School of Medicine
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Instructor, Pediatrics - Stem Cell Transplantation
Current Research and Scholarly Interests My current research focuses on the influence of the microbiome on clinical outcomes in the pediatric oncology, hematology, and bone marrow transplant populations.
Clinical Professor, Pediatrics - Stem Cell Transplantation
Bio I did my training in Pediatrics and Hematology/ Oncology at Childrens Hospital Los Angeles where I was an attending physician for 15 years.. I joined Stanford University in 2015 as a clinical attending in the Division of Stem Cell Transplantation and Regenerative Medicine. My areas of clinical expertise have been in the areas of transplantation for immune deficiencies and immune reconstitution post HSCT. I am very interested in cellular therapies as a treatment modality for rare genetic diseases. I currently am the PI for several gene therapy trials at Stanford for various disorders including Adrenoleukodystrophy, Sickle Cell Anemia, Thalassemia and Pyruvate Kinase Deficiency. My other main areas of research have been in the neurocognitive function post HSCT. I have been involved with several national committees addressing the late effects of HSCT within the ASBMT and COG.
Gary M. Shaw
NICU Nurses Professor and Professor (Research), by courtesy, of Epidemiology and Population Health and of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly Interests Primary research interests include 1) epidemiology of birth defects, 2) gene-environment approaches to perinatal outcomes, and 3) nutrition and reproductive outcomes.
Clinical Associate Professor, Medicine - Primary Care and Population Health
Current Research and Scholarly Interests Primary care, psycho-social determinants of health & care, maternal-child health
Kate Shaw, MD MS
Clinical Associate Professor, Obstetrics & Gynecology
Current Research and Scholarly Interests My research interests include expanding access to and and improving patient experience with contraception and abortion care both domestically and globally. I am also interested in medical education and resilience among physicians and trainees.
Clinical Assistant Professor, Pediatrics
Current Research and Scholarly Interests Health- Promoting Schools in under-served rural China
Teaching Mental Health via virtual platforms
Early Childhood Development in undeserved populations
Chambers-Okamura Endowed Professor of Pediatric Orthopaedics
Bio Kevin G. Shea, MD is an orthopaedic surgeon at Stanford University Medical Center and the Lucile Packard Children?s Hospital. Dr. Shea grew up in Montana and California, graduated from the UCLA School of Medicine, and completed his orthopaedic residency at the University of Utah School of Medicine. His advanced training includes pediatric orthopaedics at Rady Children?s Hospital in San Diego, AO Fellowship in Bern Switzerland with Drs. Ganz (Hip), Dr. Diego Fernandez (Trauma), and Dr. Hans Staubli (sports), and Ilizarov Training in Lecco, Italy. He was the AOSSM Traveling Sports Medicine Fellow in 2008, and practiced in Boise, ID prior to joining the Stanford Faculty. Dr. Shea is a founding member of the PRiSM Society (Pediatric Research in Sports Medicine) and the ROCK (Research in OsteoChondritis of the Knee) Multi-center Study Group. He is a member of the AAOS (American Academy of Orthopaedic Surgeons), POSNA (Pediatric Orthopaedic Society of North America) and the AOSSM (American Orthopedic Society for Sports Medicine). In addition, Dr. Shea has authored more than 170 scientific papers and book chapters.
Professor of Pathology and of Pediatrics at the Stanford University Medical Center
Bio Hiroyuki Shimada, MD, PhD, FRCPA (Hon), is Professor of Pathology and of Pediatrics at the Stanford University Medical Center. He was born in Tokyo, Japan, and completed MD (1973) and PhD (1982) at the Yokohama City University School of Medicine, Yokohama, Japan, and also completed his pathology training at the Children's Hospital (now the Nationwide Children?s Hospital) and the Ohio State University, Columbus, Ohio, USA (1988). Before moving to the Stanford University in 2019, he was Professor of Pathology (Clinical Scholar) at the University of Southern California Keck School of Medicine and working at the Children?s Hospital Los Angeles.
