Bachelor of Science, Massachusetts Institute of Technology (2007)
Doctor of Philosophy, Brown University (2015)
John Huguenard, Postdoctoral Faculty Sponsor
Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia and abnormal, hypersynchronous oscillations that manifest behaviorally as absence seizures. In this review, we highlight new findings that refine thalamic contributions to cortical rhythms and suggest that thalamic oscillators may be subject to both local and global control. We describe endogenous thalamic mechanisms that limit network synchrony and discuss how these protective brakes might be restored to prevent absence seizures. Finally, we describe how intrinsic and circuit-level specializations among thalamocortical loops may determine their involvement in widespread oscillations and render subsets of thalamic nuclei especially vulnerable to pathological synchrony.
View details for DOI 10.1016/j.neuron.2016.10.024
View details for Web of Science ID 000388572700007
View details for PubMedID 27883901
View details for PubMedCentralID PMC5131525