Current Research and Scholarly Interests
The overarching goal of the Brunet lab is to understand the genetic mechanisms of aging and longevity. Aging is a highly plastic process regulated by a combination of genetic and environmental factors.
I am interested in the basic molecular components that characterize “young” and “aged” cellular states. Aging is associated with an increased onset of cancer, and I seeks to define the set of factors that can rejuvenate an aged cell, without the risk of malignant transformation. Ultimately, we might be able to design strategies to directly convert “old” cells from a patient into “young” ones, eventually developing more effective cancer therapies and prevention methods.