Bio

Clinical Focus


  • International Oncology
  • Pediatric Hematology-Oncology
  • Oncology (Cancer), Pediatric

Academic Appointments


Honors & Awards


  • Fulbright Scholarship, NIH (1999)
  • Stanford Immunology Training Grant, NIH (1990)
  • National Research Servic Award, NHI (1984)

Professional Education


  • Board Certification: Pediatric Hematology-Oncology, American Board of Pediatrics (1992)
  • Fellowship:Lucile Packard Children's Hospital (1991) CA
  • Residency:Bellevue Hospital Center (1988) NY
  • Medical Education:San Carlos University of Guatemala (1984) Guatemala
  • Fellowship, Stanford University, CA, Ped Hematology/Oncology (1991)
  • Peds, NYU/Bellevue Medical Center, NY, Pediatrics (1988)
  • MD, San Carlos University, Guatemala, Medicine (1984)

Community and International Work


  • Retinoblastoma II - AHOPCA open protocol, Central America

    Topic

    Treatment of retinoblastoma in low income countries

    Partnering Organization(s)

    Central American Ped Oncology Wards

    Populations Served

    Pediatric

    Location

    International

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

Research & Scholarship

Current Research and Scholarly Interests


International Oncology, retinoblastoma, myelodysplastic syndromes, Pediatric Cancer in Low-Income Countries

Clinical Trials


  • Cancer Biology of Retinoblastoma Recruiting

    Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.

    View full details

  • Integrated Whole-Genome Analysis of Hematologic Disorders Recruiting

    To identify mutations, changes in DNA copy number, structural rearrangements, or altered microRNA/mRNA expression that are important for the initiation, progression, or treatment response of hematologic disorders.

    View full details

  • Feasibility Study of Exercises for Myeloablative Allogeneic Blood and Marrow Transplantation (BMT) Patients Not Recruiting

    Blood and marrow transplantation (BMT) is commonly used in the treatment of oncologic and hematologic disorders. Patients undergoing Hematopoietic stem cell transplantation (HSCT) are screened for functional status among other criteria to ensure that they are able to endure the rigorous treatment involved during Hematopoietic stem cell transplantation (HSCT). The patient entering the transplant process is possibly already functionally compromised from their disease, prior cancer treatment, and possible other co-morbidities. Additional factors of the transplantation that compromise the independent functional status of the patient include the high dose preparative regimen, pancytopenia, steroid-related side effects, hospitalization, transplantation complications such as infections, pulmonary alterations, acute and chronic Graft-versus-host Disease (GVHD), pain, decreased nutritional input, and other sequelae of transplantation. Physical Therapy has been utilized in this population primarily as a supportive therapy to prevent and limit the patient's functional decline. Studies have addressed general and aerobic exercise in this population but there is a paucity of research investigating the benefits of a strength-training program, particularly performed in weight-bearing, in attenuating the detrimental effects of the transplantation on functional status. This is a feasibility study questioning if an exercise program including weight-bearing strengthening exercises and cardiovascular exercise is practical for the patients to carry out as inpatients. The study will also preliminarily determine if this exercise program influences functional outcomes and level of fatigue. Such outcome measures will include 1) FiveTimes Sit-To-Stand Test, 2) Six-Minute Walk Test, 3) stair performance, 4) Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scales. The study population will include patients with lymphomas and acute leukemias undergoing matched-related donor allogeneic myeloablative Blood and marrow transplantation (BMT).

    Stanford is currently not accepting patients for this trial. For more information, please contact Grace Lu, (650) 723 - 6701.