Dr. Shimada was Chair of the International Neuroblastoma Pathology Committee (1999-2017) and the founder of the International Neuroblastoma Pathology Classification (INPC). As Director of the COG (Children?s Oncology Group) Neuroblastoma Pathology Reference Laboratory (since 2001), he has been actively reviewing pathology samples of ~700 neuroblastoma cases per year from United States, Canada, Australia, and New Zealand. Pathology review results according to the INPC have been providing critical information for patient stratification and protocol assignment in the COG international neuroblastoma clinical trials.
Andrew Young Shin
Clinical Professor, Pediatrics - Cardiology
Current Research and Scholarly Interests SURF PROGRAM
The SURF program is an innovative collaboration between LPCH, Stanford University Hospital and the Stanford School of Engineering. The program has focused on improving quality and safety of patient care, improving hospital operations and promoting clinical effectiveness utilizing contemporary technologies such as machine learning, mathematical optimization, simulation and a variety of statistical, probabilistic and computational tools. The program has 2 independent funding mechanism to primarily improve patient care/hospital operations and improve academics for faculty within the department of Pediatrics at LPCH.
The Clinical Effectiveness (CE) Program is a funded program that aims to understand and improve unnecessary variation in healthcare delivery in order to optimize quality of care and reduce wasteful expenditures. The CE program has developed innovative programs such as Target Based Care, an award-winning intervention to reduce variation in hospital length of stay and currently a multi-center trial involving more than 20 hospitals in North America. In 2016, the CE program included the first CE fellowship program in a pediatric training program with 3 cycles of graduates. The CE program is supported by LPCH and a philanthropic gift by Susan Choe and Thomas Tobiason.
Linda M. Dairiki Shortliffe
Stanley McCormick Memorial Professor in the School of Medicine, Emerita
Current Research and Scholarly Interests The timing for intervention in obstruction in the infant and child is poorly understood.Our group has been interested in trying to define the risks that may be involved in obstructive and infectious uropathies and discovering early signs of damage to the urinary tract and kidney. We have explored ways of imaging the urinary tract using nonionizing radiation (US, MRI). We have studied the relationships of sex steroid hormones, pregnancy, reflux, urinary tract infection and urinary tract function.
Eric Sibley, M.D., Ph.D.
Professor of Pediatrics (Gastroenterology)
Current Research and Scholarly Interests Genetic Regulation of Intestinal Development and Maturation. We study transcriptional mechanisms regulating the spatial and temporal restriction of intestine-specific gene expression during gut development. Our approach is to characterize the function of gene-specific DNA cis elements and interacting nuclear proteins in cell culture and in transgenic animals. The goal is to relate the gene-specific control mechanisms to the broader pathways specifying acquisition of a small intestinal phenotype.
Douglas Sidell, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Dr. Sidell's clinical interests include the management of children with voice and swallowing disorders, and congenital or acquired airway abnormalities. Examples of ongoing or upcoming prospective trials include an investigation into the utility of acid suppression in children with laryngomalacia, the management of vocal cord paralysis following cardiac surgery, and the management of type 1 laryngeal clefts in children.
Professor of Pathology and of Genetics
Current Research and Scholarly Interests We have a highly collaborative research program in the evolutionary genomics of cancer. We apply well-established principles of phylogenetics to cancer evolution on the basis of whole genome sequencing and functional genomics data of multiple tumor samples from the same patient. Introductions to our work and the concepts we apply are best found in the Newburger et al paper in Genome Research and the Sidow and Spies review in TIGS.
More information can be found here: http://www.sidowlab.org
Norman H. Silverman
Honorary Faculty Emeritus, Pediatrics
Current Research and Scholarly Interests My research interests center around cardiac ultrasound. I am currently working on several areas in the development of human cardiac ultrasound.
These are fetal cardiac ultrasound. intraoperative and transesophageal ultrasound imaging in children, imaging potiential for ultrasound two and three dimensional modalities in children with congenital heart disease
Associate Professor of Epidemiology and Population Health and, by courtesy, of Medicine (Immunology & Rheumatology)
Bio Julia Fridman Simard, ScD, is an Associate Professor of Epidemiology & Population Health, and, by courtesy, of Medicine in Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Simard earned her Masters and Doctorate of Science in Epidemiology degrees at the Harvard School of Public Health. During that time she trained with investigators at the Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy at Brigham and Women?s Hospital and the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center. In 2008, Dr. Simard relocated to Sweden to begin a Postdoctoral Fellowship in Clinical Epidemiology at the Karolinska Institutet in Stockholm. She became an Assistant Professor in their Clinical Epidemiology Unit in 2011, and was later honored with a Karolinska Institutet Teaching Award. Leveraging the population-based registers of Sweden, Dr. Simard initiated a national register linkage study to examine the utility of registers in Systemic Lupus Erythematosus (SLE) research and develop an extensive data repository for future epidemiologic investigations.
