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Dr. Bollyky is an Immunologist and Infectious Disease specialist at Stanford Medical Center.
The Bollyky lab studies the innate immune response to injury and infection. Our goals are to gain insight into fundamental disease mechanisms and to generate novel therapies to improve human health. While we focus on basic mechanisms of pathogenesis, most of our work centers around two diseases - diabetes and cystic fibrosis (CF).<br/><br/>One area of active research involves bacteriophages – viruses that infect bacteria. The human body contains more bacteriophages than human cells but their impact on human biology is largely unknown. Current efforts are focused on understanding how bacteriophage interact with mammalian cells, how this infection influences local immunity, and how phage shape the immune response to commensal and pathogenic bacteria. We also have active efforts involved in characterizing the "phageome" - the collection of phages present in the body. <br/><br/>A second area of active research involves biofilms - the communities of polymers and bacteria that colonize infected tissues. The extracellular matrix present in biofilms exerts important but poorly understood effects on chronic infection. We are interested in how biofilms modulate human immunity, prevent diffusion of antibiotics, and contribute to chronic infection. <br/><br/>A third area of investigation is the tissue extracellular matrix at sites of injury and infection. In particular, we are interested in the roles that hyaluronan and other extracellular matrix polymers play in immune regulation. We use models of autoimmunity and infection to learn how the extracellular matrix and inflammation influences innate immunity and local immune regulation. <br/><br/><br/>Looking for a lab? <br/><br/>We are actively recruiting structural biologists, biochemists, immunologists, and microbiologists for post-doctoral positions in the lab. If interested, please contact Dr. Bollyky at email@example.com<br/><br/>For Stanford Undergraduates interested in joining the lab, we require a minimum commitment of a full year (including full-time work in the lab for at least one summer).<br/><br/>We take high school and undergraduate students through the SSRP program: https://biosciences.stanford.edu/prospective/diversity/ssrp/
A Study of Oral Hymecromone and Hyaluronan Synthesis
The purpose of this study is to add further understanding to the doses of hymecromone that
effectively and safely lead to the inhibition of hyaluronan synthesis. In this study we will
investigate both circulating hyaluronan in the serum, as well as tissue hyaluronan, using
sputum samples as a non-invasive surrogate.
This is a parallel, open-label, single-center, dose-response study of hymecromone in healthy
adults 18 years of age or older. Up to 18 participants will be enrolled. Participants will be
treated for 4 days with study drug. Safety as well as biomarkers of pharmacokinetic and
pharmacodynamic response will be monitored during therapy.
Stanford is currently not accepting patients for this trial.
For more information, please contact Adam Frymoyer, MD, .
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