Professional Education

  • Bachelor of Science, University of Wisconsin Madison (2007)
  • Doctor of Philosophy, University of Wisconsin Madison (2013)

Stanford Advisors


All Publications

  • Diversity and clonal selection in the human T-cell repertoire PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Qi, Q., Liu, Y., Cheng, Y., Glanville, J., Zhang, D., Lee, J., Olshen, R. A., Weyand, C. M., Boyd, S. D., Goronzy, J. J. 2014; 111 (36): 13139-13144
  • Mechanisms shaping the naive T cell repertoire in the elderly - Thymic involution or peripheral homeostatic proliferation? EXPERIMENTAL GERONTOLOGY Qi, Q., Zhang, D. W., Weyand, C. M., Goronzy, J. J. 2014; 54: 71-74


    The ability of the human immune system to repel infections is drastically diminished with age. Elderly individuals are more susceptible to new threats and are less able to control endogenous infections. The thymus, which is the sole source of new T cells, has been proposed as a target for regenerative efforts to improve immune competence, as thymic activity is dramatically reduced after puberty. In this review, we review the role of the thymus in the maintenance of T cell homeostasis throughout life and contrast the differences in mice and humans. We propose that in humans, lack of thymic T cell generation does not explain a decline in T cell receptor diversity nor would thymic rejuvenation restore diversity. Initial studies using next generation sequencing are beginning to establish lower boundaries of T cell receptor diversity. With increasing sequencing depth and the development of new statistical models, we are now in the position to test this model and to assess the impact of age on T cell diversity and clonality.

    View details for DOI 10.1016/j.exger.2014.01.005

    View details for Web of Science ID 000334526500012

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