    View full details

Teaching

2013-14 Courses


Publications

Journal Articles


  • Ionising radiation-free whole-body MRI versus (18)F-fluorodeoxyglucose PET/CT scans for children and young adults with cancer: a prospective, non-randomised, single-centre study. lancet oncology Klenk, C., Gawande, R., Uslu, L., Khurana, A., Qiu, D., Quon, A., Donig, J., Rosenberg, J., Luna-Fineman, S., Moseley, M., Daldrup-Link, H. E. 2014; 15 (3): 275-285

    Abstract

    Imaging tests are essential for staging of children with cancer. However, CT and radiotracer-based imaging procedures are associated with substantial exposure to ionising radiation and risk of secondary cancer development later in life. Our aim was to create a highly effective, clinically feasible, ionising radiation-free staging method based on whole-body diffusion-weighted MRI and the iron supplement ferumoxytol, used off-label as a contrast agent.We compared whole-body diffusion-weighted MRI with standard clinical (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT scans in children and young adults with malignant lymphomas and sarcomas. Whole-body diffusion-weighted magnetic resonance images were generated by coregistration of colour-encoded ferumoxytol-enhanced whole-body diffusion-weighted MRI scans for tumour detection with ferumoxytol-enhanced T1-weighted MRI scans for anatomical orientation, similar to the concept of integrated (18)F-FDG PET/CT scans. Tumour staging results were compared using Cohen's ? statistics. Histopathology and follow-up imaging served as the standard of reference. Data was assessed in the per-protocol population. This study is registered with ClinicalTrials.gov, number NCT01542879.22 of 23 recruited patients were analysed because one patient discontinued before completion of the whole-body scan. Mean exposure to ionising radiation was 12·5 mSv (SD 4·1) for (18)F-FDG PET/CT compared with zero for whole-body diffusion-weighted MRI. (18)F-FDG PET/CT detected 163 of 174 malignant lesions at 1325 anatomical regions and whole-body diffusion-weighted MRI detected 158. Comparing (18)F-FDG PET/CT to whole-body diffusion-weighted MRI, sensitivities were 93·7% (95% CI 89·0-96·8) versus 90·8% (85·5-94·7); specificities 97·7% (95% CI 96·7-98·5) versus 99·5% (98·9-99·8); and diagnostic accuracies 97·2% (93·6-99·4) versus 98·3% (97·4-99·2). Tumour staging results showed very good agreement between both imaging modalities with a ? of 0·93 (0·81-1·00). No adverse events after administration of ferumoxytol were recorded.Ferumoxytol-enhanced whole-body diffusion-weighted MRI could be an alternative to (18)F-FDG PET/CT for staging of children and young adults with cancer that is free of ionising radiation. This new imaging test might help to prevent long-term side-effects from radiographic staging procedures.Thrasher Research Fund and Clinical Health Research Institute at Stanford University.

    View details for DOI 10.1016/S1470-2045(14)70021-X

    View details for PubMedID 24559803

  • SIOP-PODC recommendations for graduated-intensity treatment of retinoblastoma in developing countries PEDIATRIC BLOOD & CANCER Chantada, G., Luna-Fineman, S., Sitorus, R. S., Kruger, M., Israels, T., Leal-Leal, C., Bakhshi, S., Qaddoumi, I., Abramson, D. H., Doz, F. 2013; 60 (5): 719-727

    Abstract

    Retinoblastoma remains incurable in many regions of the world. The major obstacles to cure are delayed diagnosis, poor treatment compliance, and lack of evidence-based recommendations for clinical management. Although enucleation is curative for intraocular disease, in developing countries retinoblastoma is often diagnosed after the disease has disseminated beyond the eye. A SIOP-PODC committee generated guidelines for the clinical management of retinoblastoma in developing countries and developed a classification system based on the resources available in those settings. Recommendations are provided for staging and treatment of unilateral and bilateral retinoblastoma and counseling of families for whom compliance is an issue.

    View details for DOI 10.1002/pbc.24468

    View details for Web of Science ID 000316291700003

    View details for PubMedID 23335388

  • Retinoblastoma in Central America: Report from the Central American Association of Pediatric Hematology Oncology (AHOPCA) PEDIATRIC BLOOD & CANCER Luna-Fineman, S., Barnoya, M., Bonilla, M., Fu, L., Baez, F., Rodriguez-Galindo, C. 2012; 58 (4): 545-550

