Bio
Dr. Jaiswal's lab focuses on understanding the biology of the aging hematopoietic system. As a post-doctoral fellow, he identified a common, pre-malignant state for blood cancers by reanalysis of large sequencing datasets. This condition, termed "clonal hematopoiesis", is characterized by the presence of stem cell clones harboring certain somatic mutations, primarily in genes involved in epigenetic regulation of hematopoiesis. Clonal hematopoiesis is prevalent in the aging population and increases the risk of not only blood cancer, but also cardiovascular disease and overall mortality. Understanding the biology of these mutations and how they contribute to the development of cancer and other age-related diseases is the current focus of work in the lab. These studies utilize genetic and clinical information from large population-based cohorts to understand the impact of clonal hematopoiesis in humans. The effect of the mutations causing clonal hematopoiesis is also studied in human and mouse tissues through a combination of genomic profiling, functional assays, and mouse models of disease.
Clinical Focus
- Transfusion Medicine
- Genomics and Molecular Pathology
- Clinical Pathology
Academic Appointments
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Assistant Professor, Pathology
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Member, Bio-X
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Member, Cardiovascular Institute
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Member, Stanford Cancer Institute
Honors & Awards
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New Innovator Award, National Institutes of Health (2020)
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ASH Scholar Award, American Society of Hematology (2020)
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EvansMDS Discovery Research Award, Evans Foundation (2018)
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Transatlantic Network of Excellence, Foundation Leducq (2018)
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Career Award for Medical Scientists, Burroughs Wellcome Fund (2016)
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BroadIgnite Scholar, Broad Institute of MIT and Harvard (2016)
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Paul E. Strandjord Young Investigator Award, ACLPS (2014)
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Firestone Medal for Excellence in Research, Stanford University (2000)
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Phi Beta Kappa, Stanford University (2000)
Professional Education
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PhD Training: Stanford University School of Medicine (2010) CA
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Medical Education: Stanford University School of Medicine (2010) CA
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Board Certification: American Board of Pathology, Clinical Pathology (2017)
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Fellowship, Harvard Medical School, Transfusion Medicine (2013)
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Residency, Massachusetts General Hospital, Clinical Pathology (2014)
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PhD, Stanford University School of Medicine, Immunology (2010)
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MD, Stanford University School of Medicine (2010)
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BS, Stanford University, Biological Sciences (2000)
Patents
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Siddhartha Jaiswal, Irving L. Weissman, Ravindra Majeti, Mark P. Chao. "United States Patent 8562997 B2 Methods of treating acute myeloid leukemia by blocking CD47", The Board Of Trustees Of The Leland Stanford Junior University, Oct 22, 2013