While maintaining a close collaboration with the Karolinska Institutet, she joined Stanford?s Epidemiology faculty as an Assistant Professor in 2013. Dr. Simard studies outcomes such as malignancy, stroke, infection, and mortality, in patients with systemic autoimmune rheumatic diseases, but her primary research focus has shifted to the intersection between reproductive epidemiology and rheumatic disease. In 2014 she was awarded a five-year K career development award from the NIH (NIAMS) to study maternal and fetal outcomes in systemic lupus pregnancy. This fueled a number of collaborations with colleagues at Stanford, throughout the US, and abroad, and a series of projects focused on the diagnosis of preeclampsia and associated risks in pregnant women with systemic lupus. Dr. Simard was recently awarded a Peter Joseph Pappas Research Grant from the Preeclampsia Foundation for her lab's work examining preeclampsia risk in high-risk populations, and a McCormick Faculty Award from Stanford Medicine to take important steps towards disentangling preeclampsia from lupus nephritis. In addition to these issues of misclassification in reproductive rheumatology questions, Dr. Simard's lab is also interested in how misclassification, missed opportunities, and misdiagnosis contribute to disparities in complex conditions such as SLE. In addition to methodologic issues around misclassification and bias and the largely clinical epi focus of her work, Dr. Simard's work examines social determinants of health and health disparities.
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric) at the Stanford University Medical Center
Current Research and Scholarly Interests The primary goal of my research is to promote the health and well being of children and adolescents with chronic pain and their families. In line with this goal, research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include brain imaging, longitudinal clinical cohort, and treatment interventions studies.
Some current research orojects include:
Learning and Memory in Pediatric Chronic Pain
Funding: NIH/NICHD R01
Description: Investigating the mechanisms underlying fear learning, extinction and disruption of fear reconsolidation in adolescents with chronic pain and health controls using behavioral and neuroimaging measures. Multi-site study with Boston Children's Hospital (Collaborator: David Borsook, MD).
Children Pain Behaviors in Context: A functional-cognitive perspective
Leading Site: University of Ghent (Collaborator: Liesbet Goubert, PhD)
Description: Identifying key antecedents and consequences that give rise to and maintain children's pain-related behaviors and investigate impact these antecedents on children's behavior and functioning through daily surveys and activity monitoring.
Manpreet K. Singh, MD MS
Associate Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests As part of the Pediatric Mood Disorders Program, Dr. Singh conducts research in the phenomenology, neurobiology, pharmacology, and genetic aspects of depression and bipolar disorder in children. These studies include brain imaging (MRI, MRS, fMRI), medication, and psychotherapy trials. She is particularly interested in risk factors for the development of major mood disorders and associated morbidities, and early intervention strategies to delay the onset and progression of symptoms.
Professor of Medicine (Infectious Diseases & Geographic Medicine) and of Microbiology and Immunology
Current Research and Scholarly Interests Our lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.
Stanford W. Ascherman, MD, FACS, Professor in Genetics
Current Research and Scholarly Interests Our laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states
Hyongsok Tom Soh
Professor of Radiology (Early Detection), of Electrical Engineering and, by courtesy, of Chemical Engineering and of Bioengineering
Bio Dr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and his Ph.D. in Electrical Engineering from Stanford University. From 1999 to 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and Agere Systems. He was a faculty member at UCSB before joining Stanford in 2015. His current research interests are in analytical biotechnology, especially in high-throughput screening, directed evolution, and integrated biosensors.
James R. Doty Professor of Neurosurgery and Neurosciences
Bio Ivan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.
Associate Professor of Medicine (Pulmonary and Critical Care Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Pulmonary Arterial Hypertension
Pulmonary Vascular Remodeling
Modulation of BMP signaling
BMP signaling in health and disease in the right ventricle of the heart
"BMP signature" in blood as a biomarker
BMP signaling in neonatal chronic lung disease
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering
Current Research and Scholarly Interests My research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.
