Bio
Heike Elisabeth Daldrup-Link is a clinician-scientist in the Department of Radiology at Stanford University with subspecialisation in pediatric radiology, pediatric oncology imaging, and molecular imaging. Dr. Daldrup-Link trained at the University of Münster and the Technical University of Munich, Germany. She worked as an Assistant and Associate Professor at the University of California, San Francisco from 2003 to 2010, before joining Stanford Radiology in 2010. Her research interest focuses on the development of novel pediatric molecular imaging techniques, which interface observations of living cells with nanoparticle development and multimodality imaging technologies:
Dr. Daldrup-Link developed several novel concepts for pediatric oncology imaging, such as tumor characterization through the EPR effect (US6009342-A), MR imaging of tumor associated inflammation with iron oxide nanoparticles (Clin Ca Res 2011 and 2018), image-guided cancer therapy without side effects through tumor-enzyme activated theranostic nanoparticles (Small 2014 and Molecular Oncology 2019) and radiation-free whole body staging of children with cancer (Lancet Oncology 2014 and Radiology 2020). Dr. Daldrup-Link?s cellular imaging studies also yielded several new and patented ideas for in vivo imaging of stem cell transplants establishing immediately clinically applicable technologies for: in vivo stem cell tracking with FDA-approved nanoparticles (US14/161,315), in vivo imaging of stem cell rejection processes with immune-cell targeted tracers, and MRI-detection of stem cell apoptosis with enzyme-activatable contrast agents (ACS Nano 2015) and iron oxide nanoparticle-enhanced MRI (Radiology 2019 and Theranostics 2020). Over the past 10 years, Dr. Daldrup-Link's team has received 77 honors and awards for innovative cellular imaging research.
Clinical Focus
- Pediatric Radiology
- Pediatric Oncology Imaging
- Diagnostic Radiology
Academic Appointments
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Professor, Radiology - Pediatric Radiology
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Professor (By courtesy), Pediatrics - Hematology & Oncology
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Member, Bio-X
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Member, Stanford Cancer Institute
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Member, Wu Tsai Neurosciences Institute
Administrative Appointments
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Associate Chair for Diversity, Department of Radiology, Stanford School of Medicine (2017 - Present)
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Co-Director, Cancer Imaging & Early Detection Program, Stanford Cancer Institute (2017 - Present)
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Director, Pediatric Molecular Imaging, Molecular Imaging Program at Stanford (2017 - Present)
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Chair, Communications and Publications Committee, World Molecular Imaging Society (WMIS) (2015 - 2019)
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Co-Chair (with S. Voss, Boston Childrens Hospital), ACR Committee on Pediatric Imaging Research, American College of Radiology (2013 - 2017)
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Chair, Imaging and Radiotherapeutics Committee, American Association for Cancer Research Annual Meeting (2010 - 2010)
Honors & Awards
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Excellence in Diversity and Inclusion Award, Stanford Biosciences (2020)
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Cover Article, July 2019 issue of Nanomedicine & Nanobiotechnology (2019)
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Cover Article, October 2019 issue of Molecular Oncology (2019)
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Cover Article, July 2019 issue of Radiology (2019)
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Elected Member, International Skeletal Society (2019)
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Harry Fischer Lifetime Achievement Award for Contrast Media Research, Contrast Media Research Conference, CMR, World Molecular Imaging Society, WMIS (2019)
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Cover Article, September 2018 issue of Clinical Cancer Research (2018)
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Member, AIMBE College of Fellows, American Institute for Medical and Biological Engineering (AIMBE) (2018)
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John F. Caffey Lecture, The Children?s Hospital of Philadelphia (CHOP), PA (2017)
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RSNA Bronze Visionary Donor Award (T. Link and H. Daldrup-Link), RSNA Research & Education Foundation (2017)
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'Ken Fellows Lecture', The Children?s Hospital of Philadelphia (CHOP), PA (2016)
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Member, American Society for Clinical Investigation (ASCI) (2015)
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Jorge Barrio Plenary Lecture for Advances in Clinical Research on Stem Cell Imaging, World Molecular Imaging Congress (2014)
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Research featured on the cover of the March issue, Small (2014)
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Harvey White Memorial Lecture, Ann & Robert H. Lurie Children?s Hospital, Northwestern University Feinberg School of Medicine, Chicago (2013)
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Berdon Award for the best basic science paper, published in Pediatric Radiology in 2011, Society for Pediatric Radiology (2012)
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Distinguished Investigator Award, Academy of Radiology Research (2012)
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R.O.S.E. Award (Recognition of Service Excellence), Lucile Packard Children's Hospital, Stanford University (2012)
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Author of the 10th and 17th most cited articles (out of 1,100 articles), Journal of Visualized Experiments (2011)
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Distinguished Reviewer, Journal of Magnetic Resonance Imaging, International Society for Magnetic Resonance in Medicine (2011)
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Editor's recognition award with special distinction for reviews for the journal Radiology, Radiology Editorial Board (2011)
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Research featured on the cover of the September issue, Clinical Cancer Research (2011)
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Editor's recognition award with special distinction for reviews for the journal Radiology, Radiology Editorial Board (2010)
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Berdon Award for the best basic science paper, published in Pediatric Radiology in 2008, Society for Pediatric Radiology (2009)
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Caffey Award for Basic Sciences, Society for Pediatric Radiology (2007)
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New Investigators Award, American Association of University Radiologists (AUR) (2006)
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Innovation in Science Award for Research on Targeted MR Contrast Agents, University of California in San Francisco (UCSF) (2005)
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Roentgen Award for research on "New Molecular Imaging Techniques for Bone Marrow Imaging", Roentgen Society (2005)
