Latest information on COVID-19

Stanford Medicine is closely monitoring the COVID-19 pandemic. Get the latest news on COVID-19 testing, treatment, tracking data, and medical research.

Racism and discrimination are direct affronts to Stanford Medicine?s values. Read our leaders? pledge on racial equity.

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies.

Analyzing a national cancer database, Stanford Medicine researchers find a bump in diagnoses at 65, suggesting that many wait for Medicare to kick in before they seek care.

Our scientists have launched dozens of research projects as part of the global response to COVID-19. Some aim to prevent, diagnose and treat the disease; others aim to understand how it spreads and how people?s immune systems respond to it.

A Stanford Medicine team offered guidance in crafting a COVID-19 response for the Oglala Lakota Nation.

Medical students recently learned where they would be heading for their residencies.

Sharon Hampton is focusing on patient equity as a nursing leader at Stanford Health Care. Getting to know patients and staff is key, she says.

Bio

Professional Education


  • Doctor of Philosophy, University of Texas at Austin, Biomedical Engineering (2020)
  • Master of Science in Engineering, University of Texas at Austin, Biomedical Engineering (2018)
  • Master of Engineering, Tokyo Institute of Technology, Electrochemistry (2015)
  • Bachelor of Science, Tokyo University of Science, Applied Chemistry (2013)

Stanford Advisors


Publications

All Publications


  • Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes PLOS ONE Takematsu, E., Spencer, A., Auster, J., Chen, P., Graham, A., Martin, P., Baker, A. B. 2020; 15 (2): e0225267

    Abstract

    Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently effective in clinical trials. An understanding of the changes in gene expression in the skin of diabetic patients may provide insight into the processes and mechanisms that precede the formation of non-healing ulcers. In this study, we investigated genome wide changes in gene expression in skin between patients with type 2 diabetes and non-diabetic patients using next generation sequencing. We compared the gene expression in skin samples taken from 27 patients (13 with type 2 diabetes and 14 non-diabetic). This information may be useful in identifying the causal factors and potential therapeutic targets for the prevention and treatment of diabetic related diseases.

    View details for DOI 10.1371/journal.pone.0225267

    View details for Web of Science ID 000535227900006

    View details for PubMedID 32084158

    View details for PubMedCentralID PMC7034863

  • In vivo osteoconductivity of surface modified Ti-29Nb-13Ta-4.6Zr alloy with low dissolution of toxic trace elements. PloS one Takematsu, E. n., Noguchi, K. n., Kuroda, K. n., Ikoma, T. n., Niinomi, M. n., Matsushita, N. n. 2018; 13 (1): e0189967

    Abstract

    Simulated Body Fluid (SBF) has served as a useful standard to check the bioactivity of implant materials for years. However, it is not perfectly able to imitate human serum; sometimes disparities between the SBF test and animal test were confirmed. Therefore, to ensure the reliability of the results of the SBF test obtained from our previous study, an animal study was performed to check osteoconductivity of surface modified implant materials. Three types of solution processes, hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE), were performed on the Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) to improve its bioactivity, and their bioactivities were measured in vivo using bone-implant contacts (BICs). BICs of the HE- and H-treated samples were significantly higher than that of the control. Metal ion diffusion towards the bone was also evaluated to examine the adverse effect of metal ions. No metal ion diffusion was observed, indicating the safety of our solution processed implant materials.

    View details for DOI 10.1371/journal.pone.0189967

    View details for PubMedID 29342150

    View details for PubMedCentralID PMC5771579

  • Bioactive surface modification of Ti-29Nb-13Ta-4.6Zr alloy through alkali solution treatments. Materials science & engineering. C, Materials for biological applications Takematsu, E. n., Katsumata, K. n., Okada, K. n., Niinomi, M. n., Matsushita, N. n. 2016; 62: 662?67

    Abstract

    Bioactive surface modification of Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) was performed through three different alkali solution treatments, including the electrochemical (E), hydrothermal (H), and hydrothermal-electrochemical (HE) processes; all of the processes lead to the formation of sodium-contained amorphous titanium oxide layers on TNTZ samples. The TNTZ samples subjected to the E, H, and HE processes exhibit a flat surface, smooth and fine mesh-like structure surface, and rough mesh-like structure surface, respectively. In the bioactive test, namely, simulated body fluid test, apatite inductivity increases as the surface morphology becomes rough. The order of inductivity for the three processes was HE>H>E. The surface chemical composition also affects the apatite induction ability. The surface with fewer niobium species exhibits better apatite inductivity.

