Community Academic Profiles - Faculty & Researchers

All Publications

Tracking Blood Flow Changes in the Brains of Neonates using Angular-coherence-based Power Doppler Jakovljevic, M., Yoon, B., Abou-Elkacem, L., Rubesova, E., Dahl, J., Byram, B. C., Ruiter, N. V. SPIE-INT SOC OPTICAL ENGINEERING. 2019
View details for DOI 10.1117/12.2513554

View details for Web of Science ID 000471826100014
Estimating Signal and Structured Noise in Ultrasound Data using Prediction-Error Filters Jennings, J., Jakovljevic, M., Biondi, E., Dahl, J., Biondi, B., Byram, B. C., Ruiter, N. V. SPIE-INT SOC OPTICAL ENGINEERING. 2019
View details for DOI 10.1117/12.2513514

View details for Web of Science ID 000471826100024
Local speed of sound estimation in tissue using pulse-echo ultrasound: Model-based approach JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA Jakovljevic, M., Hsieh, S., Ali, R., Loo Kung, G., Hyun, D., Dahl, J. J. 2018; 144 (1): 254?66
View details for DOI 10.1121/1.5043402

View details for Web of Science ID 000440810900037
Blocked Elements in 1-D and 2-D Arrays-Part I: Detection and Basic Compensation on Simulated and In Vivo Targets. IEEE transactions on ultrasonics, ferroelectrics, and frequency control Jakovljevic, M., Pinton, G. F., Dahl, J. J., Trahey, G. E. 2017; 64 (6): 910-921
Abstract

During a transcostal ultrasound scan, ribs and other highly attenuating and/or reflective tissue structures can block parts of the array. Blocked elements tend to limit the acoustic window and impede visualization of structures of interest. Here, we demonstrate a method to detect blocked elements and we measure the loss of image quality they introduce in simulation and in vivo. We utilize a fullwave simulation tool and a clinical ultrasound scanner to obtain element signals from fully sampled matrix arrays during simulated and in vivo transcostal liver scans, respectively. The elements that were blocked by a rib showed lower average signal amplitude and lower average nearest-neighbor cross correlation than the elements in the remainder of the 2-D aperture. The growing receive-aperture B-mode images created from the element data indicate that the signals on blocked elements are dominated by noise and that turning them OFF has a potential to improve visibility of liver vasculature. Adding blocked elements to the growing receive apertures for five in vivo transcostal acquisitions resulted in average decrease in vessel contrast and contrast to noise ratio of 19% and 10%, respectively.

View details for DOI 10.1109/TUFFC.2017.2683559

View details for PubMedID 28328504
Blocked Elements in 1-D and 2-D Arrays-Part II: Compensation Methods as Applied to Large Coherent Apertures. IEEE transactions on ultrasonics, ferroelectrics, and frequency control Jakovljevic, M., Bottenus, N., Kuo, L., Kumar, S., Dahl, J. J., Trahey, G. E. 2017; 64 (6): 922-936
Abstract

In Part I of this paper, we detected elements blocked by ribs during simulated and in vivo transcostal liver scans, and we turned those elements OFF to compensate for the loss in visibility of liver vasculature. Here, we apply blocked-element detection and adaptive compensation to large synthetic-aperture (SA) data collected through rib samples ex vivo, in order to reduce near-field clutter and to recover lateral resolution. To construct large synthetic transmit and receive apertures, we collected the individual-channel signals from a fully sampled matrix array at multiple and known array locations across the tissue samples. The blocked elements in SAs were detected using the method presented in Part I and retroactively turned OFF, while the subapertures covering intercostal spaces were either compounded, or coherently summed using uniform and adaptive element-weighting schemes. Turning OFF the blocked elements reduced the reverberation clutter by 5 dB on average. Adaptive weighing of the nonblocked elements to rescale the attenuated spatial frequencies reduced sidelobe levels by up to 5 dB for the transcostal acquisitions, and demonstrated a potential to restore lateral resolution to the nonblocked levels. In addition, the arrival-time surfaces were reconstructed to estimate the aberration from intercostal spaces and to offer further means to compensate for the loss of focus quality in transthoracic imaging.