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Stipend for International Young Academics, Radiological Society of North America (RSNA) (2002)
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Coolidge Award for Research on Macromolecular MR Contrast Agents, Roentgen Society, Award sponsored by GE Medical Systems (2000)
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Caffey Award for Basic Sciences, Society for Pediatric Radiology (1997)
Boards, Advisory Committees, Professional Organizations
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Diversity & Inclusion Committee, Society for Pediatric Radiology (2020 - Present)
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Member, Nominations Committee for WMIS president and board members, World Molecular Imaging Society (2020 - Present)
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Ad hoc reviewer, ZCA1 SRB-K Study Section: Clinical & Translational Research, NCI (2019 - Present)
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Oncology Imaging Committee, Society for Pediatric Radiology (2019 - Present)
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Member, Editorial Board, Journal of Nuclear Medicine (2018 - Present)
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Member, RSNA Margulis Award Nominating Committee, Radiological Society of North America (2018 - Present)
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Reviewer and special emphasis panel member, Loan Repayment Program, National Cancer Institute (2018 - Present)
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Member, Education Committee, Annual Meeting of the American Association for Cancer Research (2018 - 2019)
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Member, Imaging Subcommittee and Review Committee, Fellow Nominations, American Institute for Medical and Biomedical Engineering (2018 - 2019)
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Member, Editorial Board, Nanotheranostics (2017 - Present)
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Member, Program Committee, Contrast Media Research Conference (CMR 2017), WMIS: http://contrastmediaresearch.org (2017 - Present)
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Global Council Member, World Molecular Imaging Society, European Society for MI and Federation of Asian Societies for MI (2017 - 2019)
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Member, Leadership Committee, Women In Molecular Imaging Network (WIMIN), World Molecular Imaging Society (WMIS) (2016 - Present)
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Member, Pediatric Radiology Committee, Radiological Society of North America (RSNA) (2015 - Present)
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Co-Chair and Organizer (together with Eric Ahrens, UCSD), ISMRM Cell Tracking Workshop, La Jolla, CA (2015 - 2015)
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International Advisory Board, The Lancet Hematology (2014 - Present)
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Member, Board of Trustees, World Molecular Imaging Society (2014 - 2018)
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Member, American College of Radiology Commission on Pediatric Imaging (2013 - 2017)
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Member, Bylaws Committee, Society for Pediatric Radiology (SPR) (2012 - 2013)
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Associate Editor for ?Contrast Media?, Radiology (2011 - 2018)
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Member, Education Exhibits Committee, Annual Meeting of the Radiological Society of North America (RSNA) (2011 - 2018)
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Deputy Editor, Academic Radiology (2010 - Present)
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Member, Molecular Imaging Committee, Annual Meeting of the Radiological Society of North America (RSNA) (2010 - 2012)
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Editorial Board Member, Pediatric Radiology (2007 - 2015)
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Member, scientific program committee, Association of University Radiologists (AUR) (2007 - 2015)
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Member, Children?s Oncology Group (2004 - Present)
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Editorial Board Member, European Radiology (2003 - 2012)
Professional Education
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CAQ, American Board of Radiology, Continued added qualification in Pediatric Radiology (2019)
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Board Certification: American Board of Radiology, Diagnostic Radiology (2015)
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Fellowship: UCSF Diagnostic Radiology Residency (1997) CA
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Fellowship: Schwabing Children's Hospital Kinderklinkik Schwabing (2003) Germany
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Radiology Board Certification, Bavarian Medical Association (Bayerische Landesärztekammer; BLÄK), Radiology (2001)
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Residency: Technical University of Munich (2001) Germany
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Residency: University of Munster Medical School (2000) Germany
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Internship: University of Munster Medical School (1995) Germany
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Medical Education: University of Munster Medical School (1993) Germany
Community and International Work
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Member, Greenpeace
Ongoing Project
No
Opportunities for Student Involvement
No
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Member of the American College of Radiology (ACR) Foundation International Outreach Committee
Populations Served
worldwide
Ongoing Project
Yes
Opportunities for Student Involvement
Yes
Patents
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Heike Daldrup-Link. "United States Patent WO/2018/217943 Anti-Warburg Nanoparticles", Leland Stanford Junior University, Apr 16, 2020
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Hossein Nejadnik, Olga Lenkov, Heike Daldrup-Link. "United States Patent 14/210,752 Compositions and methods for mesenchymal and/or chondrogenic differentiation of stem cells", Stanford University, Mar 14, 2014
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Robert Falconer, Paul Loadman (Bradford), Jason Gill (Durham); Jianghong Rao; Heike Daldrup-Link (Stanford). "United States Patent 13-005 Activatable theranostic nanoparticles", Bradford University, UK and Stanford University, USA, Aug 15, 2013
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Heike Daldrup-Link. "United States Patent 13/923962 Immunotherapy for cancer treatment using iron oxide nanoparticles", Stanford University, Jun 21, 2013
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Heike Daldrup-Link. "United States Patent 61/755283 In vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation", Stanford University, Jan 22, 2013
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Heike Daldrup-Link, David Shames, Robert Brasch. "United States Patent US6009342-A Imaging method for determining the pathologic grade of a tumor in situ, useful for determining malignancy or non-malignancy", University of California San Francisco, Feb 27, 1998