    Abstract

    Retinoblastoma is highly curable in high income countries. Low income countries have poor results due to advanced disease and lack of resources. Central American Association of Pediatric Hematology Oncology (AHOPCA) aimed to standardize the approach and to improve outcomes of patients with retinoblastoma.One hundred seventy-one patients, age <18 years newly diagnosed with retinoblastoma were treated according to laterality and stage. Therapeutic modalities were: surgery (enucleation), local control (laser therapy, cryotherapy), chemotherapy, and radiation therapy. Chemotherapy consisted of vincristine, etoposide, and carboplatin (6 cycles). Outcomes were measured by overall survival. Events were abandonment of therapy and death.One hundred seventy-one patients (129 unilateral, 42 bilateral) were treated. Median age was 2 years 4 months; 112 (66%) were diagnosed before 3 years of age. 119 (92%) eyes in patients with unilateral disease were Reese-Ellsworth IV or V versus 52 (62%) eyes in patients with bilateral disease. Extraocular disease was more prevalent in unilateral disease (65% vs. 50%). Older age at diagnosis correlated with higher stage. Estimated overall survival at 60 months was 0.48?±?0.04. Outcome of patients with bilateral disease was significantly better than unilateral (62%?±?0.09 vs. 42%?±?0.05, P?=?0.0006). Thirty-eight patients (22%) refused or abandoned therapy.Protocol-directed therapy for retinoblastoma in Central America is possible. Patients present with advanced disease and outcome is significantly worse than in middle and high-income countries. Refusal and abandonment of therapy are societal events that affect outcome. Initiatives aimed at improving early diagnosis, while dedicated treatment centers are developed, are critical.

    View details for DOI 10.1002/pbc.23307

    View details for Web of Science ID 000300502800013

    View details for PubMedID 21910211

  • Abandonment of Treatment for Childhood Cancer: Recommendations of the SIOP Pediatric Oncology in Developing Countries Abandonment of Treatment Working Group. Arora R, Bagai A, Friedrich P, Gupta S, Kaur G, Koodiyedath B, Kulkarni K, Lam CG, Luna-Fineman S et al 2011; In press
  • Retinoblastoma en Guatemala: Diagnóstico Temprano Salva Vidas. Retinoblastoma en Guatemala: Diagnóstico Temprano Salva Vidas. Luna-Fineman S, Castellanos M, Barnoya M. 2010
  • Neuroblastoma Involvement of the Falx Cerebri PEDIATRIC BLOOD & CANCER Quackenbush, K. E., Luna-Fineman, S., Magee, J. F., Gundogan, M., Golobi, M., Irie, T., Fernandez, C. V. 2009; 53 (7): 1337-1339

    Abstract

    Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challenging. We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.

    View details for DOI 10.1002/pbc.22192

    View details for Web of Science ID 000271363800033

    View details for PubMedID 19821537

  • Development of Retinoblastoma Programs in Central America PEDIATRIC BLOOD & CANCER Wilimas, J. A., Wilson, M. W., Haik, B. G., Barnoya, M., Fu, L., Castellanos, M., Bonilla, M., Phillips, B., Helveston, E. M., Luna-Fineman, S., Ribeiro, R., Rodriguez-Galindo, C. 2009; 53 (1): 42-46

    Abstract

    Retinoblastoma, a curable eye tumor, is associated with poor survival in Central America (CA). To develop a retinoblastoma program in El Salvador, Guatemala, and Honduras, twinning initiatives were undertaken between local pediatric oncology centers, nonprofit foundations, St. Jude Children's Research Hospital, and the University of Tennessee Hamilton Eye Institute.The retinoblastoma program focused on developing early diagnosis programs in Honduras with national vaccination campaigns, developing treatment protocols suited to local conditions, building local networks of oncologists and ophthalmologists, training local healthcare providers, using modern donated equipment for diagnosis and treatment, and the ORBIS Cybersight consultation program and Internet meetings to further education and share expertise. Pediatric ophthalmologists and oncologists worked with foundations to treat patients locally with donated equipment and Internet consultations, or at the center in Guatemala.Number of patients successfully treated increased after the program was introduced. For 2000-2003 and 2004-2007, patients abandoning/refusing treatment decreased in Guatemala from 20 of 95 (21%) to 14 of 123 (11%) and in Honduras from 13 of 37 (35%) to 7 of 37 (19%). Survival in El Salvador was good and abandonment/refusal low for both periods. Of 18 patients receiving focal therapy for advanced disease, 14 have single remaining eyes.Development of the program in CA has decreased abandonment/refusal and enabled ophthalmologists at local centers to use modern equipment to provide better treatment. This approach might serve as a guide for developing other multispecialty programs.

