patient care by identifying targets for therapy and new risk stratifications based on functional read-outs. Specifically, I am interested in understanding innate immune signaling and cytokine networks in systemic lupus erythematosus (SLE) and primary immunodeficiency with inflammatory complications, as well as normal innate immune development and the relationship between the two. I am currently working with Dr. Garry Nolan, in whose laboratory mass cytometry was initially developed and applied to the understanding of normal immunophenotype and signaling in peripheral blood samples. I am developing expertise in single-cell mass cytometry analysis of human peripheral blood samples and the different data analysis methods of high dimensional datasets. I continue to enjoy an active role in caring for children with inflammatory and immunodeficient disorders.