View details for DOI 10.1109/TUFFC.2017.2683562

View details for PubMedID 28328505
Implementation of swept synthetic aperture imaging MEDICAL IMAGING 2015: ULTRASONIC IMAGING AND TOMOGRAPHY Bottenus, N., Jakovljevic, M., Boctor, E., Trahey, G. E. 2015; 9419
View details for DOI 10.1117/12.2081434

View details for Web of Science ID 000355579600013
Short-Lag Spatial Coherence Imaging on Matrix Arrays, Part II: Phantom and In Vivo Experiments IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL Jakovljevic, M., Byram, B. C., Hyun, D., Dahl, J. J., Trahey, G. E. 2014; 61 (7): 1113-1122
Abstract

In Part I of the paper, we demonstrated through simulation the potential of volumetric short-lag spatial coherence (SLSC) imaging to improve visualization of hypoechoic targets in three dimensions. Here, we demonstrate the application of volumetric SLSC imaging in phantom and in vivo experiments using a clinical 3-D ultrasound scanner and matrix array. Using a custom single-channel acquisition tool, we collected partially beamformed channel data from the fully sampled matrix array at high speeds and created matched Bmode and SLSC volumes of a vessel phantom and in vivo liver vasculature. 2-D and 3-D images rendered from the SLSC volumes display reduced clutter and improved visibility of the vessels when compared with their B-mode counterparts. We use concurrently acquired color Doppler volumes to confirm the presence of the vessels of interest and to define the regions inside the vessels used in contrast and contrast-to-noise ratio (CNR) calculations. SLSC volumes show higher CNR values than their matched B-mode volumes, while the contrast values appear to be similar between the two imaging methods.

View details for DOI 10.1109/TUFFC.2014.3011

View details for Web of Science ID 000338665500005

View details for PubMedID 24960701

View details for PubMedCentralID PMC4234201
Short-Lag Spatial Coherence Imaging on Matrix Arrays, Part I: Beamforming Methods and Simulation Studies IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL Hyun, D., Trahey, G. E., Jakovljevic, M., Dahl, J. J. 2014; 61 (7): 1101-1112
Abstract

Short-lag spatial coherence (SLSC) imaging is a beamforming technique that has demonstrated improved imaging performance compared with conventional B-mode imaging in previous studies. Thus far, the use of 1-D arrays has limited coherence measurements and SLSC imaging to a single dimension. Here, the SLSC algorithm is extended for use on 2-D matrix array transducers and applied in a simulation study examining imaging performance as a function of subaperture configuration and of incoherent channel noise. SLSC images generated with a 2-D array yielded superior contrast-to-noise ratio (CNR) and texture SNR measurements over SLSC images made on a corresponding 1-D array and over B-mode imaging. SLSC images generated with square subapertures were found to be superior to SLSC images generated with subapertures of equal surface area that spanned the whole array in one dimension. Subaperture beamforming was found to have little effect on SLSC imaging performance for subapertures up to 8 x 8 elements in size on a 64 � 64 element transducer. Additionally, the use of 8 x 8, 4 x 4, and 2 x 2 element subapertures provided 8, 4, and 2 times improvement in channel SNR along with 2640-, 328-, and 25-fold reduction in computation time, respectively. These results indicate that volumetric SLSC imaging is readily applicable to existing 2-D arrays that employ subaperture beamforming.

View details for DOI 10.1109/TUFFC.2014.3010

View details for Web of Science ID 000338665500004

View details for PubMedID 24960700

View details for PubMedCentralID PMC4235772
Ultrasonic Multipath and Beamforming Clutter Reduction: A Chirp Model Approach IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL Byram, B., Jakovljevic, M. 2014; 61 (3): 428-440
Abstract

