Paul C. Grimm

Professor of Pediatrics (Nephrology)

Clinical Focus

Pediatric Nephrology
pediatric renal transplantation
Cystinosis

Academic Appointments

Professor - University Medical Line, Pediatrics - Nephrology
Member, Maternal & Child Health Research Institute (MCHRI)

Administrative Appointments

Pediatric Nephrology Fellowship Director, LPCH at Stanford (2007 - Present)
Medical Director of Cystinosis Clinlc, LPCH at Stanford (2011 - Present)
Medical Director of Pediatric Kidney Transplant Program, LPCH at Stanford (2012 - Present)

Honors & Awards

Member, American Board of Pediatrics-Pediatric Nephrology Subboard (2010-2018)

Boards, Advisory Committees, Professional Organizations

Scientific Advisory Board Member, Cystinosis Research Foundation (2016 - Present)
Board Member, Improve Renal Outcomes Collaborative (2021 - Present)

Professional Education

Board Certification: American Board of Pediatrics, Pediatric Nephrology (2020)
Medical Education: University of Saskatchewan College of Medicine (1981) Canada
Fellowship: Dalhousie University Residency Training (1988) Canada
Residency: Winnipeg Children's Hospital (1986) Canada
Residency: Dalhousie University (1985) Canada
Fellowship: UCLA Health Sciences (1991) CA
Internship: University of Saskatchewan (1982) Canada
Fellowship, UCLA, Pediatric Transplant Immunology (1991)
Fellowship, Dalhousie University, Halifax, Pediatric Nephrology (1988)
Pediatric Residency, University of Manitoba, Pediatrics Yr III (1986)
Pediatric Residency, Dalhousie University, Halifax, Pediatrics I & II (1985)
Interneship, U. of Saskatchewan, Rotating Interne (1982)
MD with Distinction, University of Saskatchewan, Medicine (1981)

Contact

Academic pgrimm@stanford.edu Tel: (650) 723-7903 Fax: (650) 498-6714

Alternate Contact Kim Sands Admin. Pediatric Nephrology ksands@stanford.edu Tel: 650-723-7903

Clinical (Primary)

This is the primary clinic for this clinical provider. For additional clinical locations and information, please visit the link(s) listed below in the 'Additional Clinical Info' section.

Pediatric Nephrology Clinic 770 Welch Rd Ste 300 Palo Alto CA 94304 Tel: (650) 724-0353 Fax: (650) 721-6685

Additional Clinical Info

Stanford Medicine Children's Health

Current Research and Scholarly Interests

Computerized image analysis of kidney and liver biopsies to quantitate and diagnose subtle changes in tissue structure.
Renal Inflammation
Renal Allograft Rejection
Renal Fibrosis in;
-Primary Kidney Disease
-Transplant Kidney Disease
Liver fibrosis
Steatohepatitis

Clinical Trials

Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor Recruiting
More
This is a single center, non-randomized, non-controlled open-label phase 1b/2a trial of performing sequential αβdepleted-HSCT and KT in patients requiring KT to prevent kidney rejection post-KT, in the absence of any post-KT immunosuppression, to abrogate the need for lifelong immunosuppression, the risk of chronic rejection and, ultimately, the need for repeated transplantation.
Lead Sponsor
Stanford Investigators
View full details
The Effect of Exercise on Muscle Dysfunction in Cystinosis Recruiting
More
Classification of activity tolerance is of importance in chronic progressive myopathies, not only to better understand functional implications of the disease state itself, but also for purposes of exercise prescription for health maintenance. Maximal exercise testing has been considered as the gold standard of assessing maximal aerobic capacity, however testing in individuals with neuromuscular disease is often limited due to pain, activity intolerance, musculoskeletal impairments, fatigue and other such related variables. Often, submaximal exercise testing can overcome some of these obstacles, and as such, is used frequently in the clinical environment. Non-ambulatory exercise testing utilizing an arm ergometer specifically has not been studied as heavily, especially in those with progressive myopathies. For this study, we will use maximal aerobic capacity testing for individuals with Cystinosis Myopathy utilizing a bike ergometer to allow testing of individuals regardless of their ambulatory status.

Lead Sponsor
- Stanford University
Stanford Investigators
View full details
Pharmacokinetics, Safety and Tolerability of Single-dose Belatacept in Adolescent Kidney Transplant Recipients Not Recruiting
More
The purpose of this study is to evaluate how well adolescent kidney transplant patients tolerate a single dose of belatacept they receive at least 6 months after transplant surgery, and how their body handles the drug.

Stanford is currently not accepting patients for this trial. For more information, please contact Paul Grimm, Site 0006, 650-725-5295.
Lead Sponsor
Stanford Investigators
- Paul C. Grimm
View full details
Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant Not Recruiting
More
The aim of this study is to evaluate whether peri-transplant administration of a drug named aminophylline to children undergoing a kidney transplant from deceased donors improves early graft function and also projects on long term graft function.

Stanford is currently not accepting patients for this trial. For more information, please contact Vivian Shih, MD, 650-723-7903.

