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Bio

Institute Affiliations

  • Member, Maternal & Child Health Research Institute (MCHRI)

Honors & Awards

  • Pre-doctoral Fellow, American Heart Association (2015-2017)
  • Graduate Student of Distinction, University of Nebraska Medical Center (2015)
  • Dean's Award for Academic Excellence, University of Dhaka (2013)

Professional Education

  • Doctor of Philosophy, University of Nebraska Medical Center (2018)
  • Master of Science, University Of Dhaka (2013)
  • Bachelor of Science, University Of Dhaka (2012)

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Contact

Research & Scholarship

Current Research and Scholarly Interests

Immunological pathophysiology of Pediatric Acute-onset Neuropsychiatric Syndrome

Lab Affiliations

Publications

All Publications

  • EHD4 is a novel regulator of urinary water homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology Rahman, S. S., Moffitt, A. E., Trease, A. J., Foster, K. W., Storck, M. D., Band, H., Boesen, E. I. 2017; 31 (12): 5217?33

    Abstract

    The Eps15-homology domain-containing (EHD) protein family comprises 4 members that regulate endocytic recycling. Although the kidney expresses all 4 EHD proteins, their physiologic roles are largely unknown. This study focused on EHD4, which we found to be expressed differentially across nephron segments with the highest expression in the inner medullary collecting duct. Under baseline conditions,Ehd4-/-[EHD4-knockout (KO)] mice on a C57Bl/6 background excreted a higher volume of more dilute urine than control C57Bl/6 wild-type (WT) mice while maintaining a similar plasma osmolality. Urine excretion after an acute intraperitoneal water load was significantly increased in EHD4-KO mice compared to WT mice, and although EHD4-KO mice concentrated their urine during 24-h water restriction, urinary osmolality remained significantly lower than in WT mice, suggesting that EHD4 plays a role in renal water handling. Total aquaporin 2 (AQP2) and phospho-S256-AQP2 (pAQP2) protein expression in the inner medulla was similar in the two groups in baseline conditions. However, localization of both AQP2 and pAQP2 in the renal inner medullary principal cells appeared more dispersed, and the intensity of apical membrane staining for AQP2 was reduced significantly (by ?20%) in EHD4-KO mice compared to WT mice in baseline conditions, suggesting an important role of EHD4 in trafficking of AQP2. Together, these data indicate that EHD4 play important roles in the regulation of water homeostasis.-Rahman, S. S., Moffitt, A. E. J., Trease, A. J., Foster, K. W., Storck, M. D., Band, H., Boesen, E. I. EHD4 is a novel regulator of urinary water homeostasis.

    View details for DOI 10.1096/fj.201601182RR

    View details for PubMedID 28778975

    View details for PubMedCentralID PMC5690383

  • Outside the mainstream: novel collecting duct proteins regulating water balance AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Rahman, S. S., Boesen, E. I. 2016; 311 (6): F1341-F1345

    Abstract

    Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.

    View details for DOI 10.1152/ajprenal.00488.2016

    View details for Web of Science ID 000389647100028

    View details for PubMedID 27784697

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