School of Medicine
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Postdoctoral Research fellow, Neurosurgery
Bio I am interested in the neural circuits for motor control and how it is affected under the progression of Parkinson?s disease (PD). Currently I focus on dissecting the role of the striatal spiny projection neurons on integrating information from other brain areas, which are highly altered in PD. By incorporating various tools and state-of-the-art approaches, such as two-photon imaging/uncaging, patch-clamp electrophysiology, optogenetic manipulation of neural circuit and computational simulation, I aim to provide a comprehensive view, in the neuronal circuitry level, of how motor control is achieved and what goes wrong during the pathophysiological changes in PD, so that potential new therapeutic targets will be discovered to help PD patients.
My past training has quipped me with various research skills including:
1.Brain slice electrophysiology for studying ion channel physiology and synaptic transmission.
2.Two-photon calcium imaging for monitor subcellular neuronal activity in brain slices and in vivo.
3.Optics and microscopy development.
4.Computer programming for image processing, data analysis, and instrumental control.
5.Optogenetic techniques for controlling targeted neuronal circuits with transgenic mice and AAV viral injection.
6.Immunohistochemistry and biochemical essays.
These skills enable me not only to design and perform bench works independently but also capable to have a working model and a big picture in mind. I have a solid background in biology and neurophysiology, and my broad research skills further facilitate collaboration with experts from multidisciplinary. In summary, I have demonstrated a record for successfully completing research projects, and my strong motivation and substantial research skills have prepared me well to achieve my goal.
Postdoctoral Research fellow, Pathology
Current Research and Scholarly Interests study human neurodegeneration diseases via drosophila models
Courtney Wusthoff, MD
Assistant Professor of Neurology and, by courtesy, of Pediatrics (Neonatology) at the Stanford University Medical Center
Current Research and Scholarly Interests My projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.
Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly Interests Interactions between the genome and its cellular and signaling environments, which ultimately occur at the level of chromatin, are the key to comprehending how cell-type-specific gene expression patterns arise and are maintained during development. Research in our laboratory is focused on understanding how information encoded by the genome is integrated with the transcriptional machinery and epigenetic regulation to allow for emergence of form and function during embryogenesis.
Tony Wyss-Coray, PhD
Professor of Neurology
Current Research and Scholarly Interests Use of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.