Alfred M. Spormann
Professor of Civil and Environmental Engineering, of Chemical Engineering and, by courtesy, of Biology
Current Research and Scholarly Interests Metabolism of anaerobic microbes in diseases, bioenergy, and bioremediation
Douglass M. and Nola Leishman Professor of Cardiovascular Disease
Current Research and Scholarly Interests The general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.
Endowed Professor of Pediatric Cancer
Current Research and Scholarly Interests My research focuses primarily on the management of children, adolescents, and young adults with soft tissue sarcomas. I also have an interest in developmental therapeutics and late effects of cancer therapy,
Professor of Medicine (Stanford Center for Research in Disease Prevention)
Current Research and Scholarly Interests As Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.
Marcia L. Stefanick, Ph.D.
Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests Marcia Stefanick, Ph.D a Professor of Medicine at the Stanford Prevention Research Center, (SPRC) and Professor of Obstetrics and Gynecology, Stanford University School of Medicine.
Dr. Stefanick's research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. Her work on the effects of menopausal hormones on cardiovascular and other health outcomes in mostly healthy postmenopausal women (in the Women's Health Initiative, WHI), in women with established heart disease, (the Heart and Estrogen-progesterone Replacement Study, HERS), and in peri-menopausal and early post-menopausal women (the Postmenopausal Estrogen and Progesterone Interventions, PEPI) trials has been widely disseminated both nationally and internationally. She was also the principal investigator of two large diet trials focusing on the role of a low-fat eating pattern (including increased vegetables & fruits) on preventing breast cancer (WHI) and recurrence (Women's Healthy Eating and Living, WHEL, trial) and she conducted several medium-sized diet, exercise, and weight control trials focused on heart disease risk and body composition that have influenced national guidelines. [She is currently writing a proposal for a large national trial of physical activity in older women with cardiovascular outcomes, not just risk factors.] Her current passion is the study of Sex (and Gender) Differences in Human Physiology and Disease, the title of a course she teaches in Stanford's Human Biology program, in addition to a course entitled: Current Topics and Controversies in Women's Health. Dr. Stefanick also plays major leadership roles in Stanford's Cardiovascular Institutes Women's Heart Health Program and Stanford Cancer Institutes Cancer Prevention and Control Program.
Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology with exercise physiology as a secondary focus. Her commitment to human research directed her to a post-doctoral fellowship in Cardiovascular Disease Prevention at SPRC, which has been her academic home for nearly 30 years.
Clinical Assistant Professor, Pediatrics - Critical Care
Current Research and Scholarly Interests My research interests focus on using dissemination and implementation science tools to study and enhance care provided to patients in the pediatric ICU. I have a background in human factors research and in implementation science and am also interested in clinical effectiveness and outcomes in the PICU.
Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly Interests Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
Professor of Genetics
Current Research and Scholarly Interests We apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
David A. Stevens
Professor of Medicine, Emeritus
Current Research and Scholarly Interests Immunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.
Professor of Pediatrics (Genetics) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests My research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.
David K. Stevenson, M.D.
The Harold K. Faber Professor of Pediatrics, Senior Associate Dean, Maternal and Child Health and Professor, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly Interests Our research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.
Aaron F. Straight
Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Clinical Associate Professor, Medicine - Gastroenterology & Hepatology
Bio Dr. Sarah Streett is the Clinical Director of Inflammatory Bowel Disease at Stanford and is passionate about taking care of people with IBD. She is a national expert in the treating of complex IBD and is expanding our services to offer multi-disciplinary care and opportunities for clinical research participation. In 2018 she received the Champion of Hope Award from the Crohn?s and Colitis Foundation and serves on their Medical Advisory Board. Her interests are in fertility and pregnancy in people with IBD, developing precision approaches to IBD therapy, and in the role that the microbiome and diet play its pathogenesis. She is one of the investigators in the Stanford IBD Registry and has research projects focused on optimizing clinical outcomes in IBD, the role of the microbiota and diet in IBD and pregnancy and applying new technologies to individualizing therapy for IBD.
