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We are interested in the general process of signal transduction, focusing on the role that ion channels play in this process. By means of path clamp recording and associated cell and molecular biological techniques, we have studied:1. Voltage-insensitive Ca2+ channels, Ca2+-dependent K+ channels, other downstream Ca2+ dependent effector molecules; role in cellular activation and signal transduction.2. Cystic fibrosis C1-channels in epithelial cells and lymphocytes; associated signal transduction pathways and cell biological coupling mechanisms. Phase I/II AAV-CFTR gene therapy trials.3. NFAT mediated gene transcription; modulations by kinases and phosphatases.