    View details for DOI 10.1002/pbc.21984

    View details for Web of Science ID 000266186200010

    View details for PubMedID 19326423

  • Treating Pediatric Soft Tissue Sarcomas in a Country With Limited Resources: The Experience of the Unidad Nacional de Oncologia Pediatrica in Guatemala PEDIATRIC BLOOD & CANCER Antillon, F., Castellanos, M., Valverde, P., Luna-Fineman, S., Garrido, C., Serrato, T., Rodriguez-Galindo, C., Casanova, M., Ferrari, A. 2008; 51 (6): 760-764

    Abstract

    About 250-300 children with newly diagnosed cancer are treated each year at the Unidad Nacional de Oncologia Pediatrica in Guatemala City; less than 5% of them have soft tissue sarcomas (STS). The aim of the article was to evaluate whether the therapeutic standards achieved in STS in developed countries could be reproduced in a low-income country.We reviewed the clinical data, treatment and outcome of 80 patients, 47 cases of rhabdomyosarcoma (RMS) and 33 of non-rhabdomyosarcoma soft tissue sarcoma (NRSTS), treated between January 2000 and October 2007.Most of the RMS patients had advanced disease at diagnosis (87% groups III-IV). Their 3-year event-free survival rate (EFS) was 26.4% if abandoning the treatment was considered as an event, or 32.4% if it was censored (14 patients abandoned the treatment), and the 3-year overall survival rate (OS) was 43.5%. Local progression/relapse was the main cause of treatment failure. Among the patients with NRSTS, the EFS at 3 years was 36.4% (when abandoning the treatment was considered as an event) or 43.3% (when it was censored), and the OS was 44.2%. Outcome was satisfactory for synovial sarcoma patients, those with tumors < or =5 cm, and those with localized disease.Overall results were unsatisfactory compared to results reported from developed countries. Late diagnosis and the consequently high proportion of cases of advanced disease at diagnosis, the large number of patients failing to complete the treatment, and the poor quality of local control (in RMS) adversely influence outcome.

    View details for DOI 10.1002/pbc.21699

    View details for Web of Science ID 000260289300009

    View details for PubMedID 18680154

  • Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group BLOOD Lange, B. J., Smith, F. O., Feusner, J., Barnard, D. R., Dinndorf, P., Feig, S., Heerema, N. A., Arndt, C., Arceci, R. J., Seibel, N., Weiman, M., Dusenbery, K., Shannon, K., Luna-Fineman, S., Gerbing, R. B., Alonzo, T. A. 2008; 111 (3): 1044-1053

    Abstract

    CCG-2961 incorporated 3 new agents, idarubicin, fludarabine and interleukin-2, into a phase 3 AML trial using intensive-timing remission induction/consolidation and related donor marrow transplantation or high-dose cytarabine intensification. Among 901 patients under age 21 years, 5-year survival was 52%, and event-free survival was 42%. Survival improved from 44% between 1996 and 1998 to 58% between 2000 and 2002 (P = .005), and treatment-related mortality declined from 19% to 12% (P = .025). Partial replacement of daunomycin with idarubicin in the 5-drug induction combination achieved a remission rate of 88%, similar to historical controls. Postremission survival was 56% in patients randomized to either 5-drug reinduction or fludarabine/cytarabine/idarubicin. For patients with or without a related donor, respective 5-year disease-free survival was 61% and 50% (P = .021); respective survival was 68% and 62% (P = .425). Donor availability conferred no benefit on those with inv(16) or t(8;21) cytogenetics. After cytarabine intensification, patients randomized to interleukin-2 or none experienced similar outcomes. Factors predictive of inferior survival were age more than 16 years, non-white ethnicity, absence of related donor, obesity, white blood cell count more than 100 000 x 10(9)/L, -7/7q-, -5/5q-, and/or complex karyotype. No new agent improved outcomes; experience may have contributed to better results time.