Lead Sponsor
- Stanford University
Stanford Investigators
- Paul C. Grimm
View full details

2023-24 Courses

Independent Studies
- Directed Reading in Pediatrics
  PEDS 299 (Aut, Win, Spr, Sum)
- Early Clinical Experience
  PEDS 280 (Aut, Win, Spr, Sum)
- Graduate Research
  PEDS 399 (Aut, Win, Spr, Sum)
- Medical Scholars Research
  PEDS 370 (Aut, Win, Spr, Sum)
- Undergraduate Directed Reading/Research
  PEDS 199 (Aut, Win, Spr, Sum)

Stanford Advisees

Postdoctoral Faculty Sponsor
Xavier Gaeta, Joseph Myrie, Jessica Ashley Williams

All Publications

Profiles With Related Publications

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Steven R. Alexander, MD

Professor of Pediatrics (Nephrology), Emeritus
Clinical Focus
Nephrology (Kidney), Pediatric, Pediatric Nephrology, Dialysis, Kidney Transplantation, Continuous Renal Replacement Therapies, Hypertension, Acute and Chronic Kidney Failure
Research Interests
Dialysis, kidney transplantation, continuous renal replacement therapy in pediatric patients; chronic kidney disease in pediatric patients.

145 Total Publications
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William Berquist

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Pediatric Gastroenterology, Ped Gastroenterology
Research Interests
Gastroenterology, gastointestinal motility, clinical management of pediatric liver transplant recipients.

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Gerald Berry

Richard Kempson, M.D., Professor of Surgical Pathology
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Pathology and Laboratory Medicine, Anatomic and Clinical Pathology
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Cardiopulmonary and pulmonary transplant medicine; diagnostic surgical pathology

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Stephan Busque

Professor of Surgery (Abdominal Transplantation)
Clinical Focus
General Surgery, Kidney and Pancreas Transplantation, Liver Transplantation
Research Interests
My research interest is focused on the improvement of clinical immunosuppression. I am involved in the evaluation of new immunosuppressive drugs, potentially more efficacious or less toxic. My ultimate goal is to achieve tolerance, a state that would obviate the need for any drugs. I am an investigator part of a multidisciplinary tolerance induction project using total lymphoid irradiation and donor hematopoietic stem cells infusion after living donor kidney transplantation.

116 Total Publications
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Abanti Chaudhuri

Clinical Professor, Pediatrics - Nephrology
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Pediatric Nephrology, Pediatric Hypertension, Pediatric kidney transplantation

54 Total Publications
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Sharon F. Chen

Clinical Professor, Pediatrics - Infectious Diseases
Clinical Focus
Pediatric Infectious Diseases, Immunocompromised Hosts
Research Interests
My research interest is in viral infections affecting immunocompromised patients. As Co-director of the Pediatric Infectious Diseases Program for Immunocompromised Hosts, I develop and conduct clinical and translational studies to establish best practices for these patients.
My education scholarship interests are in refining active learning to improve student learning, to characterize adaptive expertise of physicians, and to create a tool that assesses "thinking": Stanford CASE

16 Total Publications
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Kenneth L. Cox

Professor of Pediatrics (Gastroenterology) at the Lucile Salter Packard Children's Hospital, Emeritus
Research Interests
Gastroenterology, biliary motility, hormonal regulation, embryology, gastrointestinal tract, clinical management of pediatric liver transplant recipients.

68 Total Publications
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Carlos O. Esquivel, M.D., Ph.D.,FACS

Arnold and Barbara Silverman Professor in Pediatric Transplantation and Professor of Surgery (Abdominal Transplantation) and of Pediatrics (Gastroenterology, Hepatology and Nutrition)
Clinical Focus
Liver Transplantation, General Surgery, Intestinal Transplantation, Pediatric LiverTransplantation, Liver cancer
Research Interests
1) Induction of immunotolerance
2) Rejection of liver and intestinal transplantation.
3) Clinical outcomes of children with unresectable liver tumors.

450 Total Publications
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C. Garrison Fathman

Professor of Medicine (Immunology and Rheumatology), Emeritus
Research Interests
My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.

326 Total Publications
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Sharon Hunt, MD

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224 Total Publications
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Neeraja Kambham

Professor of Pathology
Clinical Focus
Renal Pathology, Medical Liver Pathology, Anatomic and Clinical Pathology
Research Interests
Dr. Kambham's research interests primarily involve medical diseases and transplantation pathology of the kidney and liver.

162 Total Publications
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Kiran Kaur Khush, MD

Professor of Medicine (Cardiovascular Medicine)
Clinical Focus
Cardiovascular Medicine, Heart Transplantation, Heart Failure, Mechanical circulatory support, Advanced Heart Failure and Transplant Cardiology
Research Interests
Dr. Khush's clinical research interests include the evaluation of donors and recipients for heart transplantation; mechanisms of adverse outcomes after heart transplantation, including cardiac allograft vasculopathy and antibody-mediated rejection; and development of non-invasive diagnostic approaches for post-transplant monitoring.

211 Total Publications