In vivo ultrasonic imaging with transducer arrays suffers from image degradation resulting from beamforming limitations, including diffraction-limited beamforming and beamforming degradation caused by tissue inhomogeneity. Additionally, based on recent studies, multipath scattering also causes significant image degradation. To reduce degradation from both sources, we propose a model-based signal decomposition scheme. The proposed algorithm identifies spatial frequency signatures to decompose received wavefronts into their most significant scattering sources. Scattering sources originating from a region of interest are used to reconstruct decluttered wavefronts, which are beamformed into decluttered RF scan lines or A-lines. To test the algorithm, ultrasound system channel data were acquired during liver scans from 8 patients. Multiple data sets were acquired from each patient, with 55 total data sets, 43 of which had identifiable hypoechoic regions on normal B-mode images. The data sets with identifiable hypoechoic regions were analyzed. The results show the decluttered B-mode images have an average improvement in contrast over normal images of 7.3 � 4.6 dB. The contrast-to-noise ratio (CNR) changed little on average between normal and decluttered Bmode, -0.4 � 5.9 dB. The in vivo speckle SNR decreased; the change was -0.65 � 0.28. Phantom speckle SNR also decreased, but only by -0.40 � 0.03.

View details for DOI 10.1109/TUFFC.2014.2928

View details for Web of Science ID 000332609400006

View details for PubMedID 24569248
Transcostal Imaging with Large Coherent Apertures: Ex Vivo Studies 2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) Jakovljevic, M., Kumar, S., Kuo, L., Trahey, G. E. 2014: 1698-1701
View details for DOI 10.1109/ULTSYM.2014.0421

View details for Web of Science ID 000352792500419
IN VIVO APPLICATION OF SHORT-LAG SPATIAL COHERENCE IMAGING IN HUMAN LIVER ULTRASOUND IN MEDICINE AND BIOLOGY Jakovljevic, M., Trahey, G. E., Nelson, R. C., Dahl, J. J. 2013; 39 (3): 534-542
Abstract

We present the results of a patient study conducted to assess the performance of two novel imaging methods, namely short-lag spatial coherence (SLSC) and harmonic spatial coherence imaging (HSCI), in an in�vivo liver environment. Similar in appearance to the B-mode images, SLSC and HSCI images are based solely on the spatial coherence of fundamental and harmonic echo data, respectively, and do not depend on the echo magnitude. SLSC and HSCI suppress incoherent echo signals and thus tend to reduce clutter. The SLSC and HSCI images of 17 patients demonstrated sharper delineation of blood vessel walls, suppressed clutter inside the vessel lumen, and showed reduced speckle in surrounding tissue compared to matched B-modes. Target contrast and contrast-to-noise ratio (CNR) show statistically significant improvements between fundamental B-mode and SLSC imaging and between harmonic B-mode and HSCI imaging (in all cases p�<�0.001). The magnitude of improvement in contrast and CNR increases as the overall quality of B-mode images decreases. Poor-quality fundamental B-mode images (where image quality classification is based on both contrast and CNR) exhibit the highest improvements in both contrast and CNR (288% improvement in contrast and 533% improvement in CNR).

View details for DOI 10.1016/j.ultrasmedbio.2012.09.022

View details for Web of Science ID 000314872200015

View details for PubMedID 23347642

View details for PubMedCentralID PMC3638043
Identification and Impact of Blocked Elements in 1-D and 2-D Arrays 2013 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) Jakovljevic, M., Dahl, J., Trahey, G. E. 2013: 1288-1291
View details for DOI 10.1109/ULTSYM.2013.0331

View details for Web of Science ID 000336665300328
Harmonic Spatial Coherence Imaging: An Ultrasonic Imaging Method Based on Backscatter Coherence IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL Dahl, J. J., Jakovljevic, M., Pinton, G. F., Trahey, G. E. 2012; 59 (4): 648-659
Abstract

We introduce a harmonic version of the short-lag spatial coherence (SLSC) imaging technique, called harmonic spatial coherence imaging (HSCI). The method is based on the coherence of the second-harmonic backscatter. Because the same signals that are used to construct harmonic B-mode images are also used to construct HSCI images, the benefits obtained with harmonic imaging are also obtained with HSCI. Harmonic imaging has been the primary tool for suppressing clutter in diagnostic ultrasound imaging, however secondharmonic echoes are not necessarily immune to the effects of clutter. HSCI and SLSC imaging are less sensitive to clutter because clutter has low spatial coherence. HSCI shows favorable imaging characteristics such as improved contrast-to-noise ratio (CNR), improved speckle SNR, and better delineation of borders and other structures compared with fundamental and harmonic B-mode imaging. CNRs of up to 1.9 were obtained from in vivo imaging of human cardiac tissue with HSCI, compared with 0.6, 0.9, and 1.5 in fundamental B-mode, harmonic B-mode, and SLSC imaging, respectively. In vivo experiments in human liver tissue demonstrated SNRs of up to 3.4 for HSCI compared with 1.9 for harmonic B-mode. Nonlinear simulations of a heart chamber model were consistent with the in vivo experiments.

