Bio

Clinical Focus


  • Pediatric Rheumatology

Academic Appointments


Honors & Awards


  • ACR/ REF/ LRI Lupus Investigator Fellowship Award, American College of Rheumatology (2004-2007)

Professional Education


  • Board Certification: Pediatrics, American Board of Pediatrics (2002)
  • Residency:UCLA Medical Center (2002) CA
  • Internship:UCLA Medical Center (2000) CA
  • Fellowship:Stanford University Pediatric Rheumatology (2006) CA
  • Medical Education:Washington University School Of Medicine (1999) MO
  • Board Certification: Pediatric Rheumatology, American Board of Pediatrics (2006)
  • BA, UC Berkeley, Molecular & Cell Biology (1995)
  • MD, Washington University, Medicine (1999)
  • MS, Stanford University, Health Research and Policy (2007)

Community and International Work


  • Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN)

    Topic

    quality improvement

    Populations Served

    juvenile idiopathic arthritis

    Location

    International

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

  • CARRA: Childhood Arthritis & Rheumatology Research Alliance

    Topic

    pediatric rheumatology collaborative

    Location

    US

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    Yes

  • Arthritis Foundation

    Topic

    juvenile arthritis

    Location

    Bay Area

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    Yes

Research & Scholarship

Current Research and Scholarly Interests


Pediatric Systemic Lupus Erythematosus;

Lupus Nephritis;

Racial/Ethnic Differences in Pediatric Lupus Patients

CARRA Registry

Publications

Journal Articles


  • European ancestry decreases the risk of early onset, severe lupus nephritis in a single center, multiethnic pediatric lupus inception cohort LUPUS Frankovich, J. D., Hsu, J. J., Sandborg, C. I. 2012; 21 (4): 421-429

    Abstract

    To determine whether pediatric SLE patients without European ancestry are at higher risk for development of severe lupus nephritis (ISN/RPS class III, IV or V).Ninety-eight of 101 patients with pediatric SLE (age <18 years at diagnosis) were enrolled. Race/ethnicity of four grandparents, socioeconomic status (SES) and language proficiency were collected. The primary outcome was time to development of severe lupus nephritis.Based on patient report of four grandparent ancestry, 29% had at least one grandparent of European ancestry (14% had all four grandparents of European ancestry). Patients without European ancestry were 46% Hispanic, 47% Asian, and 3% African American. In the entire 98 patient cohort, 12% had ?3 different ancestries. Patients without European ancestry had significantly lower SES levels and English proficiency. There was no significant difference between patients with or without European ancestry in duration of SLE, age of onset, and lag time between symptoms and diagnosis. Patients with at least one grandparent of European ancestry had a decreased risk of developing severe lupus nephritis, which remained significant after controlling for age, gender, SES and English proficiency (hazard ratio 0.4, 95% confidence interval 0.2-0.9).This study demonstrates that presence of at least one grandparent of European ancestry decreases the risk of severe lupus nephritis, a finding that is not explained by measurable socioeconomic differences and language barriers.

    View details for DOI 10.1177/0961203312437805

    View details for Web of Science ID 000301583400008

    View details for PubMedID 22427363

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