    View details for DOI 10.1016/j.msec.2016.01.041

    View details for PubMedID 26952470

  • Adhesive strength of bioactive oxide layers fabricated on TNTZ alloy by three different alkali-solution treatments. Journal of the mechanical behavior of biomedical materials Takematsu, E. n., Cho, K. n., Hieda, J. n., Nakai, M. n., Katsumata, K. n., Okada, K. n., Niinomi, M. n., Matsushita, N. n. 2016; 61: 174?81

    Abstract

    Bioactive oxide layers were fabricated on Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) by three different alkali solution treatments: hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE). The adhesive strength of the oxide layer to the TNTZ substrate was measured to determine whether this process achieves sufficient adhesive strength for implant materials. Samples subjected to the HE process, in which a current of 15mA/cm(2) was applied at 90C for 1h (HE90-1h), exhibited a comparatively higher adhesive strength of approximately 18MPa while still maintaining a sufficiently high bioactivity. Based on these results, an oxide layer fabricated on TNTZ by HE90-1h is considered appropriate for practical biomaterial application, though thicker oxide layers with many cracks can lead to a reduced adhesive strength.

    View details for DOI 10.1016/j.jmbbm.2015.12.046

    View details for PubMedID 26866453

Home | Stanford Medicine

Latest information on COVID-19

Stanford Medicine is closely monitoring the COVID-19 pandemic. Get the latest news on COVID-19 testing, treatment, tracking data, and medical research.

Racism and discrimination are direct affronts to Stanford Medicine?s values. Read our leaders? pledge on racial equity.

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies.

Analyzing a national cancer database, Stanford Medicine researchers find a bump in diagnoses at 65, suggesting that many wait for Medicare to kick in before they seek care.

Our scientists have launched dozens of research projects as part of the global response to COVID-19. Some aim to prevent, diagnose and treat the disease; others aim to understand how it spreads and how people?s immune systems respond to it.

A Stanford Medicine team offered guidance in crafting a COVID-19 response for the Oglala Lakota Nation.

Medical students recently learned where they would be heading for their residencies.

Sharon Hampton is focusing on patient equity as a nursing leader at Stanford Health Care. Getting to know patients and staff is key, she says.

Home | Stanford Medicine

Latest information on COVID-19

Stanford Medicine is closely monitoring the COVID-19 pandemic. Get the latest news on COVID-19 testing, treatment, tracking data, and medical research.

Racism and discrimination are direct affronts to Stanford Medicine?s values. Read our leaders? pledge on racial equity.

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies.

Analyzing a national cancer database, Stanford Medicine researchers find a bump in diagnoses at 65, suggesting that many wait for Medicare to kick in before they seek care.

Our scientists have launched dozens of research projects as part of the global response to COVID-19. Some aim to prevent, diagnose and treat the disease; others aim to understand how it spreads and how people?s immune systems respond to it.

A Stanford Medicine team offered guidance in crafting a COVID-19 response for the Oglala Lakota Nation.

Medical students recently learned where they would be heading for their residencies.

Sharon Hampton is focusing on patient equity as a nursing leader at Stanford Health Care. Getting to know patients and staff is key, she says.

Home | Stanford Medicine

Latest information on COVID-19

Stanford Medicine is closely monitoring the COVID-19 pandemic. Get the latest news on COVID-19 testing, treatment, tracking data, and medical research.

Racism and discrimination are direct affronts to Stanford Medicine?s values. Read our leaders? pledge on racial equity.

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies.

Analyzing a national cancer database, Stanford Medicine researchers find a bump in diagnoses at 65, suggesting that many wait for Medicare to kick in before they seek care.

Our scientists have launched dozens of research projects as part of the global response to COVID-19. Some aim to prevent, diagnose and treat the disease; others aim to understand how it spreads and how people?s immune systems respond to it.

A Stanford Medicine team offered guidance in crafting a COVID-19 response for the Oglala Lakota Nation.

Medical students recently learned where they would be heading for their residencies.

Sharon Hampton is focusing on patient equity as a nursing leader at Stanford Health Care. Getting to know patients and staff is key, she says.