View details for DOI 10.1109/TUFFC.2012.2243

View details for Web of Science ID 000303405500004

View details for PubMedID 22547276

View details for PubMedCentralID PMC3342045
Compact beveled fiber optic probe design for enhanced depth discrimination in epithelial tissues OPTICS EXPRESS Nieman, L. T., Jakovljevic, M., Sokolov, K. 2009; 17 (4): 2780-2796
Abstract

We report the development and evaluation of a simple compact probe that incorporates multiple beveled fibers for depth sensitive detection of spectroscopic signals in vivo. We evaluated three probes with bevel angles 35, 40, and 45 degrees for their collection efficiency and depth resolution using a thin highly scattering white substrate and found that a 40 degree bevel provides the best characteristics for depth-resolved spectroscopy. The depth sensitivity of the probe with 40 degree beveled fibers was then evaluated using multilayer phantoms with scattering properties mimicking precancerous tissue and in vivo on normal human oral mucosa. The results demonstrate that the use of multiple beveled fibers has the capability to simultaneously collect scattering spectra from a range of depths within epithelial tissue that has the potential to provide further significant improvement of detection and monitorin of epithelial precancers.

View details for DOI 10.1364/OE.17.002780

View details for Web of Science ID 000263432500073

View details for PubMedID 19219183

COVID-19 Updates

Stanford Medicine is closely monitoring the outbreak of novel coronavirus (COVID-19). A new page is dedicated to the latest information and developments about COVID-19.

Follow Stanford Medicine

��

Health Care

Healing through compassion and world-class science

Research

Fueling discovery and innovation to advance human health

Education

Empowering tomorrow's leading physicians and scientists

Faculty

Students

Community

RACIAL JUSTICE

Our Pledge

Racism and discrimination are direct affronts to Stanford Medicine?s values. Read our leaders? pledge on racial equity.

About
Stanford Medicine

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies.

Tracking spread of coronavirus in Bay Area

Stanford Medicine researchers are screening diagnostic samples to identify known coronavirus variants circulating in the Bay Area, including those from the United Kingdom, South Africa and Brazil.

covid-19 research at Stanford Medicine

Our scientists have launched dozens of research projects as part of the global response to COVID-19. Some aim to prevent, diagnose and treat the disease; others aim to understand how it spreads and how people?s immune systems respond to it.

research

Marko Jakovljevic

Postdoctoral Research Fellow, Radiology

Bio

Bio

Professional Education

Stanford Advisors

Patents

Research & Scholarship

Current Research and Scholarly Interests

Publications

All Publications

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Find a doctor

Clinics & Services

Research Resources

Professional Training

Education Resources

COVID-19 Updates

Follow Stanford Medicine

Health Care

Research

Education

Our Pledge

About
Stanford Medicine

Tracking spread of coronavirus in Bay Area

Brain aging immune-driven, reversible

From the Special Forces to medicine

Best of 2020: Stanford Medicine?s top podcasts

Site Navigation:

Footer Links:

Stanford Medicine Resources:

Marko Jakovljevic

Postdoctoral Research Fellow, Radiology

Bio

Bio

Professional Education

Stanford Advisors

Patents

Research & Scholarship

Current Research and Scholarly Interests

Publications

All Publications

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

You are Here:

Current Tab: 6

COVID-19 Updates

Follow Stanford Medicine

Health Care

Research

Education

Our Pledge

AboutStanford Medicine

Tracking spread of coronavirus in Bay Area

Brain aging immune-driven, reversible

From the Special Forces to medicine

Best of 2020: Stanford Medicine?s top podcasts

Site Navigation:

Footer Links:

Stanford Medicine Resources:

About
Stanford Medicine