Dr. Streett has a national leadership role in the American Gastroenterological Association, where has been Chair of the Practice Management and Economics Committee, as well as Chair of the AGA?s initiatives on Obesity. She currently serves on the Government Affairs Committee and is a special government employee at the FDA. She has represented the interests of gastroenterologists and their patients on Capitol Hill numerous times. Dr. Streett believes strongly in a collaborative approach to give patient?s personalized care based on the latest therapies for the treatment of IBD.
Associate Professor of Emergency Medicine at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Strehlow's research is focused on global health and global emergency care. Working with in-country partners, he aims to identify the epidemiology of emergencies in developing countries and leverage the growth of emergency care systems in innovative ways to improve the overall health of the population. Specific examples include improving patient flow between the community and different level facilities and using emergency call center infrastructure to combat gender based violence.
Clinical Professor, Pediatrics - Critical Care
Current Research and Scholarly Interests My clinical pharmacology research is focused on investigating the impact of dynamic organ function on drug disposition and designing dosing strategies based on mathematical models that account for these changes in order to optimize safe medication administration in critically ill children.
Research through the REVIVE Initiative for Resuscitation Excellence investigates the quality of resuscitation during cardiopulmonary arrest. Areas of focus include early identification during the no-flow state prior to CPR initiation and quality of CPR simulation education.
Leslee L.Subak, MD
Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Urology
Current Research and Scholarly Interests My research focuses on the association of weight and urinary incontinence (UI) in women and clinical trials to test strategies to improve outcomes in women?s genitourinary health. We have shown the independent association of weight and UI and the efficacy of weight loss to treat women with UI. I also conduct studies of epidemiology, economics and cost-effectiveness, and novel interventions for UI, sexual dysfunction, vaginal atrophy, pelvic organ prolapse and menopause symptoms.
Avram Goldstein Professor in the School of Medicine and Professor, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
Associate Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center
Bio Dr. Pervez Sultan is an Associate Professor of Obstetric Anesthesiology, at Stanford University School of Medicine and also holds an Honorary Faculty position as Associate Professor at University College London. His research interests include defining, characterizing and measuring postpartum recovery.
Pervez currently serves on the Society for Obstetric Anesthesia and Perinatology (SOAP) Research Committee.
Researchgate profile: https://www.researchgate.net/profile/Pervez_Sultan2
Google Scholar profile: https://scholar.google.com/citations?user=Z2ftv_IAAAAJ&hl=en
Yang Sun, MD, PhD
Associate Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly Interests We are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.
Professor of Urology, Emeritus
Current Research and Scholarly Interests We focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
Professor of Pediatrics at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly Interests My primary interests are in the area of neonatal nutrition and developmental gastroenterology. The use of parenteral nutrition in very low birth weight infants, and the introduction of early enteral feeding to stimulate gastrointestinal maturation are my specific areas of investigative endeavors.
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Bio Using and Understanding Cell-Free Biology
Swartz Lab General Research Focus:
The current and projected research in the Swartz lab balances basic research in microbial metabolism, protein expression, and protein folding with a strong emphasis on compelling applications. The power and versatility of cell-free methods coupled with careful evaluation and engineering of these new systems enables a whole new range of applications and scientific investigation. Fundamental research on: the mechanisms and kinetics of ribosomal function, fundamental bioenergetics, basic mechanisms of protein folding, functional genomics, and metabolic pathway analysis is motivated by a variety of near- and medium term applications spanning medicine, energy, and environmental needs.
Swartz Lab Application Focus:
In the medical area , current research addresses the need for patient-specific vaccines to treat cancer. Particularly for lymphomas, there is a strong need to be able to make a new cancer vaccine for each patient. Current technologies are not practical for this demanding task, but cell-free approaches are rapid and inexpensive. We have already demonstrated feasibility in mouse tumor challenge studies and are now expanding the range of applications and working to improve the relevant technologies. Experience with these vaccines has also suggested a new and exciting format for making inexpensive and very potent vaccines for general use.
