Bio

Clinical Focus


  • Dermatology

Academic Appointments


Professional Education


  • Residency:Stanford University Hospital and Clinics - Dermatology Department (2010) CA
  • Residency:Univ of California San Francisco (2005) CA
  • Internship:Univ of California San Francisco (2003) CA
  • Medical Education:UCSF-School of Medicine (2002) CA
  • Fellowship:Stanford University (2007) CA
  • Board Certification: Dermatology, American Board of Dermatology (2011)

Research & Scholarship

Clinical Trials


  • Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa Recruiting

    Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited blistering skin disease caused by absence of a protein known as type VII collagen. Patients with RDEB develop large, severely painful blisters and open wounds from minor trauma to their skin. This trial will create a graft, which the investigators call "LEAES," of the patient's own skin that has been genetically engineered in the investigators lab to express this missing protein. The purpose of this study is to achieve proof-of-concept for this general approach to cell-based gene therapy in humans and to set the stage for further therapeutic extension in RDEB. The investigators will basically take a subject's own cells, correct them in culture, and then transplant the corrected cells back onto them.

    View full details

Publications

Journal Articles


  • Multiple Eruptive Pilomatricomas in a 9-year-Old Boy with Glioblastoma. Pediatric dermatology Hollmig, S. T., Tollefson, M. M., Kim, J., Khuu, P. 2013; 30 (6): 756-758

    Abstract

      A 9-year-old male presented to our dermatology clinic with a recent history of developing numerous cutaneous pilomatricomas, and was subsequently discovered to have sustained a recurrence of his glioblastoma multiforme. Immunohistochemical staining of a representative pilomatricoma and his original brain tumor revealed upregulation and nuclear localization of beta-catenin, a sign associated with poor prognosis in glioblastoma. We hypothesize that the development of multiple pilomatricomas may have been a hallmark of this patient's tumor recurrence and provide support for a recent report of an association between multiple pilomatricomas and gliomatosis cerebri.

    View details for DOI 10.1111/j.1525-1470.2011.01714.x

    View details for PubMedID 22304393

  • Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. Pediatric dermatology Rangwala, S., Wysong, A., Tollefson, M. M., Khuu, P., Benjamin, L. T., Bruckner, A. L. 2012

    Abstract

    Rapidly involuting congenital hemangioma (RICH) is an uncommon, often high-flow vascular tumor that presents at birth and involutes within the first year of life. It is clinically and histologically distinct from infantile hemangioma, kaposiform hemangioendothelioma, and tufted angioma, the latter two being associated with Kasabach-Merritt phenomenon. We present a female infant with RICH and profound, transient thrombocytopenia and review the extent and clinical course of thrombocytopenia in the context of congenital vascular tumors.

    View details for PubMedID 22937785

  • Clofarabine in refractory Langerhans cell histiocytosis PEDIATRIC BLOOD & CANCER Rodriguez-Galindo, C., Jeng, M., Khuu, P., McCarville, M. B. 2008; 51 (5): 703-706

    Abstract

    Patients with multi-system Langerhans cell histiocytosis (LCH) who progress on frontline therapy have a dismal outcome. Responses to cladribine have been reported in relapsed LCH, but there are no well defined salvage regimens for LCH is refractory to therapy. The next generation deoxyadenosine analog, clofarabine, has demonstrated activity in patients with leukemia that is refractory to salvage regimens, including other nucleotide congeners; however, no experience exist on the use of clofarabine in LCH. In this report we describe significant single agent activity of clofarabine in disseminated LCH refractory to salvage regimens, including cladribine.

    View details for DOI 10.1002/pbc.21668

    View details for Web of Science ID 000259465400033

    View details for PubMedID 18623218

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