School of Medicine
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John Ratliff, MD, FACS
Associate Professor of Neurosurgery and, by courtesy of Orthopaedic Surgery at the Stanford University Medical Center
Current Research and Scholarly Interests My research interests focus upon preventing complications in spine surgery, assessing patient outcomes after spine surgery procedures, and developing population-based metrics for assessing surgical outcomes.
Postdoctoral Research Fellow, Neurosurgery
Bio My research is currently focusing on stroke neurobiology in rodent models, exploring the pathological and molecular targets which could be modulated by pharmacological and biological compounds to promote recovery of motor and sensory function after stroke.
During five years of work at the Laboratory of Electron Microscopy, Institute of Anatomy and Anthropology, Riga Stradins University, Latvia my research initially focused on different cellular stress marker and growth factor immunoexpression and morphological alterations of myelin in the central nervous system in case of chronic alcohol and drug abuse. My contributions allowed to yield peculiarities of the brain damage caused by oxidative stress in chronic alcohol abusers and specify role of matrix metalloproteinase-9 in this damage that provided new insight regarding the antioxidant activity in the basal ganglia and cerebral cortex. During the past two years my research focused on the neuroglial cell immunoreactivity elucidating yet uncharacterized role of the neurotropic Human Herpesvirus-6 in cortical and olfactory pathway injury in pathogenesis of an unspecified encephalopathy and providing evidence for the possible virus entry site through the olfactory system.
Parallel to my work in the field of neuromorphology, I conducted research projects on clinical characterization of spontaneous, non-aneurysmal perimesencephalic subarachnoid hemorrhage and effectivity of different management strategies for cerebellar metastases in Latvia resuting in international conference publications and presentations. My extensive work on the first electronic Myasthenia gravis patient database in Latvia allowed clinical data of myasthenia patients to become more accessible for clinical research, ensured ongoing studies on different aspects of this patient population in Latvia and significantly improved the healthcare and knowledge level for the patients of this debilitating disease.
Lawrence Recht, MD
Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests Our laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.