To address pressing needs for a new and cleaner energy source, we are working towards an organism that can efficiently capture solar energy and convert it into hydrogen. The first task is to develop an oxygen tolerant hydrogenase using cell-free technology to express libraries of mutated enzymes that can be rapidly screened for improved function. Even though these are very complex enzymes, we have produced active hydrogenases with our cell-free methods. We are now perfecting the screening methods for rapid and accurate identification of improved enzymes. After these new enzymes are identified, the project will progress toward metabolic engineering and bioreactor design research to achieve the scales and economies required.
To address environmental needs, we are developing an improved water filters using an amazing membrane protein, Aquaporin Z. It has the ability to reject all other chemicals and ions except water. We have efficiently expressed the protein into lipid bilayer vesicles and are now working to cast these membranes on porous supports to complete the development of a new and powerful water purification technology. The same lessons will be applied toward the development of a new class of biosensors that brings high sensitivity and selectivity.
Professor of Surgery (Pediatric Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests One of the current primary interests of the lab is to investigate the mechanisms by which hepatocellular injury and recovery is influenced and controlled by hepatocyte metabolism.
A second focus of investigation is to identify molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include newborn sepsis and Necrotizing Enterocolitis (NEC).
Daniel Sze, MD, PhD
Professor of Radiology (Interventional Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Transarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections
Senior Associate Dean, Graduate Education & Postdoctoral Affairs and Professor of Developmental Biology
Current Research and Scholarly Interests We use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish.
Jean Y. Tang MD PhD
Professor of Dermatology at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB
Professor of Neurosurgery
Bio Dr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson?s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
Joyce Teng, MD, PhD
Professor of Dermatology at the Lucile Salter Packard Children's Hospital
Bio Joyce Teng, MD, PhD is a professor in dermatology at Stanford University. She is affiliated with multiple hospitals in the area, including Lucile Salter Packard Children's Hospital (LPCH) at Stanford and Stanford Hospital and Clinics (SHC). She received her medical degree from Vanderbilt University School of Medicine and has been in practice for more than 12 years. She is one of the 5 pediatric dermatologists practicing at LPCH and one of 72 at SHC who specialize in Dermatology. She sees patients with rare genetic disorders, birthmarks, vascular anomalies and a variety of inflammatory skin diseases. She is also an experienced pediatric dermatological surgeon. Her research interests are drug discovery and novel therapy for skin disorders.
Mary Frances Nunez Teruel
Current Research and Scholarly Interests The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, CRISPR libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and tissue renegeneration, with a particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity.
Assistant Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Over the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation). Looking forward, our ability to superselectively deliver new therapies such as nanoparticles, stem cells and gene therapy will open new pathways for Interventional Radiology into the emerging field of Regenerative Medicine.
Assistant Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests The long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of ?suites? of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Clinical Professor, Psychiatry and Behavioral Sciences - Child and Adolescent Psychiatry
Current Research and Scholarly Interests Pediatric Acute-Onset Neuropsychiatric Disorder
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly Interests My research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Associate Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Assessment of vascular health s in children by non-invasive modalities
Echocardiography and outcomes in congenital heart disease
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Assistant Professor (Research) of Pediatrics (Developmental-Behavioral Pediatrics)
Bio Dr. Katherine Travis is an Assistant Professor in the Division of Developmental-Behavioral Pediatrics at Stanford University. Dr. Travis obtained her Ph.D. in Neuroscience from the University of California San Diego. Dr. Travis came to Stanford as a postdoctoral fellow to obtain training in clinical neuroscience and translational approaches to intervention. As part of her training, she was awarded a K99/R00 Pathway to Independence grant from the National Institutes of Health.
Her research uses human neuroimaging and behavioral measures to examine the neural bases of early language learning in infants and young children. The goal of her research is to develop therapies and interventions to help promote language learning outcomes in children at-risk for learning disabilities. Currently, she directs an NIH-funded clinical trial that will use diffusion MRI to assess whether there are changes in brain structure following a language intervention in the Neonatal Intensive Care Unit for preterm infants.
Susan P. and Riley P. Bechtel Medical Director and Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Tremmel studies sex differences in cardiovascular disease. Current research projects include evaluating sex differences in coronary pathophysiology, young patients presenting with myocardial infarction, the impact of stress on anginal symptoms, chronic total coronary occlusions, and vascular access site complications.
Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests Our primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
Chi-Ho Ban Tsui
Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) at the Stanford University Medical Center
Bio Dr. Tsui completed his medical training at Dalhousie University, Halifax, in 1995 after obtaining his Masters of Science in Pharmacy in 1991. These degrees followed a Diploma in Engineering and Bachelors of Science in both Mathematics and Pharmacy. Dr. Tsui completed his anesthesia residency training at the University of Alberta Hospital in Edmonton in 2000, and he received further experience in pediatric anesthesia at British Columbia Children's Hospital in Vancouver. After 16 years of practice at the University of Alberta Hospital and Stollery Children?s Hospital, Dr. Tsui was recruited to Stanford University.
Currently, Dr. Tsui is a Medical Center Line (MCL) Professor in the Department of Anesthesiology, Perioperative and Pain Medicine at Stanford University. In his position as an adult and pediatric anesthesiologist at the Stanford University Medical Center and the Lucile Packard Children?s Hospital, he specializes in regional anesthesia techniques.
Dr. Tsui is an avid and internationally recognized researcher in many areas of regional anesthesia. During his residency, Dr. Tsui developed an interest in improving the accuracy of epidural catheter placement and was issued a U.S. patent in relation to his research. Dr. Tsui has expanded his research into the use of ultrasound in regional anesthesia, with particular relevance to peripheral nerve block performance. Dr. Tsui is also responsible for development of the E-Catheter catheter-over-needle kit for use during peripheral nerve blocks. The primary objective of his research is to transform regional anesthesia from an ?art? into a reliable and reproducible ?science? by further exploring the basic scientific and clinical aspects of electrophysiological signal monitoring and integrating this with the latest advances in ultrasound.
Dr. Tsui has received the Alberta Heritage Foundation for Medical Research (AHFMR) Clinical Scholar award and has previously received research awards and grants from the Canadian Institutes of Health Research (CIHR), Canadian Anesthesiologists? Society, AHFMR, and University of Alberta. In 2015, a prestigious award, the CAS Research Recognition Award, was presented by the Canadian Anesthesiologists? Society to Dr. Tsui "in recognition of significant research contributions to regional anesthesia, acute pain management and pediatric anesthesia in Canada and around the world".
Alexander Eckehart Urban
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly Interests Complex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly Interests The long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics at the Lucile Salter Packard Children's Hospital
Bio Dr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children?s Hospital (2007), Houston and obtained his Master?s in Clinical and Translational Research at the University of Connecticut.
Clinically, Dr. Valdez has an interest in airway surgery and swallowing disorders. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.
Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure.
Dr. Valdez believes in the multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models.
Matt van de Rijn
Sabine Kohler, MD, Professor in Pathology
Current Research and Scholarly Interests Our research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
Keith Van Haren, MD
Assistant Professor of Neurology and of Pediatrics at the Stanford University Medical Center
Current Research and Scholarly Interests Our research group is dedicated to innovating care for children with degenerative brain disorders. We are particularly focused on genetic and autoimmune disorders that cause damage to the myelin (the fatty insulation around the nerves) of the brain and spinal cord. X-linked adrenoleukodystrophy (genetic) and multiple sclerosis (autoimmune) are the prototypical examples of degenerative disorders of myelin and are the two disorders we study most intensively.
Krisa Van Meurs
Rosemarie Hess Professor in Neonatal and Developmental Medicine
Current Research and Scholarly Interests My research interests include persistent pulmonary hypertension of the newborn, hypoxic respiratory failure, inhaled nitric oxide therapy, ECMO, congenital diaphragmatic hernia, neonatal clinical trials, and the use of aEEG and NIRS to detect brain injury.
Shreyas Vasanawala, MD/PhD
Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly Interests Our group is focused on developing new fast and quantitative MRI techniques.
Professor of Developmental Biology and of Genetics
Current Research and Scholarly Interests Mechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
Erin A. Vogel
Postdoctoral Research Fellow, SCRDP/ Heart Disease Prevention
Current Research and Scholarly Interests Adolescent e-cigarette use, smoking in the LGBTQ+ community, social media and well-being, multiple health risk behaviors, digital interventions for substance use
Instructor, Pediatrics - Infectious Diseases
Bio Dr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
Professor of Photon Science and of Structural Biology
Current Research and Scholarly Interests Ubiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.