Bio

Honors & Awards

  • Tobacco-Related Disease Research Program (TRDRP) Postdoctoral Fellow, University of California (2018-2021)
  • Huck Graduate Dissertation Research Award, The Huck Institutes of Life Sciences, The Pennsylvania State University (2014-2017)
  • Outstanding CMIND research seminar presentations, Center for Molecular Investigation of Neurological Disorders, The Pennsylvania State University (2015)

Professional Education

  • Bachelor of Science, Tsinghua University (2008)
  • Master of Science, Tsinghua University (2011)
  • Doctor of Philosophy, Pennsylvania State University (2017)

Contact

Publications

All Publications

  • A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer. Cancer discovery Cai, H., Chew, S. K., Li, C., Tsai, M. K., Andrejka, L., Murray, C. W., Hughes, N. W., Shuldiner, E. G., Ashkin, E. L., Tang, R., Hung, K. L., Chen, L. C., Lee, S. Y., Yousefi, M., Lin, W. Y., Kunder, C. A., Cong, L., McFarland, C. D., Petrov, D. A., Swanton, C., Winslow, M. M. 2021

    Abstract

    Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multi-step process, however the importance and specific roles of many of these genes during tumor initiation, growth and progression remain unknown. Here we use a multiplexed mouse model of oncogenic KRAS-driven lung cancer to quantify the impact of forty-eight known and putative tumor suppressor genes on diverse aspects of carcinogenesis at an unprecedented scale and resolution. We uncover many previously understudied functional tumor suppressors that constrain cancer in vivo. Inactivation of some genes substantially increased growth, while the inactivation of others increases tumor initiation and/or the emergence of exceptionally large tumors. These functional in vivo analyses revealed an unexpectedly complex landscape of tumor suppression that has implications for understanding cancer evolution, interpreting clinical cancer genome sequencing data, and directing approaches to limit tumor initiation and progression.

    View details for DOI 10.1158/2159-8290.CD-20-1325

    View details for PubMedID 33608386

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