Caroline Uchechi Adanma Okorie

All Publications

• The nocturnal-polysomnogram and "non-hypoxic sleep-disordered-breathing" in children SLEEP MEDICINE Guilleminault, C., Huang, Y., Chin, W., Okorie, C. 2019; 60: 31?44

  View details for DOI 10.1016/j.sleep.2018.11.001

  View details for Web of Science ID 000473718100006

• Sleep The Handbook of Personal Health and Wellbeing for Physicians and Trainees Okorie, C. U. edited by Weiss Roberts, L., Trockel, M. Springer International Publishing. 2019
• The nocturnal-polysomnogram and "non-hypoxic sleep-disordered-breathing" in children. Sleep medicine Guilleminault, C., Huang, Y., Chin, W., Okorie, C. 2018

  Abstract

  OBJECTIVE: To characterize sleep-disordered breathing patterns not related to hypoxia resulting in fragmented sleep in children.METHODS: We reviewed the polysomnogram (PSG) data of children with sleep complaints who were being evaluated for sleep-disordered breathing and had an apnea-hypopnea-index?3. These data were compared to the recordings of the same children with nasal CPAP administered for one night and to 60 control subjects (children without any sleep complaints). A subgroup of children was monitored with esophageal manometry, but nasal cannula flow data was recorded in all cases.RESULTS: Abnormal breathing patterns, particularly flow limitation, could be seen with more severity and frequency compared to apnea or hypopnea. The observed abnormal breathing patterns were associated with EEG disturbances.CONCLUSIONS: Patterns such as flow-limitation, mouth-breathing, changes in inspiratory and expiratory time, rib-cage and expiratory muscle activity, transcutaneous CO2 electrode changes and snoring noises are all variables that should be systematically reviewed when analyzing nocturnal PSG. Current scoring guidelines emphasizes apnea-hypopnea and hypoxic-sleep disordered breathing and therefore treatment is often much delayed in this population of children with evidence of abnormal breathing patterns. Analysis of the various patterns of abnormal breathing noted above allows recognition of "non-hypoxic" sleep-disordered-breathing (SDB).

  View details for PubMedID 30578113

• Diagnosis And Management Of Sporadic Pulmonary Arteriovenous Malformation Not Associated With Hereditary Hemorrhagic Telangiectasia Okorie, C., Bhargava, S. AMER THORACIC SOC. 2016

  View details for Web of Science ID 000390749605287

• Allergic Bronchopulmonary Aspergillosis Journal of Fungi Tracy, M. C., Okorie, C. A., Foley, E. A., Moss, R. B. 2016; 2 (2): 17

  View details for DOI 10.3390/jof2020017

• Allergic Bronchopulmonary Aspergillosis. Journal of fungi (Basel, Switzerland) Tracy, M. C., Okorie, C. U., Foley, E. A., Moss, R. B. 2016; 2 (2)

  Abstract

  Allergic bronchopulmonary aspergillosis (ABPA), a progressive fungal allergic lung disease, is a common complication of asthma or cystic fibrosis. Although ABPA has been recognized since the 1950s, recent research has underscored the importance of Th2 immune deviation and granulocyte activation in its pathogenesis. There is also strong evidence of widespread under-diagnosis due to the complexity and lack of standardization of diagnostic criteria. Treatment has long focused on downregulation of the inflammatory response with prolonged courses of oral glucocorticosteroids, but more recently concerns with steroid toxicity and availability of new treatment modalities has led to trials of oral azoles, inhaled amphotericin, pulse intravenous steroids, and subcutaneously-injected anti-IgE monoclonal antibody omalizumab, all of which show evidence of efficacy and reduced toxicity.

  View details for PubMedID 29376934

• A Presentation Of Hepatopulmonary Syndrome In A Five Year Old During Evaluation For Miliary Tuberculosis Okorie, C. U., Mark, J. D. AMER THORACIC SOC. 2015

  View details for Web of Science ID 000377582808172

• Successful Treatment Of Mineral Oil Associated Lipoid Pneumonia In An Infant Okorie, C., Powers, M. AMER THORACIC SOC. 2013

  View details for Web of Science ID 000209839101412