    View details for DOI 10.1182/blood-2007-04-084293

    View details for Web of Science ID 000252792900022

    View details for PubMedID 18000167

  • Improving outcomes for children with cancer in low-income countries in Latin America: a report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO)-Part I. Pediatric blood & cancer Howard, S. C., Marinoni, M., Castillo, L., Bonilla, M., Tognoni, G., Luna-Fineman, S., Antillon, F., Valsecchi, M. G., Pui, C., Ribeiro, R. C., Sala, A., Barr, R. D., Masera, G. 2007; 48 (3): 364-369

    Abstract

    The difference in survival for children diagnosed with cancer between high- and low-income countries (LIC) continues to widen as curative therapies are developed in the former but not implemented in the latter. In 1996, the Monza International School of Pediatric Hematology/Oncology (MISPHO) was founded in an attempt to narrow this survival gap. During its sixth and seventh meetings, members recognized the problem of lack of affordability of essential drugs to treat childhood cancer in many LIC, and initiated an advocacy program. In 1998, MISPHO spawned a collaboration of Central American pediatric oncology centers: the Asociación de Hemato-Oncología Pediátrica Centroamericana (AHOPCA). AHOPCA members reported preliminary findings from several of the 10 cooperative protocols that are currently in progress. In 2003, a second regional collaborative group was formed that includes seven centers in South America. Twinning programs between MISPHO centers and centers in high-income countries (HIC) have proven invaluable to harness the resources of these centers to improve pediatric oncology care in LIC. MISPHO educational efforts include oncology nursing, supportive care, cancer-specific updates, epidemiology, and clinical research methods. Educational efforts are facilitated by educational content and online conferencing via www.cure4kids.org. Identifying preventable causes of abandonment of therapy and documenting the nutritional status of patients treated at MISPHO centers are areas of active research.

    View details for PubMedID 16883601

  • Poliovirus excretion in Guatemalan adults and children with HIV infection and children with cancer BIOLOGICALS Asturias, E. J., Grazioso, C. F., Luna-Fineman, S., Torres, O., Halsey, N. A. 2006; 34 (2): 109-112

    Abstract

    More than 20 patients with persistent poliovirus infections have been identified and reported to WHO. To date, almost all of these patients have had B-cell immune deficiency disorders. Since there are limited data on patients with HIV infection who have received oral poliovirus vaccine (OPV), we studied adults and children to determine if persons with acquired immunodeficiency due to HIV infection or cancer chemotherapy in a developing country setting had prolonged excretion of polioviruses. Stool samples from 94 HIV-infected children and 101 adults and 50 children surviving cancer in Guatemala City were cultured for polioviruses. No polioviruses were detected in any of the 195 persons with HIV infection or the 50 with cancer. The evidence from this and other studies indicates that the persistent poliovirus excretion in HIV-infected individuals is an unlikely event.

    View details for DOI 10.1016/j.biologicals.2006.03.002

    View details for Web of Science ID 000238304800007

    View details for PubMedID 16682223

  • Myelodysplastic and myeloproliferative disorders of childhood: A study of 167 patients BLOOD Luna-Fineman, S., Shannon, K. M., Atwater, S. K., Davis, J., Masterson, M., Ortega, J., Sanders, J., Steinherz, P., Weinberg, V., Lange, B. J. 1999; 93 (2): 459-466

    Abstract

    Myelodysplastic syndromes (MDS) and myeloproliferative syndromes (MPS) of childhood are a heterogeneous group of clonal disorders of hematopoiesis with overlapping clinical features and inconsistent nomenclature. Although a number of genetic conditions have been associated with MDS and MPS, the overall contribution of inherited predispositions is uncertain. We report a retrospective study examining clinical features, genetic associations, and outcomes in 167 children with MDS and MPS. Of these patients, 48 had an associated constitutional disorder. One hundred one patients had adult-type myelodysplastic syndrome (A-MDS), 60 had juvenile myelomonocytic leukemia (JMML), and 6 infants with Down syndrome had a transient myeloproliferative syndrome (TMS). JMML was characterized by young age at onset and prominent hepatosplenomegaly, whereas patients with A-MDS were older and had little or no organomegaly. The most common cytogenetic abnormalities were monosomy 7 or del(7q) (53 cases); this was common both in patients with JMML and those with A-MDS. Leukemic transformation was observed in 32% of patients, usually within 2 years of diagnosis. Survival was 25% at 16 years. Favorable prognostic features at diagnosis included age less than 2 years and a hemoglobin F level of less than 10%. Older patients tended to present with an adult-type MDS that is accommodated within the French-American-British system. In contrast, infants and young children typically developed unique disorders with overlapping features of MDS and MPS. Although the type and intensity of therapy varied markedly in this study, the overall outcome was poor except in patients with TMS.

    View details for Web of Science ID 000077970900006

    View details for PubMedID 9885207

  • Langerhans cell histiocytosis diagnosed by fine needle biopsy ARCHIVES OF OPHTHALMOLOGY Harbour, J. W., Char, D. H., Ljung, B. M. 1997; 115 (9): 1212-1213

    View details for Web of Science ID A1997XV75900028

    View details for PubMedID 9298073

  • CHILDHOOD MONOSOMY-7 - EPIDEMIOLOGY, BIOLOGY, AND MECHANISTIC IMPLICATIONS BLOOD LUNAFINEMAN, S., Shannon, K. M., Lange, B. J. 1995; 85 (8): 1985-1999

    View details for Web of Science ID A1995QU09200001

    View details for PubMedID 7718870

  • HUMAN CYTOTOXIC LYMPHOCYTES-T SPECIFIC FOR AUTOLOGOUS FOLLICULAR LYMPHOMA RECOGNIZE IMMUNOGLOBULIN IN A MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTED FASHION CANCER LUNAFINEMAN, S., Lee, J. E., WESLEY, P. K., CLAYBERGER, C., KRENSKY, A. M. 1992; 70 (8): 2181-2186

    Abstract

    Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion.In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma.These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor.These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.

    View details for Web of Science ID A1992JT85900027

    View details for PubMedID 1394049

  • INTERLEUKIN-3 IS A GROWTH-FACTOR FOR HUMAN FOLLICULAR B-CELL LYMPHOMA JOURNAL OF EXPERIMENTAL MEDICINE CLAYBERGER, C., LUNAFINEMAN, S., Lee, J. E., Pillai, A., Campbell, M., Levy, R., KRENSKY, A. M. 1992; 175 (2): 371-376

    Abstract

    More than one-half of adults with non-Hodgkin's B cell lymphomas present with low-grade follicular lymphomas. These tumor cells are found in close association with follicular T lymphocytes and dendritic cells, suggesting that the surrounding cells may play a role in the support of follicular tumors. Supernatants from activated human peripheral blood lymphocytes were found to promote the in vitro proliferation of follicular tumor cells. This effect was entirely due to interleukin 3 (IL-3), a factor generally thought to cause the growth and differentiation of immature hematopoietic cells. IL-3 receptors were detected on fresh isolates of all primary follicular cell tumors examined. These findings suggest that follicular cell tumors may be dependent in vivo on IL-3 and that therapies directed against IL-3, its receptor, or the T cells that produce it may be effective treatment for follicular lymphoma.

    View details for Web of Science ID A1992HB06100007

    View details for PubMedID 1732410

  • CORTICOSTEROID PRETREATMENT FOR POTENTIAL CONTRAST REACTIONS IN CHILDREN WITH LYMPHORETICULAR CANCER - A WORD OF CAUTION AMERICAN JOURNAL OF ROENTGENOLOGY LUNAFINEMAN, S., HEALY, M. V., Parker, B. R. 1990; 155 (2): 357-358

    View details for Web of Science ID A1990DP36600027

    View details